Arthur M Butt

Summary

Affiliation: University of Portsmouth
Country: UK

Publications

  1. ncbi Regulation of the astrocyte resting membrane potential by cyclic AMP and protein kinase A
    Sally Bolton
    School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom
    Glia 54:316-28. 2006
  2. pmc Inwardly rectifying potassium channels (Kir) in central nervous system glia: a special role for Kir4.1 in glial functions
    Arthur M Butt
    School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael s Building, White Swan Road, Portsmouth PO1 2DT, U K
    J Cell Mol Med 10:33-44. 2006
  3. doi NG2 cells differentiate into astrocytes in cerebellar slices
    Giampaolo Leoni
    Institute of Biology and Biomedical Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK
    Mol Cell Neurosci 42:208-18. 2009
  4. ncbi Decreased Regenerative Capacity of Oligodendrocyte Progenitor Cells (NG2-Glia) in the Ageing Brain: A Vicious Cycle of Synaptic Dysfunction, Myelin Loss and Neuronal Disruption?
    Andrea Rivera
    University of Portsmouth, St Michael s Building Portsmouth PO1 2DT, United Kingdom
    Curr Alzheimer Res 13:413-8. 2016
  5. pmc TASK-1 channels in oligodendrocytes: a role in ischemia mediated disruption
    Virginia Hawkins
    Institute of Biomedical and Biomolecular Science, University of Portsmouth, St Michael s Building, White Swan Rd, Portsmouth, UK
    Neurobiol Dis 55:87-94. 2013
  6. ncbi Neurotransmitter-mediated calcium signalling in oligodendrocyte physiology and pathology
    Arthur M Butt
    School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom
    Glia 54:666-75. 2006
  7. doi ATP: a ubiquitous gliotransmitter integrating neuron-glial networks
    Arthur M Butt
    Institute of Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK
    Semin Cell Dev Biol 22:205-13. 2011
  8. doi Axons and astrocytes release ATP and glutamate to evoke calcium signals in NG2-glia
    Nicola Hamilton
    Institute of Biology and Biomedical Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom
    Glia 58:66-79. 2010
  9. pmc Effects of glutamate receptor activation on NG2-glia in the rat optic nerve
    Nicola Hamilton
    Institute of Biomedical and Biomolecular Science, University of Portsmouth, UK
    J Anat 214:208-18. 2009
  10. doi Relationship between glial potassium regulation and axon excitability: a role for glial Kir4.1 channels
    Virginia Bay
    Institute of Biomedical and Biomolecular Science IBBS, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, United Kingdom
    Glia 60:651-60. 2012

Collaborators

  • Sassan Hafizi
  • Olivier Raineteau
  • A Nishiyama
  • Alexej Verkhratsky
  • Andrea Rivera
  • Nicola Hamilton
  • Sally Bolton
  • Rebekah Wigley
  • Kasum Azim
  • Giampaolo Leoni
  • Kirsty Greenwood
  • Salman Goudarzi
  • Virginia Hawkins
  • Virginia Bay
  • Marcus Rattray
  • Frank Kirchhoff
  • Amanpreet S Kalsi
  • José Julio Rodríguez Arellano
  • Ilaria Vanzulli
  • Ilaria Vanzuli
  • Daniel Fulton
  • Diane R Goddard
  • Greg James
  • Steve Vayro
  • Paul S Hubbard
  • Steven Vayro
  • Jon Robbins
  • Dariuz C Gorecki
  • Niki Hamilton
  • Graham Wilkin
  • Martin Berry
  • Sara L Kirvell

