William C Reinhold
Affiliation: National Institutes of Health
- Reinhold W, Varma S, Sunshine M, Rajapakse V, Luna A, Kohn K, et al. The NCI-60 Methylome and Its Integration into CellMiner. Cancer Res. 2017;77:601-612 pubmed publisher..Overall, our database provides a resource of pharmacologic data that can reinforce known therapeutic strategies and identify novel drugs and drug targets across multiple cancer types. Cancer Res; 77(3); 601-12. ©2016 AACR. ..
- Reinhold W, Erliandri I, Liu H, Zoppoli G, Pommier Y, Larionov V. Identification of a predominant co-regulation among kinetochore genes, prospective regulatory elements, and association with genomic instability. PLoS ONE. 2011;6:e25991 pubmed publisher..We propose that the comparison of expression profiles in the NCI-60 cell line panel could be a tool for the identification of other gene groups whose products are involved in the assembly of organelle protein complexes. ..
- Reinhold W, Reimers M, Lorenzi P, Ho J, Shankavaram U, Ziegler M, et al. Multifactorial regulation of E-cadherin expression: an integrative study. Mol Cancer Ther. 2010;9:1-16 pubmed publisher..Finally, levels of cellular E-cad expression are associated with levels of cell-cell adhesion and response to drug treatment. ..
- Reinhold W, Mergny J, Liu H, Ryan M, Pfister T, Kinders R, et al. Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron. Cancer Res. 2010;70:2191-203 pubmed publisher..The observations reported here suggest the hypothesis that there is a conserved negative transcription regulator within intron 1 of the TOP1 gene associated with a quadruplex-prone region. ..