Hamamura K, Lin C, Yokota H. Salubrinal reduces expression and activity of MMP13 in chondrocytes. Osteoarthritis Cartilage. 2013;21:764-72 pubmed publisher
..The results demonstrate that salubrinal downregulates expression and activity MMP13 through p38 and NF?B signaling, suggesting its potential usage to treat degenerative diseases such as osteoarthritis. ..
Hamamura K, Chen A, Tanjung N, Takigawa S, Sudo A, Yokota H. In vitro and in silico analysis of an inhibitory mechanism of osteoclastogenesis by salubrinal and guanabenz. Cell Signal. 2015;27:353-62 pubmed publisher
..Collectively, a systems-biology approach allows the prediction of a RANKL-salubrinal/guanabenz-NFATc1 regulatory axis, and in vitro assays validate an involvement of AP-1 transcription factors in suppression of osteoclastogenesis. ..