Davidson N, Fort M, Muller W, Leach M, Rennick D. Chronic colitis in IL-10-/- mice: insufficient counter regulation of a Th1 response. Int Rev Immunol. 2000;19:91-121 pubmed
..The findings of these mechanistic studies as they relate to our understanding of progressive inflammatory disease and the role of IL-10 in controlling the acute and chronic stages are discussed. ..
Vosshenrich C, Sharara L, Guy Grand D, Rajewsky K, Muller W, Di Santo J. Common cytokine receptor gamma chain (gammac)-deficient B cells persist in T cell-deficient gammac-mice and respond to a T-independent antigen. Eur J Immunol. 2000;30:1614-22 pubmed
..The gammac-/nude and gammac-/TCRbeta-/- mice provide new models to dissect the role of gammac-dependent receptors during murine B cell differentiation. ..
Muller W. Dissecting the cytokine network. Cell Immunol. 2006;244:162-4 pubmed
..This increase in complexity leads to fascinating challenges in the future. ..
Hancock J, Adams N, Aidinis V, Blake A, Bogue M, Brown S, et al
. Mouse Phenotype Database Integration Consortium: integration [corrected] of mouse phenome data resources. Mamm Genome. 2007;18:157-63 pubmed
..This process is ongoing and needs to be supported by the wider mouse genetics and phenotyping communities to succeed. We invite interested parties to contact us as we develop this process further. ..
Andratsch M, Mair N, Constantin C, Scherbakov N, Benetti C, Quarta S, et al
. A key role for gp130 expressed on peripheral sensory nerves in pathological pain. J Neurosci. 2009;29:13473-83 pubmed publisher
..Our results uncover the significance of gp130 expressed in peripheral pain sensing neurons in the pathophysiology of major clinical pain disorders and suggest their use as novel pain relieving agents in inflammatory and tumor pain. ..
Sayi A, Kohler E, Toller I, Flavell R, Muller W, Roers A, et al
. TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells. J Immunol. 2011;186:878-90 pubmed publisher
Schippers A, Kochut A, Pabst O, Frischmann U, Clahsen T, Tenbrock K, et al
. ?7 integrin controls immunogenic and tolerogenic mucosal B cell responses. Clin Immunol. 2012;144:87-97 pubmed publisher
..These observations suggest that ?7 integrin expression on cells of the innate immune system contributes to the critical role of ?7 integrin in the process of B cell tolerance. ..
Leal L, Moss D, Kuhn R, Muller W, Liew F. Interleukin-4 transgenic mice of resistant background are susceptible to Leishmania major infection. Eur J Immunol. 1993;23:566-9 pubmed
..These results, therefore, establish in a new animal model that IL-4 promotes disease development in murine cutaneous leishmaniasis. ..
Berg D, Davidson N, Kuhn R, Muller W, Menon S, Holland G, et al
. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest. 1996;98:1010-20 pubmed
..In 3-mo-old mutants, intestinal lesions were most severe in IL-10-/- 129/SvEv and IL-10-/- BALB/c strains, of intermediate severity in the IL-10-/- 129 x C57BL/6J outbreds, and least severe in the IL-10-/- C57BL/6J strain. ..
Schwenk F, Sauer B, Kukoc N, Hoess R, Muller W, Kocks C, et al
. Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains. J Immunol Methods. 1997;207:203-12 pubmed
..We demonstrate the usefulness of these antibodies by an analysis of Cre expression in mice carrying a cre-transgene under B cell-specific control. ..
Bungartz G, Stiller S, Bauer M, Muller W, Schippers A, Wagner N, et al
. Adult murine hematopoiesis can proceed without beta1 and beta7 integrins. Blood. 2006;108:1857-64 pubmed
..These data show that alpha4beta1 and alpha4beta7 are not required for blood cell differentiation, although in their absence alterations in numbers and distribution of progenitor cells were observed. ..
Luchtefeld M, Schunkert H, Stoll M, Selle T, Lorier R, Grote K, et al
. Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man. J Exp Med. 2007;204:1935-44 pubmed
..Thus, the acute phase reaction should be considered an important target for future drug development in the management of CAD. ..
