Gillian M Griffiths

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. doi request reprint Communication, the centrosome and the immunological synapse.
    Jane C Stinchcombe
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 OXY, UK
    Philos Trans R Soc Lond B Biol Sci 369:. 2014
  2. doi request reprint Open questions: missing pieces from the immunological jigsaw puzzle.
    Gillian M Griffiths
    Cambridge Institute for Medical Research, Hills Rd, Cambridge, CB2 0XY, UK
    BMC Biol 11:10. 2013
  3. pmc The immunological synapse: a focal point for endocytosis and exocytosis
    Gillian M Griffiths
    Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, England, UK
    J Cell Biol 189:399-406. 2010
  4. ncbi request reprint Gaucher disease: forging a new path to the lysosome
    Gillian M Griffiths
    Cambridge Institute for Medical Research, Wellcome MRC Building, Box 139, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0XY
    Cell 131:647-9. 2007
  5. pmc Cytotoxic T lymphocyte effector function is independent of nucleus-centrosome dissociation
    Winnie W Y Lui-Roberts
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Eur J Immunol 42:2132-41. 2012
  6. pmc Centrosome docking at the immunological synapse is controlled by Lck signaling
    Andy Tsun
    Cambridge Institute for Medical Research, Addenbrooke s Hospital, University of Cambridge, Cambridge, England, UK
    J Cell Biol 192:663-74. 2011
  7. pmc The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse
    Misty R Jenkins
    Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
    Immunity 31:621-31. 2009
  8. pmc Cell polarisation and the immunological synapse
    Karen L Angus
    Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, CB2 0XY, England, UK
    Curr Opin Cell Biol 25:85-91. 2013
  9. pmc Hedgehog signaling controls T cell killing at the immunological synapse
    Maike de la Roche
    Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
    Science 342:1247-50. 2013
  10. pmc The role of the cytoskeleton at the immunological synapse
    Alex T Ritter
    Cambridge Institute for Medical Research, University of Cambridge Biomedical Campus, Cambridge, UK
    Immunol Rev 256:107-17. 2013

