- Dean J, Robertson Z, Reid V, Wang Q, Hailey H, Moore S, et al. A high frequency of the MTHFR 677C>T polymorphism in Scottish women with epilepsy: possible role in pathogenesis. Seizure. 2008;17:269-75 pubmed..The MTHFR 677C>T polymorphism may be a susceptibility factor for epilepsy, and its higher frequency in women with epilepsy may contribute to the increased risk of malformation in children of women with epilepsy. ..