Scholten J, Hartmann K, Gerbaulet A, Krieg T, Muller W, Testa G, et al
. Mast cell-specific Cre/loxP-mediated recombination in vivo. Transgenic Res. 2008;17:307-15 pubmed
..Our results show that the Mcpt5 promoter can drive Cre expression in a mast cell-specific fashion. We expect that our Mcpt5-Cre mice will be a useful tool for the investigation of mast cell biology. ..
Waibler Z, Anzaghe M, Konur A, Akira S, Muller W, Kalinke U. Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-alpha responses by pDC. Eur J Immunol. 2008;38:3127-37 pubmed publisher
..Analysis of purified DC subsets showed that conventional DC were the main IL-10 producers, whereas plasmacytoid DC hardly produced any IL-10. ..
Montoyo H, Vaccaro C, Hafner M, Ober R, Mueller W, Ward E. Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice. Proc Natl Acad Sci U S A. 2009;106:2788-93 pubmed publisher
..The primary sites for the maintenance of endogenous IgGs in mice are therefore endothelial and hematopoietic cells. ..
Fasnacht N, Greweling M, Bollati Fogolin M, Schippers A, Muller W. T-cell-specific deletion of gp130 renders the highly susceptible IL-10-deficient mouse resistant to intestinal nematode infection. Eur J Immunol. 2009;39:2173-83 pubmed publisher
..Taken together, the data demonstrate that gp130 signalling in T cells is a positive regulator of inflammatory processes, favouring the Th1/Th17 axis. ..
Loffert D, Ehlich A, Muller W, Rajewsky K. Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity. 1996;4:133-44 pubmed
..However, although mu chain double-producing B precursor cells are generated in lambda 5-deficient mice, such cells were not detected among surface immunoglobulin positive B cells. ..
Deckert M, Lütjen S, Leuker C, Kwok L, Strack A, Muller W, et al
. Mice with neonatally induced inactivation of the vascular cell adhesion molecule-1 fail to control the parasite in Toxoplasma encephalitis. Eur J Immunol. 2003;33:1418-28 pubmed
Morawetz R, Doherty T, Giese N, Hartley J, Muller W, Kuhn R, et al
. Resistance to murine acquired immunodeficiency syndrome (MAIDS). Science. 1994;265:264-6; author reply 267 pubmed
Croy B, Ashkar A, Foster R, DiSanto J, Magram J, Carson D, et al
. Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy. J Reprod Immunol. 1997;35:111-33 pubmed
Kuklin N, Rott L, Feng N, Conner M, Wagner N, Muller W, et al
. Protective intestinal anti-rotavirus B cell immunity is dependent on alpha 4 beta 7 integrin expression but does not require IgA antibody production. J Immunol. 2001;166:1894-902 pubmed
..Our findings suggest that alpha(4)beta(7) integrin expression is necessary for B cell-mediated immunity to RV independent of the presence of IgA. ..
Kellersmann R, Lazarovits A, Grant D, Garcia B, Chan B, Kellersmann A, et al
. Monoclonal antibody against beta7 integrins, but not beta7 deficiency, attenuates intestinal allograft rejection in mice. Transplantation. 2002;74:1327-34 pubmed
..The discrepancy in survival data obtained by mAb and beta7 deficiency may be a result of the more rapid activation of compensatory mechanisms in the knockout mice. ..
Ranson T, Vosshenrich C, Corcuff E, Richard O, Muller W, Di Santo J. IL-15 is an essential mediator of peripheral NK-cell homeostasis. Blood. 2003;101:4887-93 pubmed
..Finally, although NK cells bear functional inhibitory Ly49 receptors for MHC class I molecules, the presence or absence of specific ligands on host cells did not influence the survival or homeostatic expansion of donor NK cells. ..
Fingerle Rowson G, Petrenko O, Metz C, Forsthuber T, Mitchell R, Huss R, et al
. The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci U S A. 2003;100:9354-9 pubmed
..The data provide direct genetic evidence for a functional link between MIF and the p53 tumor suppressor and indicate an important and previously unappreciated role for MIF in carcinogenesis. ..
