Asish K Ghosh
Affiliation: Northwestern University
Ghosh A, Quaggin S, Vaughan D. Molecular basis of organ fibrosis: potential therapeutic approaches. Exp Biol Med (Maywood). 2013;238:461-81 pubmed publisher
..The significance of endothelial to mesenchymal transition (EndMT) and senescence, two newly emerged fields in fibrosis research, has also been discussed...
Ghosh A, Nagpal V, Covington J, Michaels M, Vaughan D. Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): differential expression of microRNAs during EndMT. Cell Signal. 2012;24:1031-6 pubmed publisher
..Pharmacologic agents that restrict the progression of cardiac EndMT, a phenomenon that is found in adults only in the pathological conditions, in targeting specific miRNA may be helpful in preventing and treating cardiac fibrosis. ..
Ghosh A, Murphy S, Kishore R, Vaughan D. Global gene expression profiling in PAI-1 knockout murine heart and kidney: molecular basis of cardiac-selective fibrosis. PLoS ONE. 2013;8:e63825 pubmed publisher
..The significance of these observations in the light of heart-specific profibrotic signaling and fibrogenesis are discussed. ..
Ghosh A, Varga J. The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis. J Cell Physiol. 2007;213:663-71 pubmed
Ghosh A, Wei J, Wu M, Varga J. Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gamma. Biochem Biophys Res Commun. 2008;374:231-6 pubmed publisher
Ghosh A, Bhattacharyya S, Wei J, Kim S, Barak Y, Mori Y, et al
. Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator. FASEB J. 2009;23:2968-77 pubmed publisher
..Pharmacological activation of PPAR-gamma thus may represent a novel therapeutic approach to target p300-dependent TGF-beta profibrotic responses such as stimulation of collagen gene expression. ..
Ghosh A, Bradham W, Gleaves L, De Taeye B, Murphy S, Covington J, et al
. Genetic deficiency of plasminogen activator inhibitor-1 promotes cardiac fibrosis in aged mice: involvement of constitutive transforming growth factor-beta signaling and endothelial-to-mesenchymal transition. Circulation. 2010;122:1200-9 pubmed publisher