John J Guinan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Progress in cochlear physiology after Békésy
    John J Guinan
    Eaton Peabody Laboratories, Dept of Otolaryngology, Mass Eye and Ear Infirmary, Boston, MA 02114, USA
    Hear Res 293:12-20. 2012
  2. pmc How are inner hair cells stimulated? Evidence for multiple mechanical drives
    John J Guinan
    Eaton Peabody Laboratory of Auditory Physiology, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Hear Res 292:35-50. 2012
  3. pmc Cochlear efferent innervation and function
    John J Guinan
    Eaton Peabody Laboratories, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Curr Opin Otolaryngol Head Neck Surg 18:447-53. 2010
  4. pmc Medial olivocochlear efferent inhibition of basilar-membrane responses to clicks: evidence for two modes of cochlear mechanical excitation
    John J Guinan
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, Massachusetts 02114, USA
    J Acoust Soc Am 124:1080-92. 2008
  5. pmc Medial olivocochlear efferent reflex in humans: otoacoustic emission (OAE) measurement issues and the advantages of stimulus frequency OAEs
    John J Guinan
    Eaton Peabody Laboratory of Auditory Physiology, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 4:521-40. 2003
  6. ncbi request reprint Olivocochlear efferents: anatomy, physiology, function, and the measurement of efferent effects in humans
    John J Guinan
    Harvard Medical School, Boston, Massachusetts, USA
    Ear Hear 27:589-607. 2006
  7. pmc Medial-olivocochlear-efferent inhibition of the first peak of auditory-nerve responses: evidence for a new motion within the cochlea
    John J Guinan
    Eaton Peabody Laboratory of Auditory Physiology, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3002, USA
    J Acoust Soc Am 118:2421-33. 2005
  8. ncbi request reprint Time-course of the human medial olivocochlear reflex
    Bradford C Backus
    Eaton Peabody Laboratory of Auditory Physiology, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Acoust Soc Am 119:2889-904. 2006
  9. ncbi request reprint Central auditory pathways mediating the rat middle ear muscle reflexes
    Daniel J Lee
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:358-69. 2006
  10. pmc Medial olivocochlear reflex interneurons are located in the posteroventral cochlear nucleus: a kainic acid lesion study in guinea pigs
    Ronald K de Venecia
    Department of Otology and Laryngology, Harvard Medical School, and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Comp Neurol 487:345-60. 2005

Collaborators

Detail Information

Publications32

  1. pmc Progress in cochlear physiology after Békésy
    John J Guinan
    Eaton Peabody Laboratories, Dept of Otolaryngology, Mass Eye and Ear Infirmary, Boston, MA 02114, USA
    Hear Res 293:12-20. 2012
    ..Finally, we touch on cochlear pathologies including noise damage and aging, with an emphasis on where the field might go in the future...
  2. pmc How are inner hair cells stimulated? Evidence for multiple mechanical drives
    John J Guinan
    Eaton Peabody Laboratory of Auditory Physiology, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Hear Res 292:35-50. 2012
    ..The ability of these IHC drives to explain previously anomalous data provides strong, although indirect, evidence that these drives are significant and presents a new view of how the cochlea works at frequencies below 3 kHz...
  3. pmc Cochlear efferent innervation and function
    John J Guinan
    Eaton Peabody Laboratories, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Curr Opin Otolaryngol Head Neck Surg 18:447-53. 2010
    ..This review covers topics relevant to olivocochlear-efferent anatomy and function for which there are new findings in papers from 2009 to early 2010...
  4. pmc Medial olivocochlear efferent inhibition of basilar-membrane responses to clicks: evidence for two modes of cochlear mechanical excitation
    John J Guinan
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, Massachusetts 02114, USA
    J Acoust Soc Am 124:1080-92. 2008
    ....
  5. pmc Medial olivocochlear efferent reflex in humans: otoacoustic emission (OAE) measurement issues and the advantages of stimulus frequency OAEs
    John J Guinan
    Eaton Peabody Laboratory of Auditory Physiology, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 4:521-40. 2003
    ....
  6. ncbi request reprint Olivocochlear efferents: anatomy, physiology, function, and the measurement of efferent effects in humans
    John J Guinan
    Harvard Medical School, Boston, Massachusetts, USA
    Ear Hear 27:589-607. 2006
    ..Monitoring MOC effects in humans using OAEs should continue to provide valuable insights into the role of MOC efferents and may also provide clinical benefits...
  7. pmc Medial-olivocochlear-efferent inhibition of the first peak of auditory-nerve responses: evidence for a new motion within the cochlea
    John J Guinan
    Eaton Peabody Laboratory of Auditory Physiology, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3002, USA
    J Acoust Soc Am 118:2421-33. 2005
    ....
