Debbie Anne Lawlor

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. Kipping R, Howe L, Jago R, Campbell R, Wells S, Chittleborough C, et al. Effect of intervention aimed at increasing physical activity, reducing sedentary behaviour, and increasing fruit and vegetable consumption in children: active for Life Year 5 (AFLY5) school based cluster randomised controlled trial. BMJ. 2014;348:g3256 pubmed publisher
    ..Trial registration Current Controlled Trials ISRCTN50133740. ..
  2. Lawlor D, Windmeijer F, Smith G. Is Mendelian randomization 'lost in translation?': comments on 'Mendelian randomization equals instrumental variable analysis with genetic instruments' by Wehby et al. Stat Med. 2008;27:2750-5 pubmed publisher
  3. Lawlor D, West J, Fairley L, Nelson S, Bhopal R, Tuffnell D, et al. Pregnancy glycaemia and cord-blood levels of insulin and leptin in Pakistani and white British mother-offspring pairs: findings from a prospective pregnancy cohort. Diabetologia. 2014;57:2492-500 pubmed publisher
    ..Results were very similar when 130 women with gestational diabetes were removed. These novel findings suggest a role of maternal pregnancy glycaemia in mediating differences in fat mass between Pakistani and white British infants. ..
  4. Lawlor D, Gaunt T, Hinks L, Davey Smith G, Timpson N, Day I, et al. The association of the PON1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women's Heart and Health cohort study. Paediatr Perinat Epidemiol. 2006;20:244-50 pubmed
    ..02, 1.39]. Our findings provide some further evidence to suggest that PON1 Q192R is associated with preterm birth; they invite further investigation of both maternal and fetal genotype for PON1 Q192R in relation to preterm birth. ..
  5. Lawlor D, Sattar N, Sayers A, Tobias J. The association of fasting insulin, glucose, and lipids with bone mass in adolescents: findings from a cross-sectional study. J Clin Endocrinol Metab. 2012;97:2068-76 pubmed publisher
    ..The inverse association of fasting insulin with BMD, BMC, and BA once fat mass has been controlled for needs further study. ..
  6. Au Yeung S, Borges M, Lawlor D. Association of Genetic Instrumental Variables for Lung Function on Coronary Artery Disease Risk: A 2-Sample Mendelian Randomization Study. Circ Genom Precis Med. 2018;11:e001952 pubmed publisher
    ..75-1.17). Estimates for FVC in the sensitivity analyses were attenuated (median) or changed direction (MR-Egger). Our study suggested an inverse relation between FEV1 and CAD, but for FVC, evidence is less clear. ..
  7. Sebire S, Jago R, Wood L, Thompson J, Zahra J, Lawlor D. Examining a conceptual model of parental nurturance, parenting practices and physical activity among 5-6 year olds. Soc Sci Med. 2016;148:18-24 pubmed publisher
    ..Further research examining conceptual models of parenting is needed to understand in more depth the possible antecedents to adaptive parenting practices beyond parenting styles. ..
  8. Jago R, Rawlins E, Kipping R, Wells S, Chittleborough C, Peters T, et al. Lessons learned from the AFLY5 RCT process evaluation: implications for the design of physical activity and nutrition interventions in schools. BMC Public Health. 2015;15:946 pubmed publisher
    ..However, this will require adequate funding and cost-effectiveness will need to be established. ISRCTN50133740. ..
  9. Lawlor D, Wills A, Fraser A, Sayers A, Fraser W, Tobias J. Association of maternal vitamin D status during pregnancy with bone-mineral content in offspring: a prospective cohort study. Lancet. 2013;381:2176-83 pubmed publisher
    ..We found no relevant association between maternal vitamin D status in pregnancy and offspring BMC in late childhood. UK Medical Research Council, Wellcome Trust, and University of Bristol. ..