Fleige A, Alberti S, Gröbe L, Frischmann U, Geffers R, Muller W, et al
. Serum response factor contributes selectively to lymphocyte development. J Biol Chem. 2007;282:24320-8 pubmed
..We conclude that SRF fulfills essential and distinct functions in the differentiation of different types of lymphocytes. ..
Stehr M, Greweling M, Tischer S, Singh M, Blöcker H, Monner D, et al
. Charles River altered Schaedler flora (CRASF) remained stable for four years in a mouse colony housed in individually ventilated cages. Lab Anim. 2009;43:362-70 pubmed publisher
..CRASF remained stable for seven mouse generations and was efficiently transferred to the imported mouse strains. ..
Peters T, Bloch W, Pabst O, Wickenhauser C, Uthoff Hachenberg C, Schmidt S, et al
. Adaptive immune response to model antigens is impaired in murine leukocyte-adhesion deficiency-1 revealing elevated activation thresholds in vivo. Clin Dev Immunol. 2012;2012:450738 pubmed publisher
..Our findings may stimulate further studies on a modification of vaccination strategies using highly haptenated antigens in individuals suffering from LAD1. ..
Forster I, Muller W, Schittek B, Rajewsky K. Generation of long-lived B cells in germ-free mice. Eur J Immunol. 1991;21:1779-82 pubmed
..The data indicate that a stable pool of peripheral B cells is generated even in the absence of microbial stimulation. ..
Muller W, Kuhn R, Rajewsky K. Major histocompatibility complex class II hyperexpression on B cells in interleukin 4-transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia. Eur J Immunol. 1991;21:921-5 pubmed
..From these experiments we conclude that Ia hyperexpression on B cells per se does not induce activation of autoreactive T cells leading to B cell proliferation or hypergammaglobulinemia. ..
Birke C, Peter H, Langenberg U, Müller Hermes W, Peters J, Heitmann J, et al
. Mycoplasma contamination in human tumor cell lines: effect on interferon induction and susceptibility to natural killing. J Immunol. 1981;127:94-8 pubmed
..Possible implications of these findings for the biologic significance of the NK reaction are discussed. ..
Hirota H, Chen J, Betz U, Rajewsky K, Gu Y, Ross J, et al
. Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell. 1999;97:189-98 pubmed
..Thus, cardiac myocyte apoptosis is a critical point in the transition between compensatory cardiac hypertrophy and heart failure. gp130-dependent cytokines may represent a novel therapeutic strategy for preventing in vivo heart failure. ..
Kuklin N, Rott L, Darling J, Campbell J, Franco M, Feng N, et al
. alpha(4)beta(7) independent pathway for CD8(+) T cell-mediated intestinal immunity to rotavirus. J Clin Invest. 2000;106:1541-52 pubmed
..Thus, alpha(4)ss(7) facilitates normal intestinal immune trafficking to the gut, but it is not required for effective CD8(+) T cell immunity. ..
Händel U, Brunn A, Drögemüller K, Muller W, Deckert M, Schluter D. Neuronal gp130 expression is crucial to prevent neuronal loss, hyperinflammation, and lethal course of murine Toxoplasma encephalitis. Am J Pathol. 2012;181:163-73 pubmed publisher
..Collectively, these findings indicate a crucial protective function of gp130-expressing neurons in a model of chronic encephalitis. ..
Schwarz T, Remer K, Nahrendorf W, Masic A, Siewe L, Muller W, et al
. T cell-derived IL-10 determines leishmaniasis disease outcome and is suppressed by a dendritic cell based vaccine. PLoS Pathog. 2013;9:e1003476 pubmed publisher
..Taken together, IL-10 secretion by T cells has an influence on immune activation early after infection and is sufficient to render BALB/c mice susceptible to an uncontrolled Leishmania major infection. ..
