Jon G Wilkes

Summary

Affiliation: Food and Drug Administration
Country: USA

Publications

  1. ncbi request reprint Modeling and assaying dioxin-like biological effects for both dioxin-like and certain non-dioxin-like compounds
    Jon G Wilkes
    Division of Systems Toxicology, Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock 72205 7199, USA
    Toxicol Sci 102:187-95. 2008
  2. pmc Alignment-independent technique for 3D QSAR analysis
    Jon G Wilkes
    Division of Systems Biology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA
    J Comput Aided Mol Des 30:331-45. 2016
  3. doi request reprint Reduction of food matrix interference by a combination of sample preparation and multi-dimensional gating techniques to facilitate rapid, high sensitivity analysis for Escherichia coli serotype O157 by flow cytometry
    Jon G Wilkes
    National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Food Microbiol 30:281-8. 2012
  4. ncbi request reprint Improved cell typing by charge-state deconvolution of matrix-assisted laser desorption/ionization mass spectra
    Jon G Wilkes
    National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
    Rapid Commun Mass Spectrom 20:1595-603. 2006
  5. ncbi request reprint Pyrolysis mass spectrometry for distinguishing potential hoax materials from bioterror agents
    Jon G Wilkes
    Division of Systems Toxicology, National Center for Toxicological Research, USFDA, Jefferson, AR 72079, USA
    Rapid Commun Mass Spectrom 20:2383-6. 2006
  6. ncbi request reprint Rapid phenotypic characterization of Vibrio isolates by pyrolysis metastable atom bombardment mass spectrometry
    Jon G Wilkes
    Divisions of Systems Toxicology, Microbiology or Biochemical Toxicology, National Center for Toxicological Research, FDA, 3900 NCTR Drive, Jefferson, AR 72079, USA
    Antonie Van Leeuwenhoek 88:151-61. 2005
  7. ncbi request reprint Comparative structural connectivity spectra analysis (CoSCoSA) models of steroid binding to the corticosteroid binding globulin
    Richard D Beger
    Division of Chemistry, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
    J Chem Inf Comput Sci 42:1123-31. 2002
  8. ncbi request reprint Combining NMR spectral and structural data to form models of polychlorinated dibenzodioxins, dibenzofurans, and biphenyls binding to the AhR
    Richard D Beger
    Division of Chemistry, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
    J Comput Aided Mol Des 16:727-40. 2002
  9. ncbi request reprint Predicting toxic equivalence factors from 13C nuclear magnetic resonance spectra for dioxins, furans, and polychlorinated biphenyls using linear and nonlinear pattern recognition methods
    Dan A Buzatu
    Division of Chemistry, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Environ Toxicol Chem 23:24-31. 2004
  10. doi request reprint ¹³C NMR-distance matrix descriptors: optimal abstract 3D space granularity for predicting estrogen binding
    Svetoslav H Slavov
    Division of Systems Biology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Rd, Jefferson, Arkansas 72079, United States
    J Chem Inf Model 52:1854-64. 2012

