- Flow cytometry-based biosensor for detection of multivalent proteinsX Song
Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87544, USA
Anal Biochem 284:35-41. 2000..The surface density and the ratio of donor/acceptor-labeled GM1 on the surfaces of phospholipid bilayers are optimized to achieve high sensitivity...
- Detection of multivalent interactions through two-tiered energy transferX Song
Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Anal Biochem 291:133-41. 2001..One of the most significant improvements of the scheme over one-stage FRET is a dramatic decrease in the background fluorescence of the acceptor fluorescence, which, theoretically and practically, increases the detection sensitivity...
- Direct, ultrasensitive, and selective optical detection of protein toxins using multivalent interactionsX Song
Chemical Science and Technology Division, Los Alamos National Laboratory, New Mexico 87545, USA
Anal Chem 71:2097-107. 1999..This approach can easily be adapted to any biosensor scheme that relies on multiple receptors or co-receptors. The methods can also be applied to investigate the kinetics and thermodynamics of the multivalent interactions...