Syngenta Central Toxicology Laboratory

Summary

Organization: Syngenta Central Toxicology Laboratory
Country: UK

Top Publications

  1. ncbi Host marking pheromone (HMP) in the Mexican fruit fly Anastrepha ludens
    Andrew J F Edmunds
    Syngenta Crop Protection Muenchwilen AG, Schaffhauserstrasse, CH 4332 Stein
    Chimia (Aarau) 64:37-42. 2010
  2. ncbi The role of the benchmark dose in a regulatory context
    Kim Z Travis
    Syngenta CTL, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK
    Regul Toxicol Pharmacol 43:280-91. 2005
  3. ncbi Absorption, distribution, metabolism and excretion of an inhalation dose of [14C] 4,4'-methylenediphenyl diisocyanate in the male rat
    A Gledhill
    Central Toxicology Laboratory, Alderley Park, UK
    Xenobiotica 35:273-92. 2005
  4. ncbi Impact of cutaneous IL-10 on resident epidermal Langerhans' cells and the development of polarized immune responses
    Marie Cumberbatch
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, United Kingdom
    J Immunol 175:43-50. 2005
  5. ncbi Mapping molecular responses to xenoestrogens through Gene Ontology and pathway analysis of toxicogenomic data
    Richard A Currie
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield SK10 4TJ, UK
    Reprod Toxicol 20:433-40. 2005
  6. ncbi Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate
    Richard A Currie
    Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, United Kingdom
    Toxicol Sci 86:453-69. 2005
  7. ncbi An MS/MS library on an ion-trap instrument for efficient dereplication of natural products. Different fragmentation patterns for [M + H]+ and [M + Na]+ ions
    Andreas Fredenhagen
    Syngenta Crop Protection AG, CPR Analytics, Basel, Switzerland
    J Nat Prod 68:385-91. 2005
  8. ncbi What makes a chemical a respiratory sensitizer?
    Ian Kimber
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Curr Opin Allergy Clin Immunol 5:119-24. 2005
  9. ncbi Synthesis and biological evaluation of himanimide C and unnatural analogues
    Patrice Sellès
    Research Chemistry, Syngenta Crop Protection AG, CH 4002 Basel, Switzerland
    Org Lett 7:605-8. 2005
  10. ncbi Host limits to accurate human growth hormone production in multiple plant systems
    Douglas A Russell
    Agracetus Campus Monsanto, P O Box 620999, Middleton, Wisconsin 53562, USA
    Biotechnol Bioeng 89:775-82. 2005

Detail Information

Publications62

  1. ncbi Host marking pheromone (HMP) in the Mexican fruit fly Anastrepha ludens
    Andrew J F Edmunds
    Syngenta Crop Protection Muenchwilen AG, Schaffhauserstrasse, CH 4332 Stein
    Chimia (Aarau) 64:37-42. 2010
    ..The potential use of such HMP derivatives in a crop protection scenario is briefly discussed...
  2. ncbi The role of the benchmark dose in a regulatory context
    Kim Z Travis
    Syngenta CTL, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK
    Regul Toxicol Pharmacol 43:280-91. 2005
    ..The NOAEL is well suited as a routine simple summary of effects in toxicology studies, whilst the BMD can be a higher tier approach for the interpretation of the most critical studies in a regulatory data package...
  3. ncbi Absorption, distribution, metabolism and excretion of an inhalation dose of [14C] 4,4'-methylenediphenyl diisocyanate in the male rat
    A Gledhill
    Central Toxicology Laboratory, Alderley Park, UK
    Xenobiotica 35:273-92. 2005
    ..No free MDA was detected in any of the biomatrices (urine, faeces, bile) investigated...
  4. ncbi Impact of cutaneous IL-10 on resident epidermal Langerhans' cells and the development of polarized immune responses
    Marie Cumberbatch
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, United Kingdom
    J Immunol 175:43-50. 2005
    ..Thus, TMA-exposed dendritic cells that have been conditioned in vivo with IL-10 (a potent inhibitor of the type 1-polarizing cytokine IL-12) are effective APCs for the development of a Th2-type response...
