Darrell R Kapczynski


Affiliation: Agricultural Research Service
Country: USA


  1. Bertran K, Lee D, Criado M, Balzli C, Killmaster L, Kapczynski D, et al. Maternal antibody inhibition of recombinant Newcastle disease virus vectored vaccine in a primary or booster avian influenza vaccination program of broiler chickens. Vaccine. 2018;: pubmed publisher
    ..Our results demonstrate that MDA to AIV had minimal impact on the effectiveness of rHVT-H5, but MDA to AIV and/or NDV at the time of vaccination can prevent development of protective immunity from a primary or booster rNDV-H5 vaccine. ..
  2. Spackman E, Pantin Jackwood M, Swayne D, Suarez D, Kapczynski D. Impact of route of exposure and challenge dose on the pathogenesis of H7N9 low pathogenicity avian influenza virus in chickens. Virology. 2015;477:72-81 pubmed publisher
    ..Virus was shed at higher titers and spread to the kidneys in chickens inoculated by the intravenous route. Challenge experiments with three other human-origin H7N9 viruses showed a similar pattern of virus replication. ..
  3. Bertran K, Thomas C, Guo X, Bublot M, Pritchard N, Regan J, et al. Expression of H5 hemagglutinin vaccine antigen in common duckweed (Lemna minor) protects against H5N1 high pathogenicity avian influenza virus challenge in immunized chickens. Vaccine. 2015;33:3456-62 pubmed publisher
    ..Transgenic duckweed-derived HA could be a good alternative for producing high quality antigen for an injectable vaccine against H5N1 HPAI viruses. ..
  4. Costa Hurtado M, Afonso C, Miller P, Shepherd E, Cha R, Smith D, et al. Previous infection with virulent strains of Newcastle disease virus reduces highly pathogenic avian influenza virus replication, disease, and mortality in chickens. Vet Res. 2015;46:97 pubmed publisher
    ..The information obtained from these studies helps to understand the possible interactions and outcomes of infection (disease and virus shedding) when HPAIV and NDV co-infect chickens in the field. ..
  5. Kapczynski D, Esaki M, Dorsey K, Jiang H, Jackwood M, Moraes M, et al. Vaccine protection of chickens against antigenically diverse H5 highly pathogenic avian influenza isolates with a live HVT vector vaccine expressing the influenza hemagglutinin gene derived from a clade 2.2 avian influenza virus. Vaccine. 2015;33:1197-205 pubmed publisher
  6. request reprint
    Kapczynski D, Gonder E, Liljebjelke K, Lippert R, Petkov D, Tilley B. Vaccine-induced protection from egg production losses in commercial turkey breeder hens following experimental challenge with a triple-reassortant H3N2 avian influenza virus. Avian Dis. 2009;53:7-15 pubmed
    ..This study provides the first detailed description of the clinical protection afforded to laying turkey hens by vaccination against challenge with a circulating field isolate of a H3N2 triple-reassortant AIV. ..
  7. Kapczynski D, Swayne D. Influenza vaccines for avian species. Curr Top Microbiol Immunol. 2009;333:133-52 pubmed publisher
    ..In the current H5N1 HPAI epizootic, vaccines have been used in a variety of avian species as a part of an overall control program to aid in disease management and control. ..
  8. Kapczynski D, Pantin Jackwood M, Guzman S, Ricardez Y, Spackman E, Bertran K, et al. Characterization of the 2012 highly pathogenic avian influenza H7N3 virus isolated from poultry in an outbreak in Mexico: pathobiology and vaccine protection. J Virol. 2013;87:9086-96 pubmed publisher
    ..This study demonstrates the pathological consequences of the infection of chickens with the 2012 Mexican lineage H7N3 HPAI virus and provides support for effective programs of vaccination against this virus in poultry. ..
  9. Bertran K, Swayne D, Pantin Jackwood M, Kapczynski D, Spackman E, Suarez D. Lack of chicken adaptation of newly emergent Eurasian H5N8 and reassortant H5N2 high pathogenicity avian influenza viruses in the U.S. is consistent with restricted poultry outbreaks in the Pacific flyway during 2014-2015. Virology. 2016;494:190-7 pubmed publisher
    ..Although these initial U.S. H5 HPAI viruses had reduced adaptation and transmissibility in chickens, multi-generational passage in poultry could generate poultry adapted viruses with higher infectivity and transmissibility. ..

More Information


  1. DeJesus E, Costa Hurtado M, Smith D, Lee D, Spackman E, Kapczynski D, et al. Changes in adaptation of H5N2 highly pathogenic avian influenza H5 clade viruses in chickens and mallards. Virology. 2016;499:52-64 pubmed publisher
    ..Increased virus adaptation to chickens was observed with the poultry H5N2 viruses; however these viruses retained high adaptation to mallards but pathogenicity was differently affected. ..
  2. Kapczynski D, Pantin Jackwood M, Spackman E, Chrz─ůstek K, Suarez D, Swayne D. Homologous and heterologous antigenic matched vaccines containing different H5 hemagglutinins provide variable protection of chickens from the 2014 U.S. H5N8 and H5N2 clade highly pathogenic avian influenza viruses. Vaccine. 2017;35:6345-6353 pubmed publisher
    ..3.4.4 HPAI viruses. Updating the H5 hemagglutinin to be genetically closer to the outbreak virus and/or using a prime-boost strategy may be necessary for optimal protection. ..
  3. Bertran K, Balzli C, Lee D, Suarez D, Kapczynski D, Swayne D. Protection of White Leghorn chickens by U.S. emergency H5 vaccination against clade H5N2 high pathogenicity avian influenza virus. Vaccine. 2017;35:6336-6344 pubmed publisher
    ..These studies support the use of genetically related vaccines, possibly in combination with a broad protective priming vaccine, for emergency vaccination programs against clade H5Nx HPAI virus in young and adult layer chickens. ..
  4. Chrz─ůstek K, Lee D, Smith D, Sharma P, Suarez D, Pantin Jackwood M, et al. Use of Sequence-Independent, Single-Primer-Amplification (SISPA) for rapid detection, identification, and characterization of avian RNA viruses. Virology. 2017;509:159-166 pubmed publisher
    ..Taken together, these studies demonstrate a simple template enrichment protocol for rapid detection and accurate characterization of avian RNA viruses. ..