Detail Information

Publications28

  1. ncbi Regulation of the astrocyte resting membrane potential by cyclic AMP and protein kinase A
    Sally Bolton
    School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom
    Glia 54:316-28. 2006
    ..This study provides evidence that the heterogeneous RMP of mature astrocytes is regulated by cAMP and PKA signaling...
  2. pmc Inwardly rectifying potassium channels (Kir) in central nervous system glia: a special role for Kir4.1 in glial functions
    Arthur M Butt
    School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael s Building, White Swan Road, Portsmouth PO1 2DT, U K
    J Cell Mol Med 10:33-44. 2006
    ..1 results in severe hypomyelination. Hence, Kir, and in particular Kir4.1, are key regulators of glial functions, which in turn determine neuronal excitability and axonal conduction...
  3. doi NG2 cells differentiate into astrocytes in cerebellar slices
    Giampaolo Leoni
    Institute of Biology and Biomedical Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK
    Mol Cell Neurosci 42:208-18. 2009
    ..However, NG2-glia did not acquire phenotypic markers of neural stem cells or neurons. The results suggest that NG2-glia are not lineage restricted OPCs and are a potential source of astrocytes in the cerebellum...
  4. ncbi Decreased Regenerative Capacity of Oligodendrocyte Progenitor Cells (NG2-Glia) in the Ageing Brain: A Vicious Cycle of Synaptic Dysfunction, Myelin Loss and Neuronal Disruption?
    Andrea Rivera
    University of Portsmouth, St Michael s Building Portsmouth PO1 2DT, United Kingdom
    Curr Alzheimer Res 13:413-8. 2016
    ..Here, we discuss evidence that deregulation of glutamate neurotransmission in dementia and compromised generation of oligodendrocytes from OPs are key features of myelin loss and associated cognitive decline. ..
  5. pmc TASK-1 channels in oligodendrocytes: a role in ischemia mediated disruption
    Virginia Hawkins
    Institute of Biomedical and Biomolecular Science, University of Portsmouth, St Michael s Building, White Swan Rd, Portsmouth, UK
    Neurobiol Dis 55:87-94. 2013
    ..Since oligodendrocyte damage is a key factor in ischemic episodes, TASK-1 may provide a potential therapeutic target in stroke and white matter disease...
  6. ncbi Neurotransmitter-mediated calcium signalling in oligodendrocyte physiology and pathology
    Arthur M Butt
    School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom
    Glia 54:666-75. 2006
    ..A key issue for future studies is to determine the physiological roles of neurotransmitters in mature oligodendrocytes and NG2-glia (synantocytes)...
  7. doi ATP: a ubiquitous gliotransmitter integrating neuron-glial networks
    Arthur M Butt
    Institute of Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK
    Semin Cell Dev Biol 22:205-13. 2011
    ..Thus, astrocytes are the fulcrum of neuron-glial-vascular networks and purinergic signalling is the primary mechanism by which astrocytes can integrate the functions of these diverse elements...
  8. doi Axons and astrocytes release ATP and glutamate to evoke calcium signals in NG2-glia
    Nicola Hamilton
    Institute of Biology and Biomedical Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom
    Glia 58:66-79. 2010
    ..This study places NG2-glia within a neuron-glial network, and identifies roles for glutamate and ATP in communication with astrocytes as well as axons...
  9. pmc Effects of glutamate receptor activation on NG2-glia in the rat optic nerve
    Nicola Hamilton
    Institute of Biomedical and Biomolecular Science, University of Portsmouth, UK
    J Anat 214:208-18. 2009
    ..The results provide evidence that activation of AMPA-kainate type ionotropic glutamate receptors evoke raised calcium in NG2-glia and induces an injury response in NG2-glia...
  10. doi Relationship between glial potassium regulation and axon excitability: a role for glial Kir4.1 channels
    Virginia Bay
    Institute of Biomedical and Biomolecular Science IBBS, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, United Kingdom
    Glia 60:651-60. 2012
    ..Glial Kir have increasing importance in K(+) clearance at higher levels of axonal activity, helping to maintain the physiological [K(+)](o) ceiling and ensure the fidelity of signaling between the retina and brain...
  11. doi Integration of NG2-glia (synantocytes) into the neuroglial network
    Rebekah Wigley
    Institute for Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK
    Neuron Glia Biol 5:21-8. 2009
    ..The domains of NG2-glia overlap with astrocytes, suggesting they could play a role in integrating non-overlapping astrocyte domains...
  12. pmc Morphological and physiological interactions of NG2-glia with astrocytes and neurons
    Rebekah Wigley
    Institute for Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK
    J Anat 210:661-70. 2007
    ..Moreover, a current concept of NG2-glia considers them to be 'neural stem cells' and an exciting prospect is that neuron-glial signalling may regulate the differentiation capacity of NG2-glia and their response to injury...
  13. doi Intraventricular injection of FGF-2 promotes generation of oligodendrocyte-lineage cells in the postnatal and adult forebrain
    Kasum Azim
    Institute of Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Science, University of Portsmouth, St Michael s Building, Portsmouth, United Kingdom
    Glia 60:1977-90. 2012
    ..This study demonstrates a central role for FGF2 in promoting oligodendrocyte generation in the developing and adult brain...
  14. doi GSK3β negatively regulates oligodendrocyte differentiation and myelination in vivo
