Thomas H Bugge
Affiliation: National Institutes of Health
- Bugge T, Antalis T, Wu Q. Type II transmembrane serine proteases. J Biol Chem. 2009;284:23177-81 pubmed publisher..Progress has also been made in identifying molecular substrates and endogenous inhibitors. This minireview summarizes the current knowledge of the rapidly advancing TTSP field. ..
- Madsen D, JÃ¼rgensen H, SiersbÃ¦k M, Kuczek D, Grey Cloud L, Liu S, et al. Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake. Cell Rep. 2017;21:3662-3671 pubmed publisher..This study identifies a function of TAMs in altering the tumor microenvironment through endocytic collagen turnover and establishes macrophages as centrally engaged in tumor-associated collagen degradation. ..
- Peters D, Szabo R, Friis S, Shylo N, Uzzun Sales K, Holmbeck K, et al. The membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity. J Biol Chem. 2014;289:14740-9 pubmed publisher..This study provides the first demonstration that essential in vivo functions of prostasin are executed by a non-enzymatic activity of this unique membrane-anchored serine protease. ..
- Friis S, Sales K, Schafer J, Vogel L, Kataoka H, Bugge T. The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin. J Biol Chem. 2014;289:22319-32 pubmed publisher..Taken together, these data indicate that HAI-1 regulates the activity of activated matriptase, whereas HAI-2 has an essential role in regulating prostasin-dependent matriptase zymogen activation. ..
- Friis S, Madsen D, Bugge T. Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin. J Biol Chem. 2016;291:2577-82 pubmed publisher....
- Szabo R, Lantsman T, Peters D, Bugge T. Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin. Development. 2016;143:2818-28 pubmed publisher....
- Friis S, Tadeo D, Le Gall S, Jürgensen H, Sales K, Camerer E, et al. Matriptase zymogen supports epithelial development, homeostasis and regeneration. BMC Biol. 2017;15:46 pubmed publisher..The study demonstrates that the matriptase zymogen is biologically active and is capable of executing developmental and homeostatic functions of the protease. ..