Affiliation: Institute of Cancer Research
- Ashworth A. A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J Clin Oncol. 2008;26:3785-90 pubmed publisher..This provides the basis for a novel synthetic lethal approach to cancer therapy. ..
- Rovillain E, Mansfield L, Lord C, Ashworth A, Jat P. An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence. BMC Genomics. 2011;12:355 pubmed publisher..Future studies will focus on determining on how many of the other primary hits also have a casual role in senescence and what is the mechanism of action. ..
- Panchal H, Wansbury O, Parry S, Ashworth A, Howard B. Neuregulin3 alters cell fate in the epidermis and mammary gland. BMC Dev Biol. 2007;7:105 pubmed..The results we describe provide significant insight into how growth factors, such as Nrg3, regulate epidermal homeostasis by influencing the balance between stem cell renewal, lineage selection and differentiation. ..
- Ashworth A. Drug resistance caused by reversion mutation. Cancer Res. 2008;68:10021-3 pubmed publisher..Furthermore, a similar mechanism seems to be associated with carboplatin resistance in some BRCA2 mutation carriers with ovarian cancer. ..