Thomas H Bugge

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. Bugge T, Antalis T, Wu Q. Type II transmembrane serine proteases. J Biol Chem. 2009;284:23177-81 pubmed publisher
    ..Progress has also been made in identifying molecular substrates and endogenous inhibitors. This minireview summarizes the current knowledge of the rapidly advancing TTSP field. ..
  2. Madsen D, Jürgensen H, Siersbæk M, Kuczek D, Grey Cloud L, Liu S, et al. Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake. Cell Rep. 2017;21:3662-3671 pubmed publisher
    ..This study identifies a function of TAMs in altering the tumor microenvironment through endocytic collagen turnover and establishes macrophages as centrally engaged in tumor-associated collagen degradation. ..
  3. Peters D, Szabo R, Friis S, Shylo N, Uzzun Sales K, Holmbeck K, et al. The membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity. J Biol Chem. 2014;289:14740-9 pubmed publisher
    ..This study provides the first demonstration that essential in vivo functions of prostasin are executed by a non-enzymatic activity of this unique membrane-anchored serine protease. ..
  4. Friis S, Sales K, Schafer J, Vogel L, Kataoka H, Bugge T. The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin. J Biol Chem. 2014;289:22319-32 pubmed publisher
    ..Taken together, these data indicate that HAI-1 regulates the activity of activated matriptase, whereas HAI-2 has an essential role in regulating prostasin-dependent matriptase zymogen activation. ..
  5. Friis S, Madsen D, Bugge T. Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin. J Biol Chem. 2016;291:2577-82 pubmed publisher
    ....
  6. Szabo R, Lantsman T, Peters D, Bugge T. Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin. Development. 2016;143:2818-28 pubmed publisher
    ....
  7. Friis S, Tadeo D, Le Gall S, Jürgensen H, Sales K, Camerer E, et al. Matriptase zymogen supports epithelial development, homeostasis and regeneration. BMC Biol. 2017;15:46 pubmed publisher
    ..The study demonstrates that the matriptase zymogen is biologically active and is capable of executing developmental and homeostatic functions of the protease. ..

Detail Information

Publications7

  1. Bugge T, Antalis T, Wu Q. Type II transmembrane serine proteases. J Biol Chem. 2009;284:23177-81 pubmed publisher
    ..Progress has also been made in identifying molecular substrates and endogenous inhibitors. This minireview summarizes the current knowledge of the rapidly advancing TTSP field. ..
  2. Madsen D, Jürgensen H, Siersbæk M, Kuczek D, Grey Cloud L, Liu S, et al. Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake. Cell Rep. 2017;21:3662-3671 pubmed publisher
    ..This study identifies a function of TAMs in altering the tumor microenvironment through endocytic collagen turnover and establishes macrophages as centrally engaged in tumor-associated collagen degradation. ..
  3. Peters D, Szabo R, Friis S, Shylo N, Uzzun Sales K, Holmbeck K, et al. The membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity. J Biol Chem. 2014;289:14740-9 pubmed publisher
    ..This study provides the first demonstration that essential in vivo functions of prostasin are executed by a non-enzymatic activity of this unique membrane-anchored serine protease. ..
  4. Friis S, Sales K, Schafer J, Vogel L, Kataoka H, Bugge T. The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin. J Biol Chem. 2014;289:22319-32 pubmed publisher
    ..Taken together, these data indicate that HAI-1 regulates the activity of activated matriptase, whereas HAI-2 has an essential role in regulating prostasin-dependent matriptase zymogen activation. ..
  5. Friis S, Madsen D, Bugge T. Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin. J Biol Chem. 2016;291:2577-82 pubmed publisher
    ....
  6. Szabo R, Lantsman T, Peters D, Bugge T. Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin. Development. 2016;143:2818-28 pubmed publisher
    ....
  7. Friis S, Tadeo D, Le Gall S, Jürgensen H, Sales K, Camerer E, et al. Matriptase zymogen supports epithelial development, homeostasis and regeneration. BMC Biol. 2017;15:46 pubmed publisher
    ..The study demonstrates that the matriptase zymogen is biologically active and is capable of executing developmental and homeostatic functions of the protease. ..