  8. ncbi request reprint Time-course of the human medial olivocochlear reflex
    Bradford C Backus
    Eaton Peabody Laboratory of Auditory Physiology, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Acoust Soc Am 119:2889-904. 2006
    ..Given the MOCR's time-course, it is best suited to operate on acoustic changes that persist for 100's of milliseconds...
  9. ncbi request reprint Central auditory pathways mediating the rat middle ear muscle reflexes
    Daniel J Lee
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:358-69. 2006
    ..Preliminary findings using surgical transection and focal lesioning of the auditory brainstem to interrupt the MEM reflexes suggest that MEM reflex interneurons are located in the ventral cochlear nucleus...
  10. pmc Medial olivocochlear reflex interneurons are located in the posteroventral cochlear nucleus: a kainic acid lesion study in guinea pigs
    Ronald K de Venecia
    Department of Otology and Laryngology, Harvard Medical School, and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Comp Neurol 487:345-60. 2005
    ..We suggest that multipolar cells within the PVCN have the distribution and response characteristics appropriate to be the MOC reflex interneurons...
  11. ncbi request reprint Vestibular evoked myogenic potentials versus vestibular test battery in patients with Meniere's disease
    Steven D Rauch
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston University Medical Center, Boston, Massachusetts 02114, USA
    Otol Neurotol 25:981-6. 2004
    ....
  12. pmc A new auditory threshold estimation technique for low frequencies: proof of concept
    Jeffery T Lichtenhan
    Massachusetts Eye and Ear Infirmary, Eaton Peabody Laboratory of Auditory Physiology, Boston, MA 02114, USA
    Ear Hear 34:42-51. 2013
    ..A long-term goal is to translate this technique for use in humans...
  13. pmc Measurement of the distribution of medial olivocochlear acoustic reflex strengths across normal-hearing individuals via otoacoustic emissions
    Bradford C Backus
    Speech and Hearing Bioscience and Technology, Harvard MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA
    J Assoc Res Otolaryngol 8:484-96. 2007
    ..g., enhancing signal detection in noise, reducing acoustic trauma), different people will have corresponding differences in their abilities to perform that function...
  14. ncbi request reprint Cochlear traveling-wave amplification, suppression, and beamforming probed using noninvasive calibration of intracochlear distortion sources
    Christopher A Shera
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, Massachusetts 02114, USA
    J Acoust Soc Am 121:1003-16. 2007
    ..Rather, the dominant factor governing the emission magnitude appears to be the variable directionality of the waves radiated by the distortion-source region, which acts as a distortion beamformer tuned by the primary frequency ratio...
  15. pmc Otoacoustic estimation of cochlear tuning: validation in the chinchilla
    Christopher A Shera
    Eaton Peabody Laboratories, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 11:343-65. 2010
    ..Finally, our estimates of human tuning suggest that the spatial spread of excitation of a pure tone along the human basilar membrane is comparable to that in other common laboratory animals...
  16. ncbi request reprint Stimulus-frequency-emission group delay: a test of coherent reflection filtering and a window on cochlear tuning
    Christopher A Shera
    Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary 243 Charles Street, Boston, Massachusetts 02114, USA
    J Acoust Soc Am 113:2762-72. 2003
    ..The measurements and analysis reported here illustrate the rich potential inherent in OAE measurements for obtaining valuable information about basic cochlear properties such as tuning...
  17. pmc On cochlear impedances and the miscomputation of power gain
    Christopher A Shera
    Eaton Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 12:671-6. 2011
    ..As a consequence of this error, Ren et al.'s measurements and analysis provide no evidence for power amplification in the cochlea. Compelling evidence for power amplification has, however, been previously provided by others...
  18. pmc Acoustic stimulation of human medial olivocochlear efferents reduces stimulus-frequency and click-evoked otoacoustic emission delays: Implications for cochlear filter bandwidths
    Nikolas A Francis
    Speech and Hearing Bioscience and Technology, Harvard MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA
    Hear Res 267:36-45. 2010
    ..5ms change in OAE delay at low frequencies, would have a profound effect on binaural localization if they were not balanced in the central nervous system, or by the MOC system producing similar changes in both ears...
  19. pmc Frequency tuning of medial-olivocochlear-efferent acoustic reflexes in humans as functions of probe frequency
    Watjana Lilaonitkul
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Neurophysiol 107:1598-611. 2012
    ..The implication of these results for MOC function, cochlear mechanics, and the production of SFOAEs are discussed...
  20. pmc Reflex control of the human inner ear: a half-octave offset in medial efferent feedback that is consistent with an efferent role in the control of masking
    Watjana Lilaonitkul
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Neurophysiol 101:1394-406. 2009
    ....
