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Affiliation: Brown University
Lipscombe D, Pan J. Tripping the HCN breaker. Neuron. 2009;62:747-50 pubmed publisher
..In this issue of Neuron two manuscripts (Santoro et al. and Zolles et al.) report that HCN channel gating and expression are controlled by Trip8b (Pex5R) but with a bidirectional spin. ..
Jiang Y, Andrade A, Lipscombe D. Spinal morphine but not ziconotide or gabapentin analgesia is affected by alternative splicing of voltage-gated calcium channel CaV2.2 pre-mRNA. Mol Pain. 2013;9:67 pubmed publisher
..Our findings show that the analgesic action of morphine, but not ziconotide or gabapentin, to thermal stimuli is linked to which Cacna1b exon, e37a or e37b, is selected during alternative pre-mRNA splicing. ..
Lipscombe D, Andrade A. Calcium Channel CaVÎ±â‚ Splice Isoforms - Tissue Specificity and Drug Action. Curr Mol Pharmacol. 2015;8:22-31 pubmed