Bijli K, Kleinhenz J, Murphy T, Kang B, Adesina S, Sutliff R, et al
. Peroxisome proliferator-activated receptor gamma depletion stimulates Nox4 expression and human pulmonary artery smooth muscle cell proliferation. Free Radic Biol Med. 2015;80:111-20 pubmed publisher
..These results indicate that reductions in PPAR? caused by pathophysiological stimuli such as prolonged hypoxia exposure are sufficient to promote the proliferation of pulmonary vascular smooth muscle cells observed in PH pathobiology. ..
Blum J, Bijli K, Murphy T, Kleinhenz J, Hart C. Time-dependent PPARÎ³ Modulation of HIF-1Î± Signaling in Hypoxic Pulmonary Artery Smooth Muscle Cells. Am J Med Sci. 2016;352:71-9 pubmed publisher
..These findings provide novel evidence that PPARÎ³ modulates fundamental and acute cellular responses to hypoxia through both HIF-1-dependent and HIF-1-independent mechanisms. ..
Yeligar S, Kang B, Bijli K, Kleinhenz J, Murphy T, Torres G, et al
. PPAR? Regulates Mitochondrial Structure and Function and HPASMC Proliferation. Am J Respir Cell Mol Biol. 2017;: pubmed publisher
..Overexpression of PGC1? reversed hypoxia-induced HPASMC derangements. These findings provide additional mechanistic underpinnings for activating PPAR? as a novel therapeutic strategy in PH. ..