John S Torday


Affiliation: Los Angeles Biomedical Research Institute
Country: USA


  1. request reprint
    Torday J, Rehan V. Developmental cell/molecular biologic approach to the etiology and treatment of bronchopulmonary dysplasia. Pediatr Res. 2007;62:2-7 pubmed
    ..It is critically important to judiciously select physiologically and developmentally relevant interventions when treating the preterm neonate. ..
  2. Torday J. A central theory of biology. Med Hypotheses. 2015;85:49-57 pubmed publisher
    ..The proposed approach is scale-free and predictive, offering a Central Theory of Biology. ..
  3. Torday J. Pleiotropy as the Mechanism for Evolving Novelty: Same Signal, Different Result. Biology (Basel). 2015;4:443-59 pubmed publisher
    ..The power of this perspective is exemplified by the resolution of evolutionary gradualism and punctuated equilibrium in much the same way that Niels Bohr resolved the paradoxical duality of light as Complementarity. ..
  4. Torday J. Homeostasis as the Mechanism of Evolution. Biology (Basel). 2015;4:573-90 pubmed publisher
  5. Torday J, Ihida Stansbury K, Rehan V. Leptin stimulates Xenopus lung development: evolution in a dish. Evol Dev. 2009;11:219-24 pubmed publisher
    ..This model provides a cipher for understanding the evolution of complex physiology. ..
  6. Torday J, Rehan V. On the evolution of the pulmonary alveolar lipofibroblast. Exp Cell Res. 2016;340:215-9 pubmed publisher
    ..Moreover, such detailed knowledge of the workings of the lipofibroblast have provided insight to the etiology and effective treatment of Bronchopulmonary Dysplasia based on physiologic principles rather than on pharmacology. ..
  7. Torday J, Miller W. Biologic relativity: Who is the observer and what is observed?. Prog Biophys Mol Biol. 2016;121:29-34 pubmed publisher
    ..Furthermore, the entire cell including its cytoskeletal apparatus and membranes that participate in the resolution of biological uncertainties must be considered as having equivalent primacy with genomes in evolutionary terms. ..
  8. Torday J, Miller W. The Unicellular State as a Point Source in a Quantum Biological System. Biology (Basel). 2016;5: pubmed publisher
    ..This requisite biological conjunction can now be properly assessed as the focal point of reconciliation between biology and quantum phenomena, illustrated by deconvoluting complex physiologic traits back to their unicellular origins. ..
  9. Torday J. The Emergence of Physiology and Form: Natural Selection Revisited. Biology (Basel). 2016;5: pubmed publisher

More Information


  1. Torday J, Miller W. Phenotype as Agent for Epigenetic Inheritance. Biology (Basel). 2016;5: pubmed publisher
    ..Furthermore, as first principles of physiology determine the limits of epigenetic inheritance, a coherent justification can thereby be provided for the obligate return of all multicellular eukaryotes to the unicellular state. ..
  2. request reprint
    Torday J, Rehan V. Up-regulation of fetal rat lung parathyroid hormone-related protein gene regulatory network down-regulates the Sonic Hedgehog/Wnt/betacatenin gene regulatory network. Pediatr Res. 2006;60:382-8 pubmed
    ..This is the first evidence that alveolar fluid distension is an organizing principle for PTHrP signaling down-regulation of the Shh/Wnt/betacatenin pathway. ..
  3. Torday J, Powell F, Farmer C, Orgeig S, Nielsen H, Hall A. Leptin integrates vertebrate evolution: from oxygen to the blood-gas barrier. Respir Physiol Neurobiol. 2010;173 Suppl:S37-42 pubmed publisher
  4. TORDAY J, Rehan V. A cell-molecular approach predicts vertebrate evolution. Mol Biol Evol. 2011;28:2973-81 pubmed publisher
    ..As a result, it predicts how cell-molecular changes in this process can cause disease and offers counterintuitive insights to diagnosis and treatment based on evolutionary principles. ..
  5. Torday J, Rehan V. Neutral lipid trafficking regulates alveolar type II cell surfactant phospholipid and surfactant protein expression. Exp Lung Res. 2011;37:376-86 pubmed publisher
    ..The authors propose, therefore, that ADRP is the physiologic determinant for the elusive coordinated, stoichiometric synthesis of surfactant phospholipid and protein by pulmonary ATII cells. ..
  6. Torday J, Miller W. The resolution of ambiguity as the basis for life: A cellular bridge between Western reductionism and Eastern holism. Prog Biophys Mol Biol. 2017;131:288-297 pubmed publisher
    ..Viewing the life circumstance in this manner permits a reasoned unification between Western rational reductionism and Eastern holism. ..
  7. Tozzi A, Peters J, Chafin C, De Falco D, Torday J. A timeless biology. Prog Biophys Mol Biol. 2018;134:38-43 pubmed publisher
    ..We discuss the implications in biology: when assessing living beings, the underrated role of isolated "spatial" modifications needs to be emphasized, living apart the evolutionary role of time. ..