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Affiliation: Bristol-Myers Squibb
Das J, Moquin R, Dyckman A, Li T, Pitt S, Zhang R, et al. 5-amino-pyrazoles as potent and selective p38? inhibitors. Bioorg Med Chem Lett. 2010;20:6886-9 pubmed publisher
..Compound 2j was highly efficacious in vivo in inhibiting TNF? production in an acute murine model of TNF? production. X-ray co-crystallography of a 5-amino-pyrazole analog 2f bound to unphosphorylated p38? is also disclosed. ..