Stewart C, Metheny H, Iida N, Smith L, Hanson M, Steinhagen F, et al
. Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation. J Clin Invest. 2013;123:4859-74 pubmed
..Therapeutic interference of this network could therefore have the undesirable consequence of promoting Th17 inflammation and cancer growth. ..
Novobrantseva T, Martin V, Pelanda R, Muller W, Rajewsky K, Ehlich A. Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice. J Exp Med. 1999;189:75-88 pubmed
..In addition, we show that in B cell progenitors VkappaJkappa joining rapidly initiates kappa chain expression, irrespective of the presence of a mu chain. ..
Hafner M, Wenk J, Nenci A, Pasparakis M, Scharffetter Kochanek K, Smyth N, et al
. Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein. Genesis. 2004;38:176-81 pubmed
Auwerx J, Avner P, Baldock R, Ballabio A, Balling R, Barbacid M, et al
. The European dimension for the mouse genome mutagenesis program. Nat Genet. 2004;36:925-7 pubmed
..The combined efforts will accelerate our understanding of gene function and of human health and disease. ..
Retter I, Chevillard C, Scharfe M, Conrad A, Hafner M, Im T, et al
. Sequence and characterization of the Ig heavy chain constant and partial variable region of the mouse strain 129S1. J Immunol. 2007;179:2419-27 pubmed
..Taken together, the contiguous genomic sequence of the 3' part of the Igh(a) locus allows a detailed view of the recent evolution of this highly dynamic locus in the mouse. ..
Fasnacht N, Muller W. Conditional gp130 deficient mouse mutants. Semin Cell Dev Biol. 2008;19:379-84 pubmed publisher
..Here, we summarize the experimental results of the conditional gp130 mutants published so far. ..
Ueki Y, Le Y, Chollangi S, Muller W, Ash J. Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors. Proc Natl Acad Sci U S A. 2009;106:21389-94 pubmed publisher
Ehlich A, Schaal S, Gu H, Kitamura D, Muller W, Rajewsky K. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell. 1993;72:695-704 pubmed
..We show that neither the pre-B cell receptor complex nor any gene rearrangement in the heavy chain locus is required for the induction of kappa light chain gene rearrangement in early B cell progenitors. ..
Bollati Fogolin M, Muller W. Virus free, cell-based assay for the quantification of murine type I interferons. J Immunol Methods. 2005;306:169-75 pubmed
..The percentage of eGFP expressing cells accurately correlates to the amount of type I IFN added to the culture and can easily be monitored. ..
Behrendt R, Schumann T, Gerbaulet A, Nguyen L, Schubert N, Alexopoulou D, et al
. Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response. Cell Rep. 2013;4:689-96 pubmed publisher
..SAMHD1-deficient mice may be instrumental for elucidating the mechanisms that trigger pathogenic type I IFN responses in AGS and SLE. ..
Ohyagi H, Onai N, Sato T, Yotsumoto S, Liu J, Akiba H, et al
. Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. Immunity. 2013;39:584-98 pubmed publisher
..This sheds light on the physiological relevance of hemophagocytosis in severe inflammatory and infectious diseases. ..
Livermore J, Howard S, Sharp A, Goodwin J, Gregson L, Felton T, et al
. Efficacy of an abbreviated induction regimen of amphotericin B deoxycholate for cryptococcal meningoencephalitis: 3 days of therapy is equivalent to 14 days. MBio. 2014;5:e00725-13 pubmed publisher
..A 3-day regimen is as effective as the standard 14-day course. An abbreviated regimen is significantly more feasible and may enable better antifungal therapy to be administered to many patients with this frequently lethal disease. ..
Forster I, Gu H, Muller W, Schmitt M, Tarlinton D, Rajewsky K. CD5 B cells in the mouse. Curr Top Microbiol Immunol. 1991;173:247-51 pubmed
Carrera L, Gazzinelli R, Badolato R, Hieny S, Muller W, Kuhn R, et al
. Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice. J Exp Med. 1996;183:515-26 pubmed
Schultz C, Rothman P, Kuhn R, Kehry M, Muller W, Rajewsky K, et al
. T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells. J Immunol. 1992;149:60-4 pubmed
..These findings provide a mechanism for previously observed IL-4-independent isotype switching to IgG1. ..
