Christine B Kern
Affiliation: Medical University of South Carolina
- Kern C, Norris R, Thompson R, Argraves W, Fairey S, Reyes L, et al. Versican proteolysis mediates myocardial regression during outflow tract development. Dev Dyn. 2007;236:671-83 pubmed..Taken together, we conclude that intact versican and G1-containing versican cleavage products have opposing effects on myocardial cells and that versican proteolysis may facilitate the loss of distal myocardium during OFT remodeling. ..
- Kern C, Wessels A, McGarity J, Dixon L, Alston E, Argraves W, et al. Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies. Matrix Biol. 2010;29:304-16 pubmed publisher..In addition, these studies identify ADAMTS9 as a potential candidate gene for congenital cardiac anomalies. Mouse models of ADAMTS9 deficiency may be useful to study myxomatous valve degeneration. ..
- Dupuis L, Berger M, FELDMAN S, Doucette L, Fowlkes V, Chakravarti S, et al. Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly. J Mol Cell Cardiol. 2015;84:70-80 pubmed publisher..Further investigation into the role of LUM may yield novel therapeutic targets and/or biomarkers for patients with cardiovascular disease. ..
- Dupuis L, Doucette L, Rice A, Lancaster A, Berger M, Chakravarti S, et al. Development of myotendinous-like junctions that anchor cardiac valves requires fibromodulin and lumican. Dev Dyn. 2016;245:1029-42 pubmed publisher..Moreover, FMOD and LUM may facilitate mesenchymal cell differentiation in late stages of cardiac valve development. Developmental Dynamics 245:1029-1042, 2016. © 2016 Wiley Periodicals, Inc. ..