  5. ncbi Mapping molecular responses to xenoestrogens through Gene Ontology and pathway analysis of toxicogenomic data
    Richard A Currie
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield SK10 4TJ, UK
    Reprod Toxicol 20:433-40. 2005
    ..The utility of this in mechanistic toxicology will be illustrated using examples in which GO mapping of toxicogenomic data has provided novel insights into the molecular mechanisms induced by exposure to xenoestrogens...
  6. ncbi Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate
    Richard A Currie
    Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, United Kingdom
    Toxicol Sci 86:453-69. 2005
    ....
  7. ncbi An MS/MS library on an ion-trap instrument for efficient dereplication of natural products. Different fragmentation patterns for [M + H]+ and [M + Na]+ ions
    Andreas Fredenhagen
    Syngenta Crop Protection AG, CPR Analytics, Basel, Switzerland
    J Nat Prod 68:385-91. 2005
    ..The cleavage of the ester bond is the preferred mechanism in the positive ion mode, whereas two different pathways-one showing a rare retro-Michael-addition-are observed in the negative ion mode...
  8. ncbi What makes a chemical a respiratory sensitizer?
    Ian Kimber
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Curr Opin Allergy Clin Immunol 5:119-24. 2005
    ..In this article we consider the characteristics that are associated with chemical respiratory allergens, and that may be essential for effective sensitization of the respiratory tract...
  9. ncbi Synthesis and biological evaluation of himanimide C and unnatural analogues
    Patrice Sellès
    Research Chemistry, Syngenta Crop Protection AG, CH 4002 Basel, Switzerland
    Org Lett 7:605-8. 2005
    ..The flexibility of the synthesis is exemplified by the preparation of new unnatural himanimide analogues in order to investigate the fungicidal potency of this new family. [structure: see text]..
  10. ncbi Host limits to accurate human growth hormone production in multiple plant systems
    Douglas A Russell
    Agracetus Campus Monsanto, P O Box 620999, Middleton, Wisconsin 53562, USA
    Biotechnol Bioeng 89:775-82. 2005
    ..Together, the data indicate the dependence of recombinant protein accumulation on posttranslational processes in different host systems...
  11. ncbi Review of the genotoxicity of 4-chloro-2-methylphenoxyacetic acid
    Barry Elliott
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield SK10 4TJ, UK
    Mutagenesis 20:3-13. 2005
    ..This is consistent with its lack of carcinogenicity in rats and mice...
  12. ncbi Developmental changes of thyroid hormones in the fathead minnow, Pimephales promelas
    Helen M Crane
    School of Biological and Chemical Sciences, Hatherly Laboratories, Prince of Wales Road, University of Exeter, EX4 4PS, UK
    Gen Comp Endocrinol 139:55-60. 2004
    ..These data suggest a prominent role for thyroid hormones in early developmental processes when we predict that the ecotoxicological effects of thyroid disrupters will be most significant...
  13. ncbi An efficient mannose selection protocol for tomato that has no adverse effect on the ploidy level of transgenic plants
    Marina Sigareva
    Syngenta Biotechnology, 3054 Cornwallis Road, Research Triangle Park, NC 27709 2257, USA
    Plant Cell Rep 23:236-45. 2004
    ..Results described in this study demonstrate that, although transformation frequencies for leaf tissue are still lower under current protocols, the high percentage of diploids obtained make leaf tissue an attractive transformation target...
  14. pmc Natural variability and the influence of concurrent control values on the detection and interpretation of low-dose or weak endocrine toxicities
    John Ashby
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, United Kingdom
    Environ Health Perspect 112:847-53. 2004
    ..Our recommendations on experimental design are also presented, with a view to ending the current impasse on the reality, or otherwise, of low-dose or weak endocrine toxicities...