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Modeling and assaying dioxin-like biological effects for both dioxin-like and certain non-dioxin-like compounds
    Jon G Wilkes
    Division of Systems Toxicology, Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock 72205 7199, USA
    Toxicol Sci 102:187-95. 2008
    ..It suggested that in silico and in vitro nomination protocols may facilitate practical risk assessment when chemical family members exhibit different degrees of toxicity operating via a common mechanism...
  2. pmc Alignment-independent technique for 3D QSAR analysis
    Jon G Wilkes
    Division of Systems Biology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA
    J Comput Aided Mol Des 30:331-45. 2016
    ....
  3. doi request reprint Reduction of food matrix interference by a combination of sample preparation and multi-dimensional gating techniques to facilitate rapid, high sensitivity analysis for Escherichia coli serotype O157 by flow cytometry
    Jon G Wilkes
    National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079, USA
    Food Microbiol 30:281-8. 2012
    ..3. The results suggested potential uses for regulatory screening and food industry process control...
  4. ncbi request reprint Improved cell typing by charge-state deconvolution of matrix-assisted laser desorption/ionization mass spectra
    Jon G Wilkes
    National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR 72079, USA
    Rapid Commun Mass Spectrom 20:1595-603. 2006
    ..Deconvolution may enhance detection of early disease state or therapy progress markers in various tissues analyzed by MALDI-MS...
  5. ncbi request reprint Pyrolysis mass spectrometry for distinguishing potential hoax materials from bioterror agents
    Jon G Wilkes
    Division of Systems Toxicology, National Center for Toxicological Research, USFDA, Jefferson, AR 72079, USA
    Rapid Commun Mass Spectrom 20:2383-6. 2006
    ..from nonbiological agents and that it can be a rapid method for detection of bacteria. MS data acquisition took only 7 min for each sample...
  6. ncbi request reprint Rapid phenotypic characterization of Vibrio isolates by pyrolysis metastable atom bombardment mass spectrometry
    Jon G Wilkes
    Divisions of Systems Toxicology, Microbiology or Biochemical Toxicology, National Center for Toxicological Research, FDA, 3900 NCTR Drive, Jefferson, AR 72079, USA
    Antonie Van Leeuwenhoek 88:151-61. 2005
    ..This integrated analytical, pattern-recognition system should be examined further for potential utility in clinical and public health diagnostic contexts...
  7. ncbi request reprint Comparative structural connectivity spectra analysis (CoSCoSA) models of steroid binding to the corticosteroid binding globulin
    Richard D Beger
    Division of Chemistry, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
    J Chem Inf Comput Sci 42:1123-31. 2002
    ....
  8. ncbi request reprint Combining NMR spectral and structural data to form models of polychlorinated dibenzodioxins, dibenzofurans, and biphenyls binding to the AhR
    Richard D Beger
    Division of Chemistry, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
    J Comput Aided Mol Des 16:727-40. 2002
    ..80. Another CoSCoSA model for all 52 compounds had an r2 of 0.85 and an average q(2)2 of 0.52. Major benefits of CoSCoSA modeling include ease of development since the technique does not use molecular docking routines...
  9. ncbi request reprint Predicting toxic equivalence factors from 13C nuclear magnetic resonance spectra for dioxins, furans, and polychlorinated biphenyls using linear and nonlinear pattern recognition methods
    Dan A Buzatu
    Division of Chemistry, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Environ Toxicol Chem 23:24-31. 2004
    ..The QSDAR models provide a rapid, simple way to model the toxicity of dioxin and dioxin-like compounds...
  10. doi request reprint ¹³C NMR-distance matrix descriptors: optimal abstract 3D space granularity for predicting estrogen binding
    Svetoslav H Slavov
    Division of Systems Biology, National Center for Toxicological Research, U S Food and Drug Administration, 3900 NCTR Rd, Jefferson, Arkansas 72079, United States
    J Chem Inf Model 52:1854-64. 2012
    ..13 ppm) and the precision of the calculated interatomic distances. The highest ranked bins from partial least-squares weights were found to be associated with structural features known to be essential for binding to the estrogen receptor...
  11. pmc Development of a Flow Cytometry-Based Method for Rapid Detection of Escherichia coli and Shigella Spp. Using an Oligonucleotide Probe
    Yong Xue
    Division of Systems Biology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR, United States of America
    PLoS ONE 11:e0150038. 2016
    ..coli cells in the presence of large numbers of other bacteria. This method can be used for rapid, economical, and stable detection of E. coli and Shigella contamination in the food industry and other contexts. ..
  12. ncbi request reprint Rapid phenotypic characterization of Salmonella enterica strains by pyrolysis metastable atom bombardment mass spectrometry with multivariate statistical and artificial neural network pattern recognition
    Jon G Wilkes
    National Center for Toxicological Research, FDA, 3900 NCTR Drive, Jefferson, AR 72079, USA
    J Microbiol Methods 61:321-34. 2005
    ..They each cross-validated by LOO at 90%. This is the first direct correlation of pyrolysis metastable atom bombardment mass spectrometry with immunological (e.g. serology) or molecular biology (e.g. PFGE) based techniques...
  13. doi request reprint Flow-Cytometry-Based Method to Detect Escherichia coli and Shigella Spp. Using 16S rRNA-Based Probe
    Yong Xue
    Division of Systems Biology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas
    Curr Protoc Toxicol 71:2.25.1-2.25.8. 2017