More Information

Publications24

  1. Lawlor D, Timpson N, Ebrahim S, Day I, Smith G. The association of oestrogen receptor alpha-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study. Eur Heart J. 2006;27:1597-604 pubmed
    ..Women with the T-A haplotype are more likely to use hormone replacement. However, genotyping of ESR1 rs2234693 or rs9340799 in post-menopausal women to tailor hormone replacement is unlikely to markedly improve cardiovascular risk. ..
  2. Lawlor D, Taylor M, Bedford C, Ebrahim S. Is housework good for health? Levels of physical activity and factors associated with activity in elderly women. Results from the British Women's Heart and Health Study. J Epidemiol Community Health. 2002;56:473-8 pubmed
    ..Heavy housework is not associated with reduced levels of being overweight and prospective studies are necessary to demonstrate an independent health benefit of participating in domestic activities. ..
  3. Wang Q, Ferreira D, Nelson S, Sattar N, Ala Korpela M, Lawlor D. Metabolic characterization of menopause: cross-sectional and longitudinal evidence. BMC Med. 2018;16:17 pubmed publisher
    ..The adverse changes in multiple apolipoprotein-B-containing lipoprotein subclasses and increased inflammation may underlie women's increased cardiometabolic risk in their post-menopausal years. ..
  4. Lawlor D, Harbord R, Timpson N, Lowe G, Rumley A, Gaunt T, et al. The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants. PLoS ONE. 2008;3:e3011 pubmed publisher
    ..These findings do not support a causal association between circulating CRP and CHD risk, but very large, extended, genetic association studies would be required to rule this out. ..
  5. Lawlor D, Nordestgaard B, Benn M, Zuccolo L, Tybjaerg Hansen A, Davey Smith G. Exploring causal associations between alcohol and coronary heart disease risk factors: findings from a Mendelian randomization study in the Copenhagen General Population Study. Eur Heart J. 2013;34:2519-28 pubmed publisher
    ..Our results show adverse effects of long-term alcohol consumption on BP and BMI. We also found novel evidence for a potentially beneficial effect on triglyceride levels, which needs further replication. ..
  6. Lawlor D, Howe L, Anderson E, Kipping R, Campbell R, Wells S, et al. The Active for Life Year 5 (AFLY5) school-based cluster randomised controlled trial: effect on potential mediators. BMC Public Health. 2016;16:68 pubmed publisher
    ..Current Controlled Trials ISRCTN50133740. Registered 17/03/2011. ..
  7. Lawlor D, Morgan K, Frankel S. Caring for the health of the public: cross sectional study of the activities of UK public health departments. Public Health. 2002;116:102-5 pubmed
  8. Lawlor D, Fraser A, Lindsay R, Ness A, Dabelea D, Catalano P, et al. Association of existing diabetes, gestational diabetes and glycosuria in pregnancy with macrosomia and offspring body mass index, waist and fat mass in later childhood: findings from a prospective pregnancy cohort. Diabetologia. 2010;53:89-97 pubmed publisher
  9. Lawlor D, Fraser A, Macdonald Wallis C, Nelson S, Palmer T, Davey Smith G, et al. Maternal and offspring adiposity-related genetic variants and gestational weight gain. Am J Clin Nutr. 2011;94:149-55 pubmed publisher
    ..Our findings suggest that neither maternal nor fetal adiposity-related genetic variants are associated with greater GWG. The inverse association of maternal allele score with GWG in the first 18 wk requires replication. ..
  10. Lawlor D, Timpson N, Harbord R, Leary S, Ness A, McCarthy M, et al. Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable. PLoS Med. 2008;5:e33 pubmed publisher
    ..Developmental overnutrition related to greater maternal BMI is unlikely to have driven the recent obesity epidemic. ..
  11. Lawlor D, Day I, Gaunt T, Hinks L, Timpson N, Ebrahim S, et al. The association of the paraoxonase (PON1) Q192R polymorphism with depression in older women: findings from the British Women's Heart and Health Study. J Epidemiol Community Health. 2007;61:85-7 pubmed
    ..The possible role of PON1 Q192R in psychiatric morbidity requires further examination. ..
  12. Lawlor D, Day I, Gaunt T, Hinks L, Briggs P, Kiessling M, et al. The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis. BMC Genet. 2004;5:17 pubmed
    ..There is no robust evidence that the PON1 Q192R polymorphism is associated with CHD risk in Caucasian women or men. ..
  13. Xu L, Borges M, Hemani G, Lawlor D. The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: a two-step, two-sample Mendelian randomisation study. Diabetologia. 2017;60:2210-2220 pubmed publisher
    ..09 (95% CI 0.94, 1.27) with adjustment for both. Increased triacylglycerol levels and poor glycaemic control appear to mediate much of the effect of BMI on CHD. ..
  14. West J, Santorelli G, Whincup P, Smith L, Sattar N, Cameron N, et al. Association of maternal exposures with adiposity at age 4/5 years in white British and Pakistani children: findings from the Born in Bradford study. Diabetologia. 2018;61:242-252 pubmed publisher
    ..While maternal BMI is positively associated with offspring adiposity, gestational glycaemia is not clearly related to offspring adiposity in either ethnic group. ..