  15. ncbi Historical perspective of the cancer bioassay
    Timothy Pastoor
    Syngenta Crop Protection Inc, Greensboro, NC, 27419, USA
    Scand J Work Environ Health 31:129-40; discussion 119-22. 2005
    ....
  16. ncbi Characterization of the diffusion of non-electrolytes across plant cuticles: properties of the lipophilic pathway
    Anke Buchholz
    Syngenta Crop Protection AG, Research Biology, CH 4332 Stein, Switzerland
    J Exp Bot 57:2501-13. 2006
    ..This approach also explains the mode of action and the intrinsic activity of plasticizers...
  17. ncbi Skin sensitization potency of methyl methacrylate in the local lymph node assay: comparisons with guinea-pig data and human experience
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK1 4TJ, UK
    Contact Dermatitis 55:140-7. 2006
    ..Results of LLNA studies have been interpreted in the context of historical clinical data on occupational allergic contact dermatitis associated with exposure to MMA...
  18. doi The behavior of isopyrazam in aquatic ecosystems: implementation of a tiered investigation
    Laurence H Hand
    Syngenta, Jealott s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom
    Environ Toxicol Chem 29:2702-12. 2010
    ....
  19. doi New capabilities for Mycosphaerella graminicola research
    Judith Bowler
    Syngenta, Jealott s Hill International Research Centre, Bracknell, Berkshire, UK
    Mol Plant Pathol 11:691-704. 2010
    ..The collective use of these tools will permit further advancements in our knowledge of the biology and pathogenicity of this important plant pathogen...
  20. pmc Environmental risk assessments for transgenic crops producing output trait enzymes
    Alan Raybould
    Syngenta, Jealott s Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, UK
    Transgenic Res 19:595-609. 2010
    ....
  21. doi Beyond physical properties--application of Abraham descriptors and LFER analysis in agrochemical research
    Eric D Clarke
    Syngenta, International Research Centre, Jealott s Hill, Bracknell, Berkshire, RG42 6EY, UK
    Bioorg Med Chem 17:4153-9. 2009
    ..Experimental descriptors were used to derive linear free energy relationships for soil binding and root uptake, to provide insights to these processes...
  22. pmc Mechanism of inhibition defines CETP activity: a mathematical model for CETP in vitro
    Laura K Potter
    Scientific Computing and Mathematical Modeling, GlaxoSmithKline, King of Prussia, PA, USA
    J Lipid Res 50:2222-34. 2009
    ....
  23. doi Assessment of the toxicological interaction of sertraline with cholinesterase inhibiting insecticides in aquatic insects using the black fly, Simulium vittatum IS-7
    Jay P Overmyer
    Department of Entomology, University of Georgia, 413 Biological Sciences Building, Athens, Georgia 30602, USA
    Environ Toxicol 25:28-37. 2010
    ..These results indicate that sertraline and the insecticides are likely eliciting toxicity at separate neuronal pathways since no interaction was observed...
  24. doi Alkyne chemistry in crop protection
    Clemens Lamberth
    Syngenta Crop Protection AG, Crop Protection Research, Chemistry, Schaffhauserstr 101, CH 4332 Stein, Switzerland
    Bioorg Med Chem 17:4047-63. 2009
    ..Also the importance of alkynes as intermediates in the preparation of agrochemicals is demonstrated...
  25. pmc The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D
    Patrick J Crowley
    Syngenta, Jealott s Hill International Research Centre, Bracknell, Berkshire RG426EY, UK
    Bioorg Med Chem 16:10345-55. 2008
    ....
  26. ncbi Identification of an alginate-based formulation of paraquat to reduce the exposure of the herbicide following oral ingestion
    J R Heylings
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, United Kingdom
    Toxicology 241:1-10. 2007
    ..However, we anticipate that this alginate technology in Gramoxone INTEON could have significant benefit in reducing human mortalities associated with the herbicide...
