Steven H Spoel
Affiliation: University of Edinburgh
Kneeshaw S, Spoel S. Thioredoxin-Dependent Decomposition of Protein S-Nitrosothiols. Methods Mol Biol. 2018;1747:281-297 pubmed publisher
..We show that this methodology identifies both global and specific protein-SNO targets of TRX in plant cell extracts. ..
Skelly M, Frungillo L, Spoel S. Transcriptional regulation by complex interplay between post-translational modifications. Curr Opin Plant Biol. 2016;33:126-132 pubmed publisher
..Complex interplay between these different post-translational modifications may provide robust control mechanisms to fine tune developmental and stress-responsive transcriptional programs. ..
Dussart F, Douglas R, SjÃ¶kvist E, Hoebe P, Spoel S, McGrann G. Genome-based discovery of polyketide-derived secondary metabolism pathways in the barley pathogen Ramularia collo-cygni. Mol Plant Microbe Interact. 2018;: pubmed publisher
Kneeshaw S, Gelineau S, Tada Y, Loake G, Spoel S. Selective protein denitrosylation activity of Thioredoxin-h5 modulates plant Immunity. Mol Cell. 2014;56:153-62 pubmed publisher
..Our data indicate that TRXh5 discriminates between protein-SNO substrates to provide previously unrecognized specificity and reversibility to protein-SNO signaling in plant immunity. ..
Kneeshaw S, Keyani R, Delorme Hinoux V, Imrie L, Loake G, Le Bihan T, et al
. Nucleoredoxin guards against oxidative stress by protecting antioxidant enzymes. Proc Natl Acad Sci U S A. 2017;: pubmed publisher
..These data suggest that unexpectedly H2O2-scavenging enzymes experience oxidative distress in ROS-rich environments and require reductive protection from NRX1 for optimal activity. ..
Frungillo L, Spoel S. Modulating the Modulator: Regulation of Protein Methylation by Nitric Oxide. Mol Cell. 2017;67:535-537 pubmed publisher
..Hu et al. (2017) demonstrate in this issue of Molecular Cell that S-nitrosylation selectively modulates enzymatic activity of a protein arginine methyltransferase vital to abiotic stress tolerance. ..