Collaborators

Detail Information

Publications35

  1. doi request reprint Communication, the centrosome and the immunological synapse.
    Jane C Stinchcombe
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 OXY, UK
    Philos Trans R Soc Lond B Biol Sci 369:. 2014
    ..The features observed at the immunological synapse show parallels to centrosome (basal body) polarization seen in cilia and flagella, and the cellular communication that is now known to occur at all of these sites...
  2. doi request reprint Open questions: missing pieces from the immunological jigsaw puzzle.
    Gillian M Griffiths
    Cambridge Institute for Medical Research, Hills Rd, Cambridge, CB2 0XY, UK
    BMC Biol 11:10. 2013
  3. pmc The immunological synapse: a focal point for endocytosis and exocytosis
    Gillian M Griffiths
    Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, England, UK
    J Cell Biol 189:399-406. 2010
    ..These intriguing observations suggest that the centrosome may play a conserved role in designating a specialized area of membrane for localized endocytosis and exocytosis...
  4. ncbi request reprint Gaucher disease: forging a new path to the lysosome
    Gillian M Griffiths
    Cambridge Institute for Medical Research, Wellcome MRC Building, Box 139, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0XY
    Cell 131:647-9. 2007
    ..They show that beta-glucocerebrosidase-the lysosomal enzyme defective in patients with Gaucher disease-is delivered to the lysosome through its interaction with the transmembrane protein LIMP-2...
  5. pmc Cytotoxic T lymphocyte effector function is independent of nucleus-centrosome dissociation
    Winnie W Y Lui-Roberts
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Eur J Immunol 42:2132-41. 2012
    ..These data demonstrate that CTL cytotoxicity is independent of centrosomal dissociation from the nuclear envelope...
  6. pmc Centrosome docking at the immunological synapse is controlled by Lck signaling
    Andy Tsun
    Cambridge Institute for Medical Research, Addenbrooke s Hospital, University of Cambridge, Cambridge, England, UK
    J Cell Biol 192:663-74. 2011
    ..These results show that repositioning of the centrosome in CTLs involves at least two distinct steps, with Lck signaling required for the centrosome to dock at the plasma membrane...
  7. pmc The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse
    Misty R Jenkins
    Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
    Immunity 31:621-31. 2009
    ..By controlling centrosome and granule polarization independently, the centrosome is able to respond rapidly to weak signals so that CTLs are poised and ready for the trigger for granule delivery...
  8. pmc Cell polarisation and the immunological synapse
    Karen L Angus
    Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, CB2 0XY, England, UK
    Curr Opin Cell Biol 25:85-91. 2013
    ..Here we discuss these and other novel findings that have advanced our understanding of the complex process of immunological synapse formation and subsequent induced cell polarity in immune cells...
  9. pmc Hedgehog signaling controls T cell killing at the immunological synapse
    Maike de la Roche
    Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
    Science 342:1247-50. 2013
    ..Thus, Hh signaling plays a role in CTL function, and the immunological synapse may represent a modified cilium. ..
  10. pmc The role of the cytoskeleton at the immunological synapse
    Alex T Ritter
    Cambridge Institute for Medical Research, University of Cambridge Biomedical Campus, Cambridge, UK
    Immunol Rev 256:107-17. 2013
    ..This interface has become known as the immunological synapse, and this review examines some of the roles played by the cytoskeleton at the synapse...
  11. ncbi request reprint Secretory mechanisms in cell-mediated cytotoxicity
    Jane C Stinchcombe
    Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, England
    Annu Rev Cell Dev Biol 23:495-517. 2007
    ..This review focuses on recent advances in our understanding of the molecular basis of polarized secretion from CTLs and the novel mechanism used by these cells to deliver their lethal hit...
  12. pmc A role for Rab7 in the movement of secretory granules in cytotoxic T lymphocytes
    Tiziana Daniele
    Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 0XY, UK
    Traffic 12:902-11. 2011
    ..Together, these results suggest that Rab7 may play a role in secretory lysosome movement toward the centrosome by interacting with RILP to recruit the minus-end motor, dynein...
  13. doi request reprint The cytotoxic T lymphocyte immune synapse at a glance
    Nele M G Dieckmann
    Cambridge Institute for Medical Research, Biomedical Campus, Cambridge CB2 0XY, UK
    J Cell Sci 129:2881-6. 2016
    ....
  14. pmc Munc18-2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T-Lymphocytes
    Nele M G Dieckmann
    Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, United Kingdom
    Traffic 16:1330-41. 2015
    ..These findings support a role for Munc18-2 in chaperoning STX11 to the plasma membrane where the final fusion events involved in secretion occur. ..
  15. pmc Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL
    Misty R Jenkins
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    elife 3:e01310. 2014
    ..DOI: http://dx.doi.org/10.7554/eLife.01310.001. ..
  16. pmc The synapse and cytolytic machinery of cytotoxic T cells
    Misty R Jenkins
    Cambridge Institute for Medical Research, Addenbrooke s, Cambridge, United Kingdom
    Curr Opin Immunol 22:308-13. 2010
    ..This review highlights the important role of avidity in controlling how a T cell kills its target...
  17. pmc Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis
    Fang Zhao
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 36:1003-16. 2012
    ..Hence, SAP and SLAM receptors regulate positive and negative signals required for organizing the T cell:B cell synapse and setting thresholds for cytotoxicity against distinct cellular targets...
  18. pmc Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis
    Jane C Stinchcombe
    Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK
    Curr Biol 25:3239-44. 2015
