- Ware S, Harutyunyan K, Belmont J. Zic3 is critical for early embryonic patterning during gastrulation. Dev Dyn. 2006;235:776-85 pubmed..At later stages, deficiency of Zic3 results in abnormal mesoderm allocation. These results indicate a requirement for Zic3 during early embryogenesis prior to cardiac and visceral organ patterning. ..