Affiliation: St George's Hospital Medical School
- Morgan R, Sohal J, Paleja M, Pettengell R. Pbx genes are required in Xenopus lens development. Int J Dev Biol. 2004;48:623-7 pubmed..Here we show that the Pbx transcription factor plays a crucial role in this process, as it is required for FGF8 expression in the neural plate and is thus part of the complex hierarchy of genes involved in lens induction. ..
- Morgan R, El Kadi A, Theokli C. Flamingo, a cadherin-type receptor involved in the Drosophila planar polarity pathway, can block signaling via the canonical wnt pathway in Xenopus laevis. Int J Dev Biol. 2003;47:245-52 pubmed..We show that ectopic expression of the murine Flamingo gene can prevent the wnt mediated posteriorisation of the neural plate by interfering with the canonical wnt signalling pathway. ..
- Morgan R, Nalliah A, Morsi El Kadi A. FLASH, a component of the FAS-CAPSASE8 apoptotic pathway, is directly regulated by Hoxb4 in the notochord. Dev Biol. 2004;265:105-12 pubmed..FLASH is a component of the FAS-CAPSASE8 apoptotic pathway, and blocking its activity, or that of Hoxb4, prevents apoptosis in the notochord...