  27. ncbi Ring-modified analogues and molecular dynamics studies to probe the requirements for fungicidal activities of malayamycin A and its N-nucleoside variants
    Olivier Loiseleur
    Syngenta, Crop Protection Research, Schwarzwaldallee 215, CH 4002 Basel, Switzerland
    J Org Chem 72:6353-63. 2007
    ..Molecular dynamics studies on malayamycin A and analogues were performed to highlight the importance of properly orientating the urea and methyl ether groups...
  28. pmc QTL mapping of agronomic traits in tef [Eragrostis tef (Zucc) Trotter]
    Ju Kyung Yu
    Department of Plant Breeding and Genetics, Cornell University, Ithaca, NY 14853, USA
    BMC Plant Biol 7:30. 2007
    ..The goal of this study was to identify agronomically important quantitative trait loci (QTL) using recombinant inbred lines (RIL) derived from an inter-specific cross between E. tef and E. pilosa (30-5)...
  29. ncbi Real-time quantitative PCR assays for quantification of L1781 ACCase inhibitor resistance allele in leaf and seed pools of Lolium populations
    Shiv S Kaundun
    Syngenta, Jealott s Hill International Research Centre, Bracknell, Berkshire, UK
    Pest Manag Sci 62:1082-91. 2006
    ..Therefore, it offers the opportunity to tackle resistance at its very onset, potentially avoiding implementation of complicated and often costly weed management practices...
  30. ncbi Modern agrochemical research: a missed opportunity for drug discovery?
    John Delaney
    Syngenta, Jealott s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
    Drug Discov Today 11:839-45. 2006
    ....
  31. ncbi The validation of in vitro methods for skin irritation
    Philip A Botham
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield SK10 4TJ, UK
    Toxicol Lett 149:387-90. 2004
    ..In 2003, ECVAM concluded that they could proceed to a full validation study. This will be conducted in two phases and is scheduled for completion early in 2005...
  32. ncbi Classification of contact allergens according to potency: proposals
    I Kimber
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Food Chem Toxicol 41:1799-809. 2003
    ..Included here are detailed and specific recommendations for how best the results of the three test methods considered can be used for the categorisation of chemical allergens as a function of skin sensitisation potency...
  33. pmc Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin-1beta
    Marie Cumberbatch
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, UK
    Immunology 105:466-77. 2002
    ....
  34. ncbi A draft sequence of the rice genome (Oryza sativa L. ssp. japonica)
    Stephen A Goff
    Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, CA 92121, USA
    Science 296:92-100. 2002
    ..Assignment of candidate rice orthologs to Arabidopsis genes is possible in many cases. The rice genome sequence provides a foundation for the improvement of cereals, our most important crops...
  35. ncbi Allergic contact dermatitis
    Ian Kimber
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK
    Int Immunopharmacol 2:201-11. 2002
    ..This article seeks to consider skin sensitization and ACD in holistic fashion, bridging experimental observations with clinical disease and basic mechanisms with practical toxicology...
  36. ncbi Partitioning, bioavailability, and toxicity of the pyrethroid insecticide cypermethrin in sediments
    Steve J Maund
    Syngenta, Jealott s Hill International Research Centre, Bracknell, Berkshire, United Kingdom
    Environ Toxicol Chem 21:9-15. 2002
    ....
  37. ncbi Expectations for transgenic rodent cancer bioassay models
    J Ashby
    Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, United Kingdom
    Toxicol Pathol 29:177-82. 2001
    ..In the absence of such initiatives the increasing number of new bioassay models will come to exist along side of the standard 2-species bioassay, and this may potentially lead to confusion regarding the true future role of these assays...
  38. ncbi Outcrossing and recombination in the lichenized fungus Letharia
    S Kroken
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Fungal Genet Biol 34:83-92. 2001
    ..Therefore, it appears that even in the sorediate species, rare sexual reproduction results in recombination...
  39. ncbi The toxicity of styrene to the nasal epithelium of mice and rats: studies on the mode of action and relevance to humans
    T Green
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, SK10 4TJ, Cheshire, UK
    Chem Biol Interact 137:185-202. 2001
    ....
