Graham S Taylor

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi request reprint Antigens and autophagy: the path less travelled?
    Graham S Taylor
    Cancer Research UK, Institute for Cancer Studies, University of Birmingham, Vincetn Drive, Birmingham, United Kingdom
    Autophagy 3:60-2. 2007
  2. doi request reprint Therapeutic vaccination strategies to treat nasopharyngeal carcinoma
    Graham S Taylor
    Cancer Immunology and Immunotherapy Centre, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK
    Chin Clin Oncol 5:23. 2016
  3. doi request reprint The immunology of Epstein-Barr virus-induced disease
    Graham S Taylor
    School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom email
    Annu Rev Immunol 33:787-821. 2015
  4. pmc Autophagy and immunity - insights from human herpesviruses
    Luke R Williams
    School of Cancer Sciences, University of Birmingham, Vincent Drive, Birmingham, UK
    Front Immunol 3:170. 2012
  5. pmc Autophagy in herpesvirus immune control and immune escape
    Graham S Taylor
    School of Cancer Sciences and Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, UK
    Herpesviridae 2:2. 2011
  6. pmc T cell detection of a B-cell tropic virus infection: newly-synthesised versus mature viral proteins as antigen sources for CD4 and CD8 epitope display
    Laura K Mackay
    School of Cancer Sciences and MRC Centre for Immune Regulation, College of Medicine, University of Birmingham, Birmingham, United Kingdom
    PLoS Pathog 5:e1000699. 2009
  7. doi request reprint CD4+ T-cell clones recognizing human lymphoma-associated antigens: generation by in vitro stimulation with autologous Epstein-Barr virus-transformed B cells
    Heather M Long
    Cancer Research UK Institute for Cancer Studies, School of Cancer Sciences, University of Birmingham, Vincent Drive, Birmingham, United Kingdom
    Blood 114:807-15. 2009
  8. pmc A novel latent membrane 2 transcript expressed in Epstein-Barr virus-positive NK- and T-cell lymphoproliferative disease encodes a target for cellular immunotherapy
    Christopher P Fox
    School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom
    Blood 116:3695-704. 2010
  9. ncbi request reprint A role for intercellular antigen transfer in the recognition of EBV-transformed B cell lines by EBV nuclear antigen-specific CD4+ T cells
    Graham S Taylor
    Cancer Research U K Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
    J Immunol 177:3746-56. 2006
  10. ncbi request reprint EBV latent membrane proteins (LMPs) 1 and 2 as immunotherapeutic targets: LMP-specific CD4+ cytotoxic T cell recognition of EBV-transformed B cell lines
    Tracey A Haigh
    Cancer Research United Kingdom Institute for Cancer Studies, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, United Kingdom
    J Immunol 180:1643-54. 2008

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Antigens and autophagy: the path less travelled?
    Graham S Taylor
    Cancer Research UK, Institute for Cancer Studies, University of Birmingham, Vincetn Drive, Birmingham, United Kingdom
    Autophagy 3:60-2. 2007
    ..It becomes important to know why, even in the same cell type, some antigens but not others appear to access the MHC class II presentation pathway by autophagy...
  2. doi request reprint Therapeutic vaccination strategies to treat nasopharyngeal carcinoma
    Graham S Taylor
    Cancer Immunology and Immunotherapy Centre, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK
    Chin Clin Oncol 5:23. 2016
    ..A safe therapeutic vaccine that was also able to be mass produced could, in principle, be used to vaccinate large numbers of patients after first line therapy to reduce recurrence. ..
  3. doi request reprint The immunology of Epstein-Barr virus-induced disease
    Graham S Taylor
    School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom email
    Annu Rev Immunol 33:787-821. 2015
    ..By contrast, a range of other EBV-positive malignancies of lymphoid or epithelial origin arise in individuals with seemingly intact immune systems through mechanisms that remain to be understood. ..
  4. pmc Autophagy and immunity - insights from human herpesviruses
    Luke R Williams
    School of Cancer Sciences, University of Birmingham, Vincent Drive, Birmingham, UK
    Front Immunol 3:170. 2012
    ..The ability of autophagy to degrade proteins located within the nucleus, the site of herpesvirus latency and replication, is also considered...
  5. pmc Autophagy in herpesvirus immune control and immune escape
    Graham S Taylor
    School of Cancer Sciences and Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, UK
    Herpesviridae 2:2. 2011
    ..These studies suggest that herpesviruses significantly modulate autophagy to escape from its functions in innate and adaptive immunity...
