Nicole F Steinmetz
Affiliation: Case Western Reserve University
Le D, Lee K, Shukla S, Commandeur U, Steinmetz N. Potato virus X, a filamentous plant viral nanoparticle for doxorubicin delivery in cancer therapy. Nanoscale. 2017;9:2348-2357 pubmed publisher
..Our results open the door for further development of PVX and other high aspect ratio plant VNPs for applications in cancer therapy. ..
Wen A, Steinmetz N. Design of virus-based nanomaterials for medicine, biotechnology, and energy. Chem Soc Rev. 2016;45:4074-126 pubmed publisher
..We anticipate that this field will continue to evolve and grow, with exciting new possibilities stemming from advancements in the rational design of virus-based nanomaterials. ..
Uhde Holzem K, McBurney M, Tiu B, Advincula R, Fischer R, Commandeur U, et al
. Production of Immunoabsorbent Nanoparticles by Displaying Single-Domain Protein A on Potato Virus X. Macromol Biosci. 2016;16:231-41 pubmed publisher
..The new biomaterials presented could find applications as diagnostic tools for biomedical or environmental monitoring. ..
Bruckman M, Czapar A, Vanmeter A, Randolph L, Steinmetz N. Tobacco mosaic virus-based protein nanoparticles and nanorods for chemotherapy delivery targeting breast cancer. J Control Release. 2016;231:103-13 pubmed publisher
..Finally, we developed TMV and SNP formulations loaded with the chemotherapeutic doxorubicin, and we demonstrate the application of TMV rods and spheres for chemotherapy delivery targeting breast cancer. ..
Bruckman M, Randolph L, Vanmeter A, Hern S, Shoffstall A, Taurog R, et al
. Biodistribution, pharmacokinetics, and blood compatibility of native and PEGylated tobacco mosaic virus nano-rods and -spheres in mice. Virology. 2014;449:163-73 pubmed publisher
..Further, blood biocompatibility was supported, as none of the formulations induced clotting or hemolysis. This work lays the foundation for further application and tailoring of TMV for biomedical applications. ..
Pitek A, Jameson S, Veliz F, Shukla S, Steinmetz N. Serum albumin 'camouflage' of plant virus based nanoparticles prevents their antibody recognition and enhances pharmacokinetics. Biomaterials. 2016;89:89-97 pubmed publisher
..Therefore, SA-coatings may provide an alternative and improved coating technique to yield (plant virus-based) NPs with improved inÂ vivo properties enhancing drug delivery and molecular imaging. ..
Shukla S, Myers J, Woods S, Gong X, Czapar A, Commandeur U, et al
. Plant viral nanoparticles-based HER2 vaccine: Immune response influenced by differential transport, localization and cellular interactions of particulate carriers. Biomaterials. 2017;121:15-27 pubmed publisher
Gulati N, Pitek A, Steinmetz N, Stewart P. Cryo-electron tomography investigation of serum albumin-camouflaged tobacco mosaic virus nanoparticles. Nanoscale. 2017;9:3408-3415 pubmed publisher
Czapar A, Steinmetz N. Plant viruses and bacteriophages for drug delivery in medicine and biotechnology. Curr Opin Chem Biol. 2017;38:108-116 pubmed publisher
..Key target areas of development are their use in chemotherapy, photodynamic therapy, pesticide-delivery, gene therapy, vaccine carriers, and immunotherapy. ..