  40. ncbi Identification of a 2,6-dichloroisonicotinic-acid-sensitive protein kinase from tobacco by affinity chromatography on benzothiadiazole-sepharose and NIM-metal chelate adsorbent
    C Pillonel
    Novartis Crop Protection Ltd, CH 4002 Basel, Switzerland
    Pest Manag Sci 57:676-82. 2001
    ..Comparison between BBPK cell-free inhibition and in vivo PR-1 induction revealed that BBPK could be the target site of INA...
  41. ncbi Principal components analysis of protein structure ensembles calculated using NMR data
    P W Howe
    Analytical Sciences, Syngenta, Jealott s Hill International Research Centre, Bracknell, Berkshire, UK
    J Biomol NMR 20:61-70. 2001
    ..The PCA analysis also correctly identifies the structural differences between the two conformations...
  42. ncbi Genes controlling expression of defense responses in Arabidopsis--2001 status
    J Glazebrook
    Torrey Mesa Research Institute, 3115 Merryfield Row, San Diego, CA 92121, USA
    Curr Opin Plant Biol 4:301-8. 2001
    ..Genes required for jasmonic-acid-dependent signaling and for induced systemic resistance have also been identified...
  43. ncbi MRI studies of the neurotoxic effects of L-2-chloropropionic acid on rat brain
    R E Williams
    Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
    Magn Reson Imaging 19:133-42. 2001
    ..The occurrence of T(2)WI hyperintensity in the forebrain lead us to discover a new lesion in the habenular nucleus...
  44. ncbi Application of genomics to the definition of the molecular basis for toxicity
    W D Pennie
    Syngenta Central Toxicology Laboratory, Macclesfield, SK10 4TJ, Cheshire, UK
    Toxicol Lett 120:353-8. 2001
    ....
  45. ncbi Testing for endocrine disruption post-EDSTAC: extrapolation of low dose rodent effects to humans
    J Ashby
    Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, Macclesfield, UK
    Toxicol Lett 120:233-42. 2001
    ..Only when these factors are generally accepted and well studied will it be possible to relate effects seen in rodents to humans...
  46. ncbi A comparison of rate-response toxicity tests with Aphidius rhopalosiphi (Hymenoptera: Aphidiidae) using glass, leaves and whole plants as substrate
    C Grimm
    Chemosphere 48:581-9. 2002
    ..The LR50 values were 7.8-340 times higher on whole plants than on glass plates. Because of the variability of this factor, a numerical safety factor cannot be used to substitute extended laboratory testing for regulatory purposes...
  47. pmc Proteomic survey of metabolic pathways in rice
    Antonius Koller
    Protein and Metabolite Dynamics Department, Torrey Mesa Research Institute, 3115 Merryfield Row, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 99:11969-74. 2002
    ..In addition, several previously characterized allergenic proteins were identified in the seed sample, indicating the potential of proteomic approaches to survey food samples with regard to the occurrence of allergens...
  48. ncbi Rapid two-dimensional analysis of proteins by ultra-thin layer gel electrophoresis
    Andras Guttman
    Torrey Mesa Research Institute, La Jolla, CA 92121, USA
    Proteomics 2:469-74. 2002
    ..The advantage of the technology discussed over existing techniques is its simplicity, speed and good detection sensitivity...
  49. ncbi Designation of substances as skin sensitizing chemicals: a commentary
    I Kimber
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclestield, Cheshire, UK
    Hum Exp Toxicol 22:439-43. 2003
    ..This new scheme we believe provides a realistic framework within which informed decisions can be reached about likely skin sensitizing activity based upon judicious consideration of clinical and experimental information...
  50. pmc The mode of action of the Bacillus thuringiensis vegetative insecticidal protein Vip3A differs from that of Cry1Ab delta-endotoxin
    Mi Kyong Lee
    Insect Resistance, Syngenta Biotechnology, Inc, Research Triangle Park, North Carolina 27709 2257, USA
    Appl Environ Microbiol 69:4648-57. 2003
    ..The mode of action of Vip3A supports its use as a novel insecticidal agent...