Kuhn R, Rajewsky K, Muller W. Generation and analysis of interleukin-4 deficient mice. Science. 1991;254:707-10 pubmed
..Thus, some but not all of the in vitro properties of IL-4 are critical for the physiology of the immune system in vivo. ..
Peters J, Müller Hermes W. Intercellular communication and cell cooperation in growth control of T-lymphocytes. Biophys Struct Mech. 1982;9:125-30 pubmed
Sadlack B, Kuhn R, Schorle H, Rajewsky K, Muller W, Horak I. Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4. Eur J Immunol. 1994;24:281-4 pubmed
..Paradoxically, proliferation of T cells was increased in both IL-2 and IL-4-deficient homozygous mice. ..
Bachmann M, Schorle H, Kuhn R, Muller W, Hengartner H, Zinkernagel R, et al
. Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4. J Virol. 1995;69:4842-6 pubmed
Beissert S, Hosoi J, Kuhn R, Rajewsky K, Muller W, Granstein R. Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice. J Invest Dermatol. 1996;107:553-7 pubmed
Wuestefeld T, Klein C, Streetz K, Betz U, Lauber J, Buer J, et al
. Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration. J Biol Chem. 2003;278:11281-8 pubmed
..Thus our results suggest that the role of gp130-dependent signaling is not a direct influence on cell cycle progression after partial hepatectomy but is to activate protective pathways important to enable hepatocyte proliferation. ..
Strassburger M, Bloch W, Sulyok S, Schüller J, Keist A, Schmidt A, et al
. Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Free Radic Biol Med. 2005;38:1458-70 pubmed
..This model may be particularly suited to long-term studies on age-related heart failure as well as other age-related diseases and the polygenic base of tissue-specific responses to oxidative injury. ..
Lutz J, Muller W, Jack H. VH replacement rescues progenitor B cells with two nonproductive VDJ alleles. J Immunol. 2006;177:7007-14 pubmed
..In conclusion, VH replacement can occur in the absence of a muH chain signal and provides a potential rescue mechanism for pro-B cells with two nonproductive IgH alleles. ..
Rastelli J, Hömig Hölzel C, Seagal J, Muller W, Hermann A, Rajewsky K, et al
. LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1. Blood. 2008;111:1448-55 pubmed
..Thus, our data indicate that LMP1 has evolved to imitate T-helper cell function allowing activation, proliferation, and differentiation of EBV-infected B cells independent of T cells. ..
Gerbaulet A, Wickenhauser C, Scholten J, Peschke K, Drube S, Horny H, et al
. Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit. Blood. 2011;117:2012-21 pubmed publisher
..Our findings demonstrate that the effects of constitutive kit signaling critically depend on the developmental stage and the state of differentiation of the cell hit by the gain-of-function mutation. ..
Hadis U, Wahl B, Schulz O, Hardtke Wolenski M, Schippers A, Wagner N, et al
. Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity. 2011;34:237-46 pubmed publisher
..We propose a model of stepwise oral tolerance induction comprising the generation of Treg cells in the gut-draining lymph nodes, followed by migration into the gut and subsequent expansion of Treg cells driven by intestinal macrophages...
Muller W, Ruther U, Vieira P, Hombach J, Reth M, Rajewsky K. Membrane-bound IgM obstructs B cell development in transgenic mice. Eur J Immunol. 1989;19:923-8 pubmed
..In the bone marrow B cells are almost completely depleted. A B cell population characterized by reduced levels of IgD on the cell surface is enriched in the spleen and present at almost normal levels in the peritoneum of T micron mice. ..
Sarnacki S, Auber F, Cretolle C, Camby C, Cavazzana Calvo M, Muller W, et al
. Blockade of the integrin alphaLbeta2 but not of integrins alpha4 and/or beta7 significantly prolongs intestinal allograft survival in mice. Gut. 2000;47:97-104 pubmed
Rubtsov Y, Rasmussen J, Chi E, Fontenot J, Castelli L, Ye X, et al
. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 2008;28:546-58 pubmed publisher
..Furthermore, these mechanisms are likely to be nonredundant, in that a distinct suppressor mechanism most likely plays a prominent and identifiable role at a particular tissue and inflammatory setting. ..
