Anil Mehta

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc The European Cystic Fibrosis Society Patient Registry: valuable lessons learned on how to sustain a disease registry
    Laura Viviani
    Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
    Orphanet J Rare Dis 9:81. 2014
  2. pmc Reference percentiles for FEV(1) and BMI in European children and adults with cystic fibrosis
    Pierre Yves Boelle
    AP HP, Hôpital Trousseau Pediatric Pulmonary Department, Hopital St Antoine Public Health Department, Paris, France
    Orphanet J Rare Dis 7:64. 2012
  3. pmc Understanding protein kinase CK2 mis-regulation upon F508del CFTR expression
    Andrea Venerando
    Department of Biological Chemistry and CNR Institute of Neurosciences, University of Padova, Viale G Colombo 3, 35131, Padua, Italy
    Naunyn Schmiedebergs Arch Pharmacol 384:473-88. 2011
  4. pmc Nucleoside diphosphate kinase A as a controller of AMP-kinase in airway epithelia
    Richmond Muimo
    Academic Unit of Child Health, Stephenson Wing, Sheffield Children s Hospital, Sheffield, S10 2TH, UK
    J Bioenerg Biomembr 38:181-7. 2006
  5. pmc A methodology to establish a database to study gene environment interactions for childhood asthma
    Stephen W Turner
    Academic Child Health, University of Aberdeen, Aberdeen, UK
    BMC Med Res Methodol 10:107. 2010
  6. ncbi request reprint CFTR: more than just a chloride channel
    Anil Mehta
    Division of Maternal and Child Health Sciences, Ninewells Hospital Medical School, Dundee, Scotland, UK
    Pediatr Pulmonol 39:292-8. 2005
  7. pmc Nucleoside diphosphate kinase (NDPK, NM23, AWD): recent regulatory advances in endocytosis, metastasis, psoriasis, insulin release, fetal erythroid lineage and heart failure; translational medicine exemplified
    Anil Mehta
    Division of Medical Sciences, Tayside Institute of Child Health, Ninewells Hospital Medical School, Dundee DD19SY, Scotland, UK
    Mol Cell Biochem 329:3-15. 2009
  8. pmc Cystic fibrosis as a bowel cancer syndrome and the potential role of CK2
    Anil Mehta
    Division of Maternal and Child Health Sciences, Ninewells Hospital, University of Dundee, Dundee, DD1 9SY, UK
    Mol Cell Biochem 316:169-75. 2008
  9. doi request reprint The how (and why) of disease registers
    Anil Mehta
    Ninewells Hospital, University of Dundee, UK
    Early Hum Dev 86:723-8. 2010
  10. ncbi request reprint Beyond chloride transport: CFTR in the 21st century-introductory remarks to a new state of the art series
    Anil Mehta
    UK Cystic Fibrosis Database, Ninewells Hospital Medical School, Dundee, Scotland, UK
    Pediatr Pulmonol 39:289-91. 2005

Collaborators

Detail Information

Publications47

  1. pmc The European Cystic Fibrosis Society Patient Registry: valuable lessons learned on how to sustain a disease registry
    Laura Viviani
    Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
    Orphanet J Rare Dis 9:81. 2014
    ....
  2. pmc Reference percentiles for FEV(1) and BMI in European children and adults with cystic fibrosis
    Pierre Yves Boelle
    AP HP, Hôpital Trousseau Pediatric Pulmonary Department, Hopital St Antoine Public Health Department, Paris, France
    Orphanet J Rare Dis 7:64. 2012
    ..Here, we used a large database of European CF patients to compute CF specific reference equations for FEV(1) and BMI, derived CF-specific percentile charts and compared these European data to their nearest international equivalents...
  3. pmc Understanding protein kinase CK2 mis-regulation upon F508del CFTR expression
    Andrea Venerando
    Department of Biological Chemistry and CNR Institute of Neurosciences, University of Padova, Viale G Colombo 3, 35131, Padua, Italy
    Naunyn Schmiedebergs Arch Pharmacol 384:473-88. 2011
    ..We conclude that a latent path may exist between mutation of this conserved sequence, CK2 hyperactivity and disease pathogenesis that might also explain the heterozygote advantage for the common F508del CFTR mutant...
  4. pmc Nucleoside diphosphate kinase A as a controller of AMP-kinase in airway epithelia
    Richmond Muimo
    Academic Unit of Child Health, Stephenson Wing, Sheffield Children s Hospital, Sheffield, S10 2TH, UK
    J Bioenerg Biomembr 38:181-7. 2006
    ..Thus we propose a novel paradigm in NDPK-A function by suggesting that AMP-kinase can be regulated by NDPK-A, independently of AMP...