  6. pmc T cell detection of a B-cell tropic virus infection: newly-synthesised versus mature viral proteins as antigen sources for CD4 and CD8 epitope display
    Laura K Mackay
    School of Cancer Sciences and MRC Centre for Immune Regulation, College of Medicine, University of Birmingham, Birmingham, United Kingdom
    PLoS Pathog 5:e1000699. 2009
    ..Hence, newly-infected cells are rapidly visible only to the CD8 response; by contrast, latent infections, in which viral gene expression has been extinguished yet viral proteins persist, will remain visible to CD4+ T cells...
  7. doi request reprint CD4+ T-cell clones recognizing human lymphoma-associated antigens: generation by in vitro stimulation with autologous Epstein-Barr virus-transformed B cells
    Heather M Long
    Cancer Research UK Institute for Cancer Studies, School of Cancer Sciences, University of Birmingham, Vincent Drive, Birmingham, United Kingdom
    Blood 114:807-15. 2009
    ..Such antigens are therefore of potential value as targets for CD4(+) T cell-based immunotherapy...
  8. pmc A novel latent membrane 2 transcript expressed in Epstein-Barr virus-positive NK- and T-cell lymphoproliferative disease encodes a target for cellular immunotherapy
    Christopher P Fox
    School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom
    Blood 116:3695-704. 2010
    ..This study is registered at clinicaltrials.gov as NCT00062868...
  9. ncbi request reprint A role for intercellular antigen transfer in the recognition of EBV-transformed B cell lines by EBV nuclear antigen-specific CD4+ T cells
    Graham S Taylor
    Cancer Research U K Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
    J Immunol 177:3746-56. 2006
    ..w. antigenic species and required active Ag processing by recipient cells. We infer that intercellular Ag transfer plays a major role in the presentation of EBNA-derived CD4 epitopes by latently infected target cells...
  10. ncbi request reprint EBV latent membrane proteins (LMPs) 1 and 2 as immunotherapeutic targets: LMP-specific CD4+ cytotoxic T cell recognition of EBV-transformed B cell lines
    Tracey A Haigh
    Cancer Research United Kingdom Institute for Cancer Studies, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, United Kingdom
    J Immunol 180:1643-54. 2008
    ..We therefore infer that cytotoxic CD4+ T cells to a subset of LMP epitopes could have therapeutic potential against LMP-expressing tumors...
  11. pmc Nuclear location of an endogenously expressed antigen, EBNA1, restricts access to macroautophagy and the range of CD4 epitope display
    Carol S Leung
    School of Cancer Sciences and Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 107:2165-70. 2010
    ..We conclude that EBNA1's nuclear location limits its accessibility to the macroautophagy pathway and, in consequence, limits the level and range of EBNA1 CD4 epitopes naturally displayed on the infected cell surface...
  12. pmc Regression of Epstein-Barr virus-induced B-cell transformation in vitro involves virus-specific CD8+ T cells as the principal effectors and a novel CD4+ T-cell reactivity
    Nancy H Gudgeon
    CRUK Institute for Cancer Studies, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Virol 79:5477-88. 2005
    ..These novel effectors, whose antigen specificity remains to be determined, may also play a role in limiting virus-induced B-cell proliferation in vitro and in vivo...
  13. pmc Epstein-Barr virus evades CD4+ T cell responses in lytic cycle through BZLF1-mediated downregulation of CD74 and the cooperation of vBcl-2
    Jianmin Zuo
    Cancer Research UK Birmingham Cancer Centre, University of Birmingham, Birmingham, United Kingdom
    PLoS Pathog 7:e1002455. 2011
    ..We conclude that by inhibiting apoptosis, the vBcl-2 not only maintains cell viability to allow sufficient time for synthesis and accumulation of infectious virus progeny, but also enables BZLF1 to effect its immune evasion function...
  14. pmc Early T Cell Recognition of B Cells following Epstein-Barr Virus Infection: Identifying Potential Targets for Prophylactic Vaccination
    Jill M Brooks
    Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS Pathog 12:e1005549. 2016
    ..We infer that "first wave" antigens of the growth-transforming infection, especially EBNA2, constitute potential CD8+ T cell immunogens for inclusion in prophylactic EBV vaccine design. ..