Haroon F, Drögemüller K, Händel U, Brunn A, Reinhold D, Nishanth G, et al
. Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation. J Immunol. 2011;186:6521-31 pubmed publisher
Tarakhovsky A, Kanner S, Hombach J, Ledbetter J, Muller W, Killeen N, et al
. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science. 1995;269:535-7 pubmed
..These observations indicate that CD5 can influence the fate of developing thymocytes by acting as a negative regulator of TCR-mediated signal transduction. ..
Kitamura D, Kudo A, Schaal S, Muller W, Melchers F, Rajewsky K. Pillars article: a critical role of lambda 5 protein in B cell development. Cell. 1992. 69: 823-831. J Immunol. 2010;184:1130-8 pubmed
Miltenyi S, Muller W, Weichel W, Radbruch A. High gradient magnetic cell separation with MACS. Cytometry. 1990;11:231-8 pubmed
..Magnetic tagging and separation does not affect cell viability and proliferation. ..
Lefranc M, Giudicelli V, Ginestoux C, Bodmer J, Muller W, Bontrop R, et al
. IMGT, the international ImMunoGeneTics database. Nucleic Acids Res. 1999;27:209-12 pubmed
..IMGT is freely available at http://imgt.cnusc. fr:8104 ..
Artis D, Humphreys N, Potten C, Wagner N, Muller W, McDermott J, et al
. Beta7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection. Eur J Immunol. 2000;30:1656-64 pubmed
..Furthermore, these results suggest that beta7 integrin-independent adhesion molecule interactions are deployed in the large but not small intestine during intestinal inflammation. ..
Peters T, Bloch W, Wickenhauser C, Tawadros S, Oreshkova T, Kess D, et al
. Terminal B cell differentiation is skewed by deregulated interleukin-6 secretion in beta2 integrin-deficient mice. J Leukoc Biol. 2006;80:599-607 pubmed
..It may be of interest to examine human leukocyte-adhesion deficiency type-1 patients closer and search for pathological changes possibly induced via overproduction of IL-6. ..
Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, et al
. EuroPhenome: a repository for high-throughput mouse phenotyping data. Nucleic Acids Res. 2010;38:D577-85 pubmed publisher
..To assist with data definition and cross-database comparisons, phenotype data is annotated using combinations of terms from biological ontologies. ..
Chaudhry A, Samstein R, Treuting P, Liang Y, Pils M, Heinrich J, et al
. Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity. 2011;34:566-78 pubmed publisher
..Thus, Treg cells limit Th17 cell inflammation by serving as principal amplifiers of negative regulatory circuits operating in immune effector cells. ..
Sledzińska A, Hemmers S, Mair F, Gorka O, Ruland J, Fairbairn L, et al
. TGF-? signalling is required for CD4? T cell homeostasis but dispensable for regulatory T cell function. PLoS Biol. 2013;11:e1001674 pubmed publisher
..In summary, absence of TGF-? signalling on mature CD4? T cells is not responsible for breakdown of peripheral tolerance, but rather controls homeostasis of mature T cells in adult mice. ..
Tesch H, Smith F, Müller Hermes W, Rajewsky K. Heterogeneous and monoclonal helper T cells induce similar anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibody populations in the primary adoptive response. I. Isotype distribution. Eur J Immunol. 1984;14:188-94 pubmed
Rajewsky K, Gu H, Kuhn R, Betz U, Muller W, Roes J, et al
. Conditional gene targeting. J Clin Invest. 1996;98:600-3 pubmed
Kida H, Mucenski M, Thitoff A, Le Cras T, Park K, Ikegami M, et al
. GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am J Pathol. 2008;172:1542-54 pubmed publisher
..In the present study, we show that GP130-STAT3 signaling functions in a cell-autonomous manner to restore cell shape and numbers required for repair of the bronchiolar epithelium following injury. ..