    Kasum Azim
    Institute of Biology and Biomedical Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom
    Glia 59:540-53. 2011
    ..This study identifies GSK3β as a profound negative regulator of OL differentiation that contributes to inefficient regeneration of OLs and myelin repair in demyelination...
  15. pmc Immunoablation of cells expressing the NG2 chondroitin sulphate proteoglycan
    Giampaolo Leoni
    Institute of Biology and Biomedical Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK
    J Anat 224:216-27. 2014
    ....
  16. ncbi Cyclic AMP-mediated regulation of the resting membrane potential in myelin-forming oligodendrocytes in the isolated intact rat optic nerve
    Sally Bolton
    School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael s Building, White Swan Road, Portsmouth PO1 2DT, UK
    Exp Neurol 202:36-43. 2006
    ..The results provide evidence of a predominant role for Kir in setting the oligodendroglial RMP and show that cAMP regulates the oligodendroglial RMP, at least partly by a PKA-mediated pathway, possibly by modulating the activity of Kir...
  17. ncbi A Central Role for ATP Signalling in Glial Interactions in the CNS
    Andrea Rivera
    Institute of Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael and 39 s Building, White Swan Road, Portsmouth PO1 2DT, UK
    Curr Drug Targets 17:1829-1833. 2016
    ....
  18. pmc Gas6 Promotes Oligodendrogenesis and Myelination in the Adult Central Nervous System and After Lysolecithin-Induced Demyelination
    Salman Goudarzi
    School of Pharmacy and Biomedical Sciences, Institute of Biomedical and Biomolecular Science, University of Portsmouth, UK
    ASN Neuro 8:. 2016
    ....
  19. doi Mechanisms of ATP- and glutamate-mediated calcium signaling in white matter astrocytes
    Nicola Hamilton
    Department of Physiology, University College London, London, United Kingdom
    Glia 56:734-49. 2008
    ....
  20. pmc Fibroblast growth factor-2 induces astroglial and microglial reactivity in vivo
    Diane R Goddard
    Centre for Neuroscience, King s College London, UK
    J Anat 200:57-67. 2002
    ..The results show that at high CSF titres of FGF-2 induce glial reactivity in vivo and support a role for FGF-2 in the pathology of CNS injury and EAE...
  21. pmc Synantocytes: the fifth element
    Arthur M Butt
    Wolfson Centre for Age Related Diseases, King s College, London, UK
    J Anat 207:695-706. 2005
    ..The general consequences of synantocyte activation are proliferation and phenotypic changes, resulting in glial scar formation, or regeneration of oligodendrocytes, and possibly neurons...
  22. pmc Kir4.1 expression by astrocytes and oligodendrocytes in CNS white matter: a developmental study in the rat optic nerve
    Amanpreet S Kalsi
    Centre for Neuroscience, King s College London, UK
    J Anat 204:475-85. 2004
    ..1 channels are not involved in K(+) regulation. The results support roles for Kir4.1 in both oligodendrocyte differentiation and K(+) regulation by astrocytes...
  23. ncbi Synantocytes: new functions for novel NG2 expressing glia
    Arthur M Butt
    Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College, London SE1 1UL, United Kingdom
    J Neurocytol 31:551-65. 2002
    ..To paraphrase Del Rio Hortega, we propose that synantocytes are the fifth element in the CNS, in addition to neurons, astrocytes, oligodendrocytes and microglia...
  24. ncbi Evidence that perinatal and adult NG2-glia are not conventional oligodendrocyte progenitors and do not depend on axons for their survival
    Kirsty Greenwood
    Centre for Neuroscience Research, GKT School of Biomedical Sciences, King s College, London Bridge, London SE1 1UL, UK
    Mol Cell Neurosci 23:544-58. 2003
    ..We suggest that a population of NG2-glia diverge postnatally into a novel glial type that is functionally and behaviourally distinct from conventional OPCs...
  25. ncbi P2Y and P2X purinoceptor mediated Ca2+ signalling in glial cell pathology in the central nervous system
    Greg James
    Centre for Neuroscience Research, GKT Guy s Campus, King s College London, Hodgkin Building, SE1 1UL, London, UK
    Eur J Pharmacol 447:247-60. 2002
    ..Together, the results implicate ATP as a primary signalling molecule in glial cells and indicate specific roles for P2Y and P2X purinoceptors in glial cell pathology...
  26. ncbi The optic nerve: a model for axon-glial interactions
    Sally Bolton
    Centre for Neuroscience Research, Hodgkin Building, GKT Guy s Campus, King s College, London Bridge, London, SE1 1UL, UK
    J Pharmacol Toxicol Methods 51:221-33. 2005
    ..An overview of the advantages and drawbacks of each technique is given and the application of each to the understanding glial and axonal physiology is briefly discussed...
  27. ncbi Fibroblast growth factor 2 induces loss of adult oligodendrocytes and myelin in vivo
    Arthur M Butt
    Neurorestoration Group, Wolfson Centre for Age Related Disease, Hodgkin Building, GKT Guy s Campus, King s College, London SE1 1UL, UK
    Exp Neurol 192:125-33. 2005
    ..These results demonstrate that raised FGF2 induces demyelination in the adult CNS, and support a role for FGF2 in the pathogenesis of demyelination and regulation of remyelination in MS...
  28. ncbi Fibroblast growth factor 2 mediated disruption of myelin-forming oligodendrocytes in vivo is associated with increased tau immunoreactivity
    Arthur M Butt
    Neurorestoration Group, Wolfson Centre for Age Related Diseases, GKT Guy s Campus, King s College, London SE11UL, UK
    Neurosci Lett 375:28-32. 2005
    ....