    ..We propose that this transient centrosome docking without cilia formation is important for CTLs to deliver rapid, repeated polarized secretion directed by the centrosome. ..
  19. pmc Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems
    Jane C Stinchcombe
    Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
    BMC Biol 9:45. 2011
    ....
  20. doi request reprint Origins of the cytolytic synapse
    Maike de la Roche
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK
    Nat Rev Immunol 16:421-32. 2016
    ..Such centrosomal docking at the plasma membrane also occurs during ciliogenesis; indeed, striking similarities exist between the cytolytic synapse and the primary cilium that throw light on the possible origins of immune synapses. ..
  21. pmc Actin depletion initiates events leading to granule secretion at the immunological synapse
    Alex T Ritter
    Cambridge Institute for Medical Research, University of Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK National Institute of Child Health and Disease, NIH, Bethesda, MD 20892, USA
    Immunity 42:864-76. 2015
    ..These data resolve the temporal order of events during synapse maturation in 4D and reveal a critical role for actin depletion in regulating secretion...
  22. pmc The biogenesis of lysosomes and lysosome-related organelles
    J Paul Luzio
    Department of Clinical Biochemistry, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, United Kingdom
    Cold Spring Harb Perspect Biol 6:a016840. 2014
    ..The biogenesis of lysosomes and lysosome-related organelles is discussed, taking into account their dynamic nature and multiple roles. ..
  23. pmc Syntaxin binding mechanism and disease-causing mutations in Munc18-2
    Yvonne Hackmann
    Cambridge Institute for Medical Research, University of Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 110:E4482-91. 2013
    ..Similarly, Munc18-1, expressed in IL-2-activated CTL, is capable of binding Stx11. These findings provide potential explanations for restoration of Munc18-Stx function and cytotoxicity in IL-2-activated cells...
  24. pmc Two patients with Hermansky Pudlak syndrome type 2 and novel mutations in AP3B1
    Matt Wenham
    Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
    Haematologica 95:333-7. 2010
    ..These findings are consistent with CTL granule and platelet dense granule defects, respectively. This report extends the clinical and laboratory description of HPS2...
  25. ncbi request reprint Lytic granules, secretory lysosomes and disease
    Richard Clark
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
    Curr Opin Immunol 15:516-21. 2003
    ..However, studies of this disease reveal differences between the various different types of secretory lysosomes, including lytic granules...
  26. ncbi request reprint Secretory lysosomes
    Emma J Blott
    Sir William Dunn School of Pathology, Oxford University, South Parks Rd, Oxford OX1 3RE, UK
    Nat Rev Mol Cell Biol 3:122-31. 2002
    ..The importance of these organelles is highlighted by several genetic diseases, in which immune function and pigmentation--two processes that normally involve secretory lysosomes--are impaired...
  27. ncbi request reprint Albinism and immunity: what's the link?
    Gillian M Griffiths
    Sir William Dunn School of Pathology, Oxford University, UK
    Curr Mol Med 2:479-83. 2002
    ..These studies reveal that secretory lysosomes use specialised mechanisms of secretion, not found in other cell types, which explains the selective defects in these diseases...
  28. pmc Endocytosing the death sentence
    Gillian M Griffiths
    Sir William Dunn School of Medicine, Oxford OX1 3RE, United Kingdom
    J Cell Biol 160:155-6. 2003
  29. ncbi request reprint The role of the secretory immunological synapse in killing by CD8+ CTL
    Jane C Stinchcombe
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Semin Immunol 15:301-5. 2003
    ..Here we suggest that the CD8(+) cell synapse may not simply be involved in signalling, but may have several important roles in CD8(+) effector function, including targeted delivery, and down-regulation of the cytolytic response...
  30. ncbi request reprint Linking albinism and immunity: the secrets of secretory lysosomes
    Jane Stinchcombe
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
    Science 305:55-9. 2004
    ....
  31. ncbi request reprint CTL secretory lysosomes: biogenesis and secretion of a harmful organelle
    Giovanna Bossi
    Sir William Dunn School of Pathology, University of Oxford, South Park Road, Oxford OX1 3RE, UK
    Semin Immunol 17:87-94. 2005
    ..Here we present an over view of how these key regulators such as AP-3 adaptor protein, RabGGTase enzyme, Rab27a small GTP binding protein, Lyst and Munc13-4 act in a very orchestrated way to deliver the "kiss of the death"...
  32. ncbi request reprint Normal lytic granule secretion by cytotoxic T lymphocytes deficient in BLOC-1, -2 and -3 and myosins Va, VIIa and XV
    Giovanna Bossi
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, UK
    Traffic 6:243-51. 2005
    ..These results reveal differences in the protein machinery required for biogenesis and/or secretion of lysosome-related organelles in CTL and melanocytes...
  33. ncbi request reprint Regulating secretory lysosomes
    Oliver J Holt
    Sir William Dunn School of Pathology, South Parks Rd, Oxford OX1 3RE, UK
    J Biochem 140:7-12. 2006
    ..The different regulatory components seem to vary from one cell type to another, providing a multitude of ways for fine tuning the release of secretory lysosomes...
  34. ncbi request reprint Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation
    Elisabetta Zuccato
    Sir William Dunn School of Pathology, South Parks Rd, Oxford, OX1 3RE, UK
    J Cell Sci 120:191-9. 2007
    ..These studies show that phosphorylation and ubiquitin signals regulate the sorting of FasL to secretory lysosomes by controlling entry into multivesicular bodies...
  35. pmc Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse
    Oliver Holt
    Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford, OX1 3RE, UK
    Traffic 9:446-57. 2008
    ..These results suggest that both Slp1 and Slp2-a may form part of a docking complex, capturing secretory lysosomes at the immunological synapse...