  5. pmc A methodology to establish a database to study gene environment interactions for childhood asthma
    Stephen W Turner
    Academic Child Health, University of Aberdeen, Aberdeen, UK
    BMC Med Res Methodol 10:107. 2010
    ..Here, we describe the methodology and experiences in establishing a database for childhood asthma designed to study gene-environment interactions (PAGES--Paediatric Asthma Gene Environment Study)...
  6. ncbi request reprint CFTR: more than just a chloride channel
    Anil Mehta
    Division of Maternal and Child Health Sciences, Ninewells Hospital Medical School, Dundee, Scotland, UK
    Pediatr Pulmonol 39:292-8. 2005
    ....
  7. pmc Nucleoside diphosphate kinase (NDPK, NM23, AWD): recent regulatory advances in endocytosis, metastasis, psoriasis, insulin release, fetal erythroid lineage and heart failure; translational medicine exemplified
    Anil Mehta
    Division of Medical Sciences, Tayside Institute of Child Health, Ninewells Hospital Medical School, Dundee DD19SY, Scotland, UK
    Mol Cell Biochem 329:3-15. 2009
    ..This is immediately followed by examples of the diverse biology generated by this self-aggregating group of multi-functional proteins and finally capped by an emerging idea explaining how this diversity might arise...
  8. pmc Cystic fibrosis as a bowel cancer syndrome and the potential role of CK2
    Anil Mehta
    Division of Maternal and Child Health Sciences, Ninewells Hospital, University of Dundee, Dundee, DD1 9SY, UK
    Mol Cell Biochem 316:169-75. 2008
    ..The emerging idea is that CFTR may control membrane-CK2 as much as membrane-CK2 controls CFTR...
  9. doi request reprint The how (and why) of disease registers
    Anil Mehta
    Ninewells Hospital, University of Dundee, UK
    Early Hum Dev 86:723-8. 2010
    ..Should these links fail, they have the potential to delay the entry of a screened baby into therapy after testing positive for a preventable disease...
  10. ncbi request reprint Beyond chloride transport: CFTR in the 21st century-introductory remarks to a new state of the art series
    Anil Mehta
    UK Cystic Fibrosis Database, Ninewells Hospital Medical School, Dundee, Scotland, UK
    Pediatr Pulmonol 39:289-91. 2005
    ..These themes have been chosen to bring controversies at the cutting edge of cystic fibrosis research to the practicing pulmonologist in order to stimulate lateral thinking, which we hope will ultimately benefit our patients...
  11. pmc The cystic fibrosis transmembrane recruiter the alter ego of CFTR as a multi-kinase anchor
    Anil Mehta
    Department of Maternal and Child Health Sciences, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, UK
    Pflugers Arch 455:215-21. 2007
    ..Crucially, a new role for CFTR as a kinase controller is proposed with ionic concentration acting as a signal. The model posits a regulatory control relay for energy sensing involving a cascade of protein kinases bound to CFTR...
  12. ncbi request reprint A global perspective on newborn screening for cystic fibrosis
    Anil Mehta
    Division of Maternal and Child Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Curr Opin Pulm Med 13:510-4. 2007
    ..The review is written to address the concerns of the sceptics...
  13. ncbi request reprint Neonatal screening for cystic fibrosis is beneficial even in the context of modern treatment
    Erika J Sims
    United Kingdom Cystic Fibrosis Database, Division of Maternal and Child Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
    J Pediatr 147:S42-6. 2005
    ....
  14. ncbi request reprint NDPK-A (but not NDPK-B) and AMPK alpha1 (but not AMPK alpha2) bind the cystic fibrosis transmembrane conductance regulator in epithelial cell membranes
    Russell M Crawford
    Department of Maternal and Child Health Sciences, University of Dundee, Ninewells Hospital, Dundee, DD1 9SY, UK
    Cell Signal 18:1595-603. 2006
    ..Thus, the combined data provide novel insight into the subunit composition of the epithelial CFTR/AMPK/NDPK complex, such that: CFTR interacts specifically with AMPK alpha1, gamma2 and NDPK-A and not NDPK-B or AMPK gamma1...
  15. ncbi request reprint Protein kinase CK2 acts as a signal molecule switching between the NDPK-A/AMPK alpha1 complex and NDPK-B
    Russell M Crawford
    Division of Maternal and Child Health Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    FASEB J 21:88-98. 2007
    ..This study also offers an explanation as to how CK2alpha exclusion mutations (S120A or S122D of NDPK-A) on NDPK-A might have implications in cancer biology and general cellular energy metabolism...
