Affiliation: Mount Sinai School of Medicine
Choi S, Wang Q, Jia J, Pincas H, Turgeon J, Sealfon S. Growth differentiation factor 9 (GDF9) forms an incoherent feed-forward loop modulating follicle-stimulating hormone ?-subunit (FSH?) gene expression. J Biol Chem. 2014;289:16164-75 pubmed publisher
..These results identify GDF9 as contributing to an incoherent feed-forward loop, comprising both intracellular and secreted components, that regulates FSH? expression in response to activation of cell surface GnRH receptors. ..
Gorenshteyn D, Zaslavsky E, Fribourg M, Park C, Wong A, Tadych A, et al
. Interactive Big Data Resource to Elucidate Human Immune Pathways and Diseases. Immunity. 2015;43:605-14 pubmed publisher
..ImmuNet should be widely beneficial for investigating the mechanisms of the human immune system and immunological diseases. ..
Choi S, Wang Q, Jia J, Chikina M, Pincas H, Dolios G, et al
. Characterization of Gonadotrope Secretoproteome Identifies Neurosecretory Protein VGF-derived Peptide Suppression of Follicle-stimulating Hormone Gene Expression. J Biol Chem. 2016;291:21322-21334 pubmed
..Our results support the concept that signaling specificity from the cell membrane GnRH receptor to the nuclear Fshb gene involves integration of intracellular signaling and exosignaling regulatory motifs. ..
Patil S, Fribourg M, Ge Y, Batish M, Tyagi S, Hayot F, et al
. Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-Î² response to viral infection. Sci Signal. 2015;8:ra16 pubmed publisher
..Integration of simulations and experiments identified the role of paracrine signaling in increasing the number of cells that express Ifnb1 over time and in calibrating the immune response to viral infection. ..
SugÃ¡r I, Das J, Jayaprakash C, Sealfon S. Multiscale Modeling of Complex Formation and CD80 Depletion during Immune Synapse Development. Biophys J. 2017;112:997-1009 pubmed publisher
..Our results are consistent with the CTLA4 transendocytosis hypothesis and suggest the importance of lateral diffusion of surface proteins in contributing to a gradual increase in Signal 1 and Signal 2. ..
Vodovotz Y, Xia A, Read E, Bassaganya Riera J, Hafler D, Sontag E, et al
. Solving Immunology?. Trends Immunol. 2017;38:116-127 pubmed publisher
Thakar J, Hartmann B, Marjanovic N, Sealfon S, Kleinstein S. Comparative analysis of anti-viral transcriptomics reveals novel effects of influenza immune antagonism. BMC Immunol. 2015;16:46 pubmed publisher
..Application of BETA to genome-wide transcriptional profiling data from human DCs identified SATB1 as a novel effect of influenza antagonism. ..
Stern E, Ruf Zamojski F, Zalepa King L, Pincas H, Choi S, Peskin C, et al
. Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency. J Biol Chem. 2017;292:9815-9829 pubmed publisher
..These results provide a foundation for understanding the role of multiple regulatory factors in modulating Fshb gene activity. ..
Hartmann B, Albrecht R, Zaslavsky E, Nudelman G, Pincas H, Marjanovic N, et al
. Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death. Nat Commun. 2017;8:1931 pubmed publisher
..Using recombinant viruses, we identify the HA genomic segment as the mediator of cell death inhibition. These results show how pandemic influenza viruses subvert the immune response. ..