    ..coli in the presence of large numbers of other bacteria. Clear step-by-step protocols for cell concentration determination, sample preparation, and flow cytometric analysis are provided. © 2017 by John Wiley & Sons, Inc...
  14. doi request reprint Thymol treatment of bacteria prior to matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis aids in identifying certain bacteria at the subspecies level
    Ricky D Holland
    Division of Systems Biology Innovative Safety and Technologies Branch, USFDA National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA
    Rapid Commun Mass Spectrom 28:2617-26. 2014
    ..This results in poor reproducibility in identifying bacterial types and between laboratories. The need for a more broadly applicable and useful sample handling procedure is warranted...
  15. doi request reprint Photobleaching with phloxine B sensitizer to reduce food matrix interference for detection of Escherichia coli serotype O157:H7 in fresh spinach by flow cytometry
    Dan A Buzatu
    U S Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Food Microbiol 36:416-25. 2013
    ..The RAPID-B method limit of detection (LOD) was one cell in 25 g. It proved superior to the reference method (which incorporated real time-PCR, selective enrichment, and culture plating elements) in accuracy and speed...
  16. doi request reprint 3D-SDAR modeling of hERG potassium channel affinity: A case study in model design and toxicophore identification
    Iva B Stoyanova-Slavova
    Division of Systems Biology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA Electronic address
    J Mol Graph Model 72:246-255. 2017
    ..A U test along the distance axis of the most frequently occurring 3D-SDAR bins was used to set the distance limits of the toxicophore. This toxicophore was found to be similar to an earlier reported phospholipidosis (PLD) toxicophore...
  17. pmc Complementary PLS and KNN algorithms for improved 3D-QSDAR consensus modeling of AhR binding
    Svetoslav H Slavov
    Division of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    J Cheminform 5:47. 2013
    ....
  18. doi request reprint Partial least square and k-nearest neighbor algorithms for improved 3D quantitative spectral data-activity relationship consensus modeling of acute toxicity
    Iva B Stoyanova-Slavova
    Division of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arizona
    Environ Toxicol Chem 33:1271-82. 2014
    ..The presence of a second aromatic ring with highly electronegative substituents 5 Å to 7 Å apart from the first ring would lead to a further increase in toxicity...
  19. doi request reprint Level 2 validation of a flow cytometric method for detection of Escherichia coli O157:H7 in raw spinach
    Anna J Williams
    U S Food and Drug Administration, National Center for Toxicological Research, Division of Systems Biology, Jefferson, AR 72079, USA Electronic address
    Int J Food Microbiol 215:1-6. 2015
    ..In this validation study, the flow cytometry method was equal to the BAM in sensitivity and far superior in speed. ..
  20. pmc Instrumental improvements and sample preparations that enable reproducible, reliable acquisition of mass spectra from whole bacterial cells
    Pierre Alusta
    Innovative Safety Technologies Branch, Systems Biology Div, National Center for Toxicological Research, Food Drug Administration, Jefferson, AR, USA
    Rapid Commun Mass Spectrom 29:1961-8. 2015
    ..Rapid sub-species characterization of pathogens is required for timely responses in outbreak situations. Pyrolysis mass spectrometry (PyMS) has the potential to be used for this purpose...
  21. doi request reprint Computational identification of a phospholipidosis toxicophore using (13)C and (15)N NMR-distance based fingerprints
    Svetoslav H Slavov
    Division of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA
    Bioorg Med Chem 22:6706-14. 2014
    ....
  22. doi request reprint Improving proton MR spectroscopy of brain tissue for noninvasive diagnostics
    Pierre Alusta
    Division of Systems Biology, National Center for Toxicological Research, US FDA, Jefferson, Arkansas 72079, USA
    J Magn Reson Imaging 32:818-29. 2010
    ..To examine preprocessing methods affecting the potential use of Magnetic Resonance Spectroscopy (MRS) as a noninvasive modality for detection and characterization of brain lesions and for directing therapy progress...
  23. ncbi request reprint The use of carbon thirteen nuclear magnetic resonance spectra to predict dioxin and furan binding affinities to the aryl hydrocarbon receptor
    Lindsay Shade
    Division of Chemistry, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Environ Toxicol Chem 22:501-9. 2003
    ..The SDAR models provide a rapid, simple, and valid way to model the PCDF and PCDD binding activity in relation to the AhR...
  24. ncbi request reprint Defining and using microbial spectral databases
    Jon G Wilkes
    National Center for Toxicological Research, USFDA, Jefferson, Arkansas 72079, USA
    J Am Soc Mass Spectrom 13:875-87. 2002
    ..This type of data treatment is applicable for rapid detection in biowarfare and bioterror events as well as in forensic, research, and clinical laboratory contexts...
  25. pmc An integrated flow cytometry-based system for real-time, high sensitivity bacterial detection and identification
    Dan A Buzatu
    National Center for Toxicological Research, Food and Drug Administration FDA, Jefferson, Arkansas, United States of America
    PLoS ONE 9:e94254. 2014
    ..This system offers a powerful approach to real-time assessment of food safety, useful for industry self-monitoring and regulatory inspection. ..
  26. ncbi request reprint Comparative structural connectivity spectra analysis (CoSCoSA) models of steroids binding to the aromatase enzyme
    Richard D Beger
    Division of Chemistry, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
    J Mol Recognit 15:154-62. 2002
    ....