  16. ncbi request reprint Cystic fibrosis diagnosed after 2 months of age leads to worse outcomes and requires more therapy
    Erika J Sims
    United Kingdom Cystic Fibrosis Database, Division of Maternal and Child Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
    Pediatrics 119:19-28. 2007
    ....
  17. pmc Inhibition of protein kinase CK2 closes the CFTR Cl channel, but has no effect on the cystic fibrosis mutant deltaF508-CFTR
    Kate J Treharne
    Centre for Cardiovascular and Lung Biology, University of Dundee, Ninewells Hospital, UK
    Cell Physiol Biochem 24:347-60. 2009
    ..The surface location of F508 on NBD1 creates the potential for protein-protein interactions and nearby, lies a consensus sequence (SYDE) reported to control the pleiotropic protein kinase CK2...
  18. ncbi request reprint Protein kinase CK2, cystic fibrosis transmembrane conductance regulator, and the deltaF508 mutation: F508 deletion disrupts a kinase-binding site
    Kate J Treharne
    Department of Maternal and Child Health Sciences, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 282:10804-13. 2007
    ..Disruption of this CK2-CFTR association is the first described DeltaF508-dependent protein-protein interaction that provides a new molecular paradigm in the most frequent form of cystic fibrosis...
  19. pmc Epithelial IgG and its relationship to the loss of F508 in the common mutant form of the cystic fibrosis transmembrane conductance regulator
    Kate J Treharne
    Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    FEBS Lett 583:2493-9. 2009
    ..Further, our data show that the amino-acid sequence local to F508 can bind IgG with high affinity, dependent on F508, such that loss of F508 abolishes this link both in vitro and in the intact cell...
  20. pmc Understanding the molecular basis of the interaction between NDPK-A and AMPK alpha 1
    Russell M Crawford
    Department of Maternal and Child Health Sciences, University of Dundee, Dundee DD1 9SY, United Kingdom
    Mol Cell Biol 26:5921-31. 2006
    ..We report the cellular effects of the S122 mutation on ACC1 phosphorylation and demonstrate that the presence of E124 (absent in NDPK-B) is necessary and sufficient to permit both AMPK alpha1 binding and substrate channeling...
  21. pmc Cystic fibrosis transmembrane regulator fragments with the Phe508 deletion exert a dual allosteric control over the master kinase CK2
    Mario A Pagano
    Department of Biological Chemistry and CNR Institute of Neurosciences, University of Padova, Viale G Colombo 3, 35131 Padova, Italy
    Biochem J 426:19-29. 2010
    ....
  22. pmc Detection of phospho-sites generated by protein kinase CK2 in CFTR: mechanistic aspects of Thr1471 phosphorylation
    Andrea Venerando
    Department of Biomedical Sciences, University of Padova, and CNR Institute of Neurosciences, Padova, Italy
    PLoS ONE 8:e74232. 2013
    ....
  23. pmc Modulation of protein kinase CK2 activity by fragments of CFTR encompassing F508 may reflect functional links with cystic fibrosis pathogenesis
    Mario A Pagano
    Department of Biological Chemistry and CNR Institute of Neurosciences, University of Padova, Viale G Colombo 3, 35131 Padova, Italy
    Biochemistry 47:7925-36. 2008
    ....
  24. doi request reprint Defective formation of PKA/CnA-dependent annexin 2-S100A10/CFTR complex in DeltaF508 cystic fibrosis cells
    Lee Anthony Borthwick
    Academic Unit of Child Health, The University of Sheffield, Sheffield Children s, Hospital, Stephenson Wing, Sheffield, S10 2TH, UK
    Cell Signal 20:1073-83. 2008
    ..Thus, we demonstrate that cAMP/PKA/CnA signaling pathway is defective in CF cells and suggest that loss of anx 2-S100A10/CFTR complex formation may contribute to defective cAMP/PKA-dependent CFTR channel function...
  25. ncbi request reprint Economic implications of newborn screening for cystic fibrosis: a cost of illness retrospective cohort study
    Erika J Sims
    UK Cystic Fibrosis Database, Division of Maternal and Child Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Lancet 369:1187-95. 2007
    ..Compared with clinical diagnosis, newborn screening is associated with clinical benefit and reduced treatment needs. We estimate the potential savings in treatment costs attributable to newborn screening...
  26. ncbi request reprint Comparative analysis of Cystic Fibrosis Registry data from the UK with USA, France and Australasia
    Jonathan McCormick
    United Kingdom Cystic Fibrosis Database, Tayside Institute of Child Health, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK DD1 9SY
    J Cyst Fibros 4:115-22. 2005
    ..Using the UK Cystic Fibrosis Database, we analysed the health of the UK CF paediatric population (UKPP) in terms of their biographical, clinical and infection status and compared outcomes with the US, French and Australasian CF Registries...
