Affiliation: Cincinnati Children's Hospital Medical Center
Kumar S, Wang J, Thomson A, Gandhi C. Hepatic stellate cells increase the immunosuppressive function of natural Foxp3+ regulatory T cells via IDO-induced AhR activation. J Leukoc Biol. 2017;101:429-438 pubmed publisher
..nTregs expanded by cryopreserved HSCs may have potential for clinical use. ..
Kumar S, Wang J, Shanmukhappa S, Gandhi C. Toll-Like Receptor 4-Independent Carbon Tetrachloride-Induced Fibrosis and Lipopolysaccharide-Induced Acute Liver Injury in Mice: Role of Hepatic Stellate Cells. Am J Pathol. 2017;187:1356-1367 pubmed publisher
..The results further indicate that LPS signaling in activated HSCs might be a mechanism of limiting liver fibrosis. ..
Rani R, Tandon A, Wang J, Kumar S, Gandhi C. Stellate Cells Orchestrate Concanavalin A-Induced Acute Liver Damage. Am J Pathol. 2017;187:2008-2019 pubmed publisher
..HSCs play an essential role in ConA-induced liver injury directly via the interferon-Î²/IRF1 axis, and by modulating properties of NPCs. ..