Affiliation: University of Oxford
- Gluenz E, Shaw M, Gull K. Structural asymmetry and discrete nucleic acid subdomains in the Trypanosoma brucei kinetoplast. Mol Microbiol. 2007;64:1529-39 pubmed..We also describe a hitherto unrecognized, intramitochondrial, filamentous structure rich in basic proteins that links the kDNA discs during their segregation and is maintained between them for an extended period of the cell cycle. ..
- Gluenz E, Sharma R, Carrington M, Gull K. Functional characterization of cohesin subunit SCC1 in Trypanosoma brucei and dissection of mutant phenotypes in two life cycle stages. Mol Microbiol. 2008;69:666-80 pubmed publisher..In contrast, cytokinesis was incomplete in bloodstream forms, where cleavage was initiated but cells failed to progress to abscission. Kinetoplast duplication was uninterrupted resulting in cells with multiple kinetoplasts and flagella. ..
- Gluenz E, Povelones M, Englund P, Gull K. The kinetoplast duplication cycle in Trypanosoma brucei is orchestrated by cytoskeleton-mediated cell morphogenesis. Mol Cell Biol. 2011;31:1012-21 pubmed publisher..This new view of the complexities of kinetoplast duplication emphasizes the dependencies between the dynamic remodelling of the cytoskeleton and the inheritance of the mitochondrial genome. ..
- Wheeler R, Gull K, Gluenz E. Detailed interrogation of trypanosome cell biology via differential organelle staining and automated image analysis. BMC Biol. 2012;10:1 pubmed publisher..This presents a technical challenge. Accurate identification and quantitation of the DNA content of these organelles is a central requirement of any automated analysis method...