  27. pmc Expression of wild-type CFTR suppresses NF-kappaB-driven inflammatory signalling
    Mairi J Hunter
    Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    PLoS ONE 5:e11598. 2010
    ..CF-inflammation provides one example but its pathogenesis remains controversial. Here, we tested the simple but fundamental hypothesis that wild-type CFTR is needed to suppress NF-kappaB activity...
  28. pmc A novel physical and functional association between nucleoside diphosphate kinase A and AMP-activated protein kinase alpha1 in liver and lung
    Russell M Crawford
    Department of Maternal and Child Health Sciences, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, UK
    Biochem J 392:201-9. 2005
    ..Thus novel NM23-H1/NDPK A-dependent regulation of AMPK alpha1-mediated phosphorylation is present in mammalian cells...
  29. pmc The phosphorylation status of membrane-bound nucleoside diphosphate kinase in epithelia and the role of AMP
    Kate J Treharne
    Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee DD19SY, UK
    Mol Cell Biochem 329:107-14. 2009
    ..Although histidine phosphorylation should in principle be independent of the nucleotide triphosphates used, we speculate that this membrane pool of NDPK may be able to switch function dependent on nucleotide species...
  30. ncbi request reprint Decreased lung function in female but not male subjects with established cystic fibrosis-related diabetes
    Erika J Sims
    Division of Maternal and Child Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Diabetes Care 28:1581-7. 2005
    ..This study examines the association between female subjects with CFRD and poor lung function relative to male subjects using the percent predicted forced expiratory volume in 1 s (FEV(1)) as a surrogate measure of morbidity...
  31. doi request reprint Cystic fibrosis across Europe: EuroCareCF analysis of demographic data from 35 countries
    Gita Mehta
    Division of Medical Sciences, University of Dundee, Dundee, UK
    J Cyst Fibros 9:S5-S21. 2010
    ..A 35-country European cystic fibrosis (CF) demographic registry was developed to compare outcomes (EuroCareCF EC-FP6)...
  32. ncbi request reprint Delayed diagnosis of females with respiratory presentation of cystic fibrosis did not segregate with poorer clinical outcome
    Jonathan McCormick
    Maternal and Child Health Sciences, Ninewells Hospital and Medical School, Dundee, Scotland DD1 9SY, United Kingdom
    J Clin Epidemiol 59:315-22. 2006
    ..Does a delay in diagnosis exist in females with cystic fibrosis (CF) presenting with respiratory symptoms alone. Does it segregate with poorer clinical outcomes?..
  33. ncbi request reprint Newborn screening for cystic fibrosis is associated with reduced treatment intensity
    Erika J Sims
    United Kingdom Cystic Fibrosis Database, Division of Maternal and Child Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom
    J Pediatr 147:306-11. 2005
    ..To determine whether the improved clinical status after newborn screening (NBS) for cystic fibrosis (CF) segregates with increased therapeutic intervention compared with presentation by clinical diagnosis (CD)...
  34. ncbi request reprint Asians with cystic fibrosis in the UK have worse disease outcomes than clinic matched white homozygous delta F508 controls
    Jonathan McCormick
    United Kingdom Cystic Fibrosis Database, Maternal and Child Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland DD1 9SY, United Kingdom
    J Cyst Fibros 4:53-8. 2005
    ..We tested the hypothesis that the Asian cystic fibrosis (CF) phenotype is comparable to the commonest genetic form of CF found in 50% of the white UK CF population using the UK CF Database, a national disease-specific patient registry...
  35. ncbi request reprint Overweight and obesity in deltaF508 homozygous cystic fibrosis
    Dagmar Kastner-Cole
    Division of Maternal and Child Health Sciences, Institute of Cardiovascular Research and Biomedical Research Centre, Ninewells Hospital, Dundee, Scotland, United Kingdom
    J Pediatr 147:402-4. 2005
    ..Children with CFdeltaF508, in contrast to the general population, showed a positive association between body mass index and lung function for all body mass index z-scores...
  36. ncbi request reprint Making human nasal cilia beat in the cold: a real time assay for cell signalling
    Xowi K M S Mwimbi
    Tayside Institute of Child Health Centre for Research into Human Development, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    Cell Signal 15:395-402. 2003
    ..These findings may relate to adaptive responses to cold climates...