  15. ncbi request reprint Cellular responses to viral infection in humans: lessons from Epstein-Barr virus
    Andrew D Hislop
    CRUK Institute for Cancer Studies and MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK B15 2TT
    Annu Rev Immunol 25:587-617. 2007
    ..This experiment of nature provides a system to advance understanding of immunological homeostasis in humans, illustrating how data obtained from the study of EBV have wider significance to the immunological community...
  16. doi request reprint The role of tetraspanin CD63 in antigen presentation via MHC class II
    Sven H Petersen
    School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Eur J Immunol 41:2556-61. 2011
    ..Taken together, our data reveal a new insight into the mechanisms by which tetraspanins are involved in the regulation of MHC II-dependent T-cell stimulation...
  17. doi request reprint Infectious agents in human cancers: lessons in immunity and immunomodulation from gammaherpesviruses EBV and KSHV
    Graham S Taylor
    CR UK Cancer Centre, School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, UK
    Cancer Lett 305:263-78. 2011
    ..Others develop in people that are not overtly immune suppressed and likely modulate the immunological response. This latter aspect of immune modulation by EBV and KSHV forms the basis of this review...
  18. doi request reprint Nuclear shelter: the influence of subcellular location on the processing of antigens by macroautophagy
    Carol S Leung
    School of Cancer Sciences and Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, UK
    Autophagy 6:560-1. 2010
    ..these observations raise the interesting question of how does EBV persist in the B cell system given the presence of strong CD4 T cell responses directed against the one protein the virus absolutely requires for long-term persistence?..
  19. pmc CD8 T cell recognition of endogenously expressed epstein-barr virus nuclear antigen 1
    Steven P Lee
    Institute for Cancer Studies, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK
    J Exp Med 199:1409-20. 2004
    ..We infer that EBNA1-specific CD8+ T cells do play a role in control of EBV infection in vivo and might be exploitable in the control of EBV+ malignancies...
  20. doi request reprint Immune defence against EBV and EBV-associated disease
    Heather M Long
    School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Curr Opin Immunol 23:258-64. 2011
    ....
  21. pmc Identification of cytomegalovirus-specific cytotoxic T lymphocytes in vitro is greatly enhanced by the use of recombinant virus lacking the US2 to US11 region or modified vaccinia virus Ankara expressing individual viral genes
    Naeem Khan
    CR UK Institute for Cancer Studies, Vincent Dr, Edgbaston, University of Birmingham, Birmingham B15 2TA, United Kingdom
    J Virol 79:2869-79. 2005
    ....
  22. doi request reprint T-Cell Responses to EBV
    Andrew D Hislop
    School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Curr Top Microbiol Immunol 391:325-53. 2015
    ..In this chapter, we will primarily review the role the αβ subset of T cells in the control of EBV in healthy and diseased individuals...
  23. pmc A recombinant modified vaccinia ankara vaccine encoding Epstein-Barr Virus (EBV) target antigens: a phase I trial in UK patients with EBV-positive cancer
    Graham S Taylor
    Cancer Research UK Centre, School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom
    Clin Cancer Res 20:5009-22. 2014
    ..A therapeutic vaccine comprising a recombinant vaccinia virus, MVA-EL, was designed to boost immunity to these tumor antigens. A phase I trial was conducted to demonstrate the safety and immunogenicity of MVA-EL across a range of doses...
  24. ncbi request reprint T cell-based therapies for EBV-associated malignancies
    Graham S Taylor
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Vincent Drive, Birmingham B15 2TT, UK
    Expert Opin Biol Ther 4:11-21. 2004
    ..Although it remains to be seen whether long-lasting sterilising immunity to EBV could be achieved, an alternative vaccine-based approach would be to develop a prophylactic vaccine to protect against primary EBV infection...
  25. ncbi request reprint CD4 and CD8 T cell responses to tumour-associated Epstein-Barr virus antigens in nasopharyngeal carcinoma patients
    Xiaorong Lin
    Sir Y K Pao Centre for Cancer, Hong Kong Cancer Institute, The Chinese University of Hong Kong, Hong Kong, China
    Cancer Immunol Immunother 57:963-75. 2008
    ....
  26. ncbi request reprint EBV-specific CD4+ T cell clones exhibit vigorous allogeneic responses
    Elise Landais
    Institut National de la Sante et de la Recherche Medicale, Unite 601, Institut de Biologie, Nantes, France
    J Immunol 177:1427-33. 2006
    ..As already proposed, the strong alloreactivity toward LCLs suggest that these cells could be used for selective depletion of alloreactive T cells...