Frommer F, Heinen T, Wunderlich F, Yogev N, Buch T, Roers A, et al
. Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion. J Immunol. 2008;181:5748-59 pubmed
..In contrast, the T cells became sensitive to Ag-induced cell death. Our results demonstrate that B cells participate in the homeostasis of the immune system by ablation of conventional self-reactive T cells. ..
Gazzinelli R, Hayashi S, Wysocka M, Carrera L, Kuhn R, Muller W, et al
. Role of IL-12 in the initiation of cell mediated immunity by Toxoplasma gondii and its regulation by IL-10 and nitric oxide. J Eukaryot Microbiol. 1994;41:9S pubmed
Davidson N, Leach M, Fort M, Thompson Snipes L, Kuhn R, Muller W, et al
. T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J Exp Med. 1996;184:241-51 pubmed
..We thus conclude that colitis in IL-10-/- mice is predominantly mediated by TH1-type alpha beta TCR+ T cells expressing CD4 alone, or in combination with the CD8 alpha molecule. ..
Lacki J, Klama K, Porawska W, Mackiewicz S, Muller W, Wiktorowicz K. Interleukin 10 inhibits interleukin 6 production and acute phase response in rheumatoid arthritis. Arch Immunol Ther Exp (Warsz). 1995;43:11-4 pubmed
..05) and ACT (r = -0.37, p < 0.05) was also shown. According to the data thus far obtained it seems that IL-10 decreases IL-6 production, and by that indirectly affects acute phase response, decreasing CRP, AGP and ACT synthesis. ..
Sander L, Obermeier F, Dierssen U, Kroy D, Singh A, Seidler U, et al
. Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation. J Immunol. 2008;181:3586-94 pubmed
..We provide evidence that IL-6 cytokines acting via gp130 are required in the acute stages of intestinal inflammation by modulating the dynamics of innate immune cell recruitment and activation. ..
Tesch H, Muller W, Rajewsky K. Lymphokines regulate immunoglobulin isotype expression in an antigen-specific immune response. J Immunol. 1986;136:2892-5 pubmed
..These results suggest that these lymphokines (and perhaps additional ones) are involved in the control of isotype expression in antigen-specific responses. ..
Ruther U, Muller W, Sumida T, Tokuhisa T, Rajewsky K, Wagner E. c-fos expression interferes with thymus development in transgenic mice. Cell. 1988;53:847-56 pubmed
..B and T cell function, however, is impaired, and H2-c-fos mice are immune deficient. It appears that c-fos specifically stimulates the proliferation of thymic epithelial cells, and may thus indirectly affect T cell development. ..
Muller W. A genetic approach for the analysis of cytokine function in vivo. Behring Inst Mitt. 1995;:95-6 pubmed
Berg D, Kuhn R, Rajewsky K, Muller W, Menon S, Davidson N, et al
. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest. 1995;96:2339-47 pubmed
..These results show that IL-10 is a critical component of the host's natural defense against the development of pathologic responses to LPS although it is not responsible for LPS-induced tolerance. ..
Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 1993;75:263-74 pubmed
..These results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract. ..
Carrera L, Chiaramonte M, Kuhn R, Muller W, Sacks D, Sher A, et al
. Leishmania major and Toxoplasma gondii have opposite effects on cytokine synthesis by macrophages. Mem Inst Oswaldo Cruz. 1994;89:649-50 pubmed
Morawetz R, Gabriele L, Rizzo L, Noben Trauth N, Kuhn R, Rajewsky K, et al
. Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse. J Exp Med. 1996;184:1651-61 pubmed
..This pathway appears to be dependent on distinct factors that separately control induction of g epsilon transcription and switch recombination to p epsilon. ..
Betz U, Bloch W, van Den Broek M, Yoshida K, Taga T, Kishimoto T, et al
. Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects. J Exp Med. 1998;188:1955-65 pubmed
..Such conditional mutant mice exhibited neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects, demonstrating the widespread importance of gp130-dependent cytokines. ..