  37. pmc Transglutaminase 2 and nucleoside diphosphate kinase activity are correlated in epithelial membranes and are abnormal in cystic fibrosis
    Kate J Treharne
    Centre for Cardiovascular and Lung Biology, Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, United Kingdom
    FEBS Lett 583:2789-92. 2009
    ..We find that NDPK function is abnormally low in cystic fibrosis but can be restored by RA treatment in vitro. Our data suggest that tgase2 is overexpressed in cystic fibrosis and affects NDPK function...
  38. doi request reprint Comparative demographics of the European cystic fibrosis population: a cross-sectional database analysis
    Jonathan McCormick
    Centre for Academic Clinical Practice, Division of Clinical Population Science and Education, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Lancet 375:1007-13. 2010
    ....
  39. pmc The formation of the cAMP/protein kinase A-dependent annexin 2-S100A10 complex with cystic fibrosis conductance regulator protein (CFTR) regulates CFTR channel function
    Lee A Borthwick
    Academic Unit of Child Health, The University of Sheffield, Sheffield Children s Hospital, Sheffield, S10 2TH, United Kingdom
    Mol Biol Cell 18:3388-97. 2007
    ..Furthermore, peptide Ac1-14 inhibited acetylcholine-induced short-circuit current measured across a sheet of intact intestinal biopsy. Our data suggests that the anx 2-S100A10/CFTR complex is important for CFTR function across epithelia...
  40. ncbi request reprint Fertility and pregnancy outcomes in men and women with cystic fibrosis in the United Kingdom
    Jenny M Boyd
    Women s and Child Health, Ninewells Hospital and Medical School, Dundee, United Kingdom
    Hum Reprod 19:2238-43. 2004
    ..The survival of patients with cystic fibrosis (CF) now occurs into the fourth decade of life. Our aim was to evaluate the fertility and pregnancy outcomes of men and women with cystic fibrosis within a large British cohort...
  41. pmc CFTR mutations altering CFTR fragmentation
    Kendra Tosoni
    Division of Medical Sciences, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, U K
    Biochem J 449:295-305. 2013
    ..We conclude that the F508delCFTR mutant is not degraded completely and there exists a relationship between CFTR's fragmentation fingerprint and the CFTR sequence through putative CK2-interactive sites that lie near F508...
  42. pmc Using Drugs to Probe the Variability of Trans-Epithelial Airway Resistance
    Kendra Tosoni
    Division of Cardiovascular and Diabetes Medicine, University of Dundee, Medical Research Institute Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    PLoS ONE 11:e0149550. 2016
    ....
  43. ncbi request reprint 4alpha-Phorbol negates the inhibitory effects of phorbol-12-myristate-13-acetate on human cilia and alters the phosphorylation of PKC
    Xowi K M S Mwimbi
    Tayside Institute of Child Health, Ninewells Hospital and Medical School, University of Dundee, UK
    FEBS Lett 530:31-6. 2002
    ..Thus, 4alpha-phorbol not only potently prevents PMA from inhibiting CBF but also has potent effects on the phosphorylation of PKC...
  44. ncbi request reprint Demographics of the UK cystic fibrosis population: implications for neonatal screening
    Jonathan McCormick
    The UK CF Database, Tayside Institute of Child Health, Ninewells Hospital, Dundee DD1 9SY, UK
    Eur J Hum Genet 10:583-90. 2002
    ..Screen-positive, non-Caucasian infants without an identifiable CFTR mutation should be referred for a sweat test and genetic counselling when serum trypsinogen concentrations remain elevated after birth...
  45. ncbi request reprint CFTR gene transfer to human cystic fibrosis pancreatic duct cells using a Sendai virus vector
    Zoltan Rakonczay
    Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
    J Cell Physiol 214:442-55. 2008
    ..Our data show that SeV vector is a potential CFTR gene transfer agent for human pancreatic duct cells and that expression of CFTR in CF cells is associated with a restoration of Cl- and HCO3- transport at the apical membrane...
  46. ncbi request reprint Novel regulation of cystic fibrosis transmembrane conductance regulator (CFTR) channel gating by external chloride
    Angela M Wright
    Institute of Cell and Molecular Biosciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom
    J Biol Chem 279:41658-63. 2004
    ..Physiologically, our data have implications for current models of epithelial HCO(3)(-) secretion and for the control of pH at epithelial cell surfaces...
  47. pmc Regulation of the epithelial Na+ channel by the protein kinase CK2
    Tanja Bachhuber
    Institut fur Physiologie, Universitat Regensburg, Universitatsstrasse 31, D 93053 Regensburg, Germany
    J Biol Chem 283:13225-32. 2008
    ..We propose that the C terminus of beta-ENaC is targeted by this essential, conserved pleiotropic kinase that directs its constitutive activity toward many cellular protein complexes...