  51. ncbi Determination of antifungal proteins in soil by liquid chromatography
    Elek Bolygo
    Jealott s Hill International Research Centre, Syngenta, RG42 6EY, Bracknell, Berkshire, UK
    Anal Bioanal Chem 376:701-5. 2003
    ..The antifungal proteins were found to be stable in soil extract tested up to 9 days when stored at 4 degrees C...
  52. pmc IL-1beta-induced Langerhans' cell migration and TNF-alpha production in human skin: regulation by lactoferrin
    M Cumberbatch
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK
    Clin Exp Immunol 132:352-9. 2003
    ..Topical treatment with LF compromises both these responses. These data suggest that topical LF may potentially represent a novel therapeutic in the treatment of skin inflammation where TNF-alpha is an important mediator...
  53. ncbi The leading role and responsibility of the international scientific community in test development
    John Ashby
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, SK10 4TJ, Cheshire, UK
    Toxicol Lett 140:37-42. 2003
    ..This article describes the particular scientific issues associated with the validation of these two assays and alerts to the continuing need to consider new assay protocols as they become available...
  54. pmc Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae
    Michael P Washburn
    Proteomics, Torrey Mesa Research Institute, 3115 Merryfield Row, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:3107-12. 2003
    ..g., SPT, COPI, and ribosome) was posttranscriptionally controlled. The coupling of the methods described provided insight into the biology of S. cerevisiae and a clustering strategy by which future studies should be based...
  55. ncbi Sex steroids, ANGELS and osteoporosis
    Jonathan G Moggs
    Syngenta CTL, Alderley Park, Cheshire, United Kingdom
    Bioessays 25:195-9. 2003
    ..This compound acts via a novel extranuclear sex steroid receptor signaling mechanism that has important implications for nuclear receptor biology and human health...
  56. ncbi Chemical allergy: considerations for the practical application of cytokine profiling
    Rebecca J Dearman
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, United Kingdom
    Toxicol Sci 71:137-45. 2003
    ..The purpose of this brief review article is to consider the approaches available and to highlight key procedural issues...
  57. ncbi Assessing the health risks following environmental exposure to hexachlorobutadiene
    Trevor Green
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Toxicol Lett 138:63-73. 2003
    ..41 ppm HCBD. This is in contrast to the figure of 0.6 ppb which is obtained when it is assumed that the risk is associated with the internal dose of HCBD itself rather than beta-lyase metabolites...
  58. ncbi Assessment of glycosylation-dependent cell adhesion molecule 1 as a correlate of allergen-stimulated lymph node activation
    Catherine J Betts
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Toxicology 185:103-17. 2003
    ....
  59. ncbi Chemical respiratory allergy: role of IgE antibody and relevance of route of exposure
    Ian Kimber
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    Toxicology 181:311-5. 2002
    ..The significance of IgE antibody and dermal exposure in the context of occupational respiratory allergy to chemicals is discussed...
  60. pmc A high-throughput Arabidopsis reverse genetics system
    Allen Sessions
    Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, California 92121, USA
    Plant Cell 14:2985-94. 2002
    ..Predicted insertions were confirmed in 257 of 340 lines tested (76%). This resource has been named SAIL (Syngenta Arabidopsis Insertion Library) and is available to the scientific community at www.tmri.org...
  61. ncbi Effect of intestinal microflora on the urinary metabolic profile of rats: a (1)H-nuclear magnetic resonance spectroscopy study
    R E Williams
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, SK10 4TJ, UK
    Xenobiotica 32:783-94. 2002
    ..5. These results demonstrate that the observed difference in HA/m-HPPA excretion is due to differences in the intestinal microflora...
  62. ncbi Cytokine fingerprinting and hazard assessment of chemical respiratory allergy
    R J Dearman
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK
    J Appl Toxicol 21:153-63. 2001
    ..In this article the immunobiological basis for cytokine fingerprinting is considered and the development, evaluation and practical application of the assay are reviewed...