  21. ncbi request reprint Time-frequency analysis of auditory-nerve-fiber and basilar-membrane click responses reveal glide irregularities and non-characteristic-frequency skirts
    Tai Lin
    Eaton Peabody Laboratory of Auditory Physiology, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, Massachusetts 02114, USA
    J Acoust Soc Am 116:405-16. 2004
    ....
  22. doi request reprint Increasing the Stimulation Rate Reduces cVEMP Testing Time by More Than Half With No Significant Difference in Threshold
    Mark J van Tilburg
    Department of Otolaryngology Department of Otology and Laryngology, Harvard Medical School Department of Audiology Eaton Peabody Lab, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, U S A
    Otol Neurotol 37:933-6. 2016
    ..Assessing the effect of a higher stimulation rate in cervical vestibular evoked myogenic potential (cVEMP) outcome measurements...
  23. ncbi request reprint Serial cVEMP Testing is Sensitive to Disease Progression in Ménière Patients
    Mark J van Tilburg
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary Department of Otolaryngology, Harvard Medical School Department of Audiology Eaton Peabody Lab, Massachusetts Eye and Ear Infirmary, Massachusetts
    Otol Neurotol 37:1614-1619. 2016
    ..To assess the cervical vestibular evoked myogenic potentials (cVEMPs) ability to track disease progression in Ménière's disease patients over time and identify the most sensitive outcome measurement...
  24. doi request reprint Evaluating Inhibition of Motoneuron Firing From Electromyogram Data to Assess Vestibular Output Using Vestibular Evoked Myogenic Potentials
    S R Prakash
    1Harvard MIT Division of Health Science and Technology, Speech and Hearing Bioscience and Technology Program, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA 2Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA 3Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA 4Department of Audiology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA and 5Eaton Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Ear Hear 36:591-604. 2015
    ..The goal of this article was to compare how well VEMPid, VEMPpp, and nVEMPpp track inhibition depth...
  25. ncbi request reprint Vestibular evoked myogenic potentials in patients with superior semicircular canal dehiscence
    Rupprecht Milojcic
    Department of Otology and Laryngology, Harvard Medical School, 243 Charles St, Boston, MA 02114, USA
    Otol Neurotol 34:360-7. 2013
    ..To compare the audiometric and cervical vestibular evoked muscle potential (cVEMP) outcomes of ears with superior canal dehiscence (SSCD) to outcomes from normal ears and the unaffected ears of unilateral SSCD patients...
  26. ncbi request reprint Short-term sound temporal envelope characteristics determine multisecond time patterns of activity in human auditory cortex as shown by fMRI
    Michael P Harms
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    J Neurophysiol 93:210-22. 2005
    ..Thus fMRI waveshape may provide a window onto neural activity patterns that reflect the segmentation of our auditory environment into distinct, meaningful events...
  27. ncbi request reprint Allen-Fahey and related experiments support the predominance of cochlear slow-wave otoacoustic emissions
    Christopher A Shera
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, Massachusetts 02114, USA
    J Acoust Soc Am 121:1564-75. 2007
    ....
  28. doi request reprint Normalization reduces intersubject variability in cervical vestibular evoked myogenic potentials
    Mark J van Tilburg
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary Department of Otology and Laryngology, Harvard Medical School Department of Audiology, Massachusetts Eye and Ear Infirmary and Eaton Peabody Lab, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, U S A
    Otol Neurotol 35:e222-7. 2014
    ..In this study, we test the hypothesis that normalization of the raw cervical VEMP waveform causes a significant decrease in the intersubject variability...
  29. ncbi request reprint Vestibular evoked myogenic potentials show altered tuning in patients with Ménière's disease
    Steven D Rauch
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Otol Neurotol 25:333-8. 2004
    ..In this study, we test the hypothesis that the cochleosaccular hydrops of Ménière's syndrome leads to alterations in saccular motion that change the dynamics of the vestibular evoked myogenic potential...
  30. pmc Revised estimates of human cochlear tuning from otoacoustic and behavioral measurements
    Christopher A Shera
    Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 99:3318-23. 2002
    ..The sharper tuning may facilitate human speech communication...
  31. ncbi request reprint Vestibular evoked myogenic potential (VEMP) in patients with Ménière's disease with drop attacks
    Ferdinand C A Timmer
    Academic Medical Center, Amsterdam, The Netherlands
    Laryngoscope 116:776-9. 2006
    ....
  32. pmc Vestibular evoked myogenic potentials (VEMP) can detect asymptomatic saccular hydrops
    Ming Yee Lin
    Kaohsiung Veterans General Hospital, Haohsiung, Taiwan
    Laryngoscope 116:987-92. 2006
    ..The objective of this study was to explore the useful of vestibular evoked myogenic potential (VEMP) testing for detecting endolymphatic hydrops, especially in the second ear of patients with unilateral Ménière disease (MD)...