P K Jeffery

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi request reprint Comparison of the structural and inflammatory features of COPD and asthma. Giles F. Filley Lecture
    P K Jeffery
    Imperial College School of Medicine at the Royal Brompton Hospital, London, UK
    Chest 117:251S-60S. 2000
  2. ncbi request reprint Exacerbations of Bronchitis: bronchial eosinophilia and gene expression for interleukin-4, interleukin-5, and eosinophil chemoattractants
    J Zhu
    Department of Gene Therapy, National Heart and Lung Institute, Imperial College School of Medicine at the Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 164:109-16. 2001
  3. doi request reprint Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-κB and EGFR pathways
    C A Hewson
    Dept of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London, W2 1PG, UK
    Eur Respir J 36:1425-35. 2010
  4. doi request reprint Montelukast and bronchial inflammation in asthma: a randomised, double-blind placebo-controlled trial
    C F Ramsay
    Department of Respiratory Medicine, Royal London Hospital, London, UK
    Respir Med 103:995-1003. 2009
  5. ncbi request reprint Biopsy markers of airway inflammation and remodelling
    P K Jeffery
    Imperial College School of Medicine at the Royal Brompton Hospital, London, UK
    Respir Med 94:S9-15. 2000
  6. ncbi request reprint Bronchial mucosal dendritic cells in smokers and ex-smokers with COPD: an electron microscopic study
    A V Rogers
    Lung Pathology Unit, Department of Gene Therapy, Imperial College London, London, UK
    Thorax 63:108-14. 2008
  7. ncbi request reprint Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis
    E Gamble
    Department of Respiratory Medicine, London Chest Hospital, Bonner Road, London, UK
    Eur Respir J 30:467-71. 2007
  8. pmc Can HRCT be used as a marker of airway remodelling in children with difficult asthma?
    S Saglani
    Respiratory Paediatrics, Royal Brompton Hospital, London, UK
    Respir Res 7:46. 2006
  9. pmc Airway inflammation in children with difficult asthma: relationships with airflow limitation and persistent symptoms
    D N R Payne
    Department of Paediatrics, Imperial College London at the Royal Brompton Hospital, UK
    Thorax 59:862-9. 2004
  10. ncbi request reprint Safety of research bronchoscopy, biopsy and bronchoalveolar lavage in asthma
    W J Elston
    Dept of Respiratory Medicine, London Chest Hospital, Bonner Road, London, E2 9JX, UK
    Eur Respir J 24:375-7. 2004

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Comparison of the structural and inflammatory features of COPD and asthma. Giles F. Filley Lecture
    P K Jeffery
    Imperial College School of Medicine at the Royal Brompton Hospital, London, UK
    Chest 117:251S-60S. 2000
    ..While differences between COPD and asthma have been highlighted, new data are emerging that indicate there may also be similarities...
  2. ncbi request reprint Exacerbations of Bronchitis: bronchial eosinophilia and gene expression for interleukin-4, interleukin-5, and eosinophil chemoattractants
    J Zhu
    Department of Gene Therapy, National Heart and Lung Institute, Imperial College School of Medicine at the Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 164:109-16. 2001
    ....
  3. doi request reprint Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-κB and EGFR pathways
    C A Hewson
    Dept of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London, W2 1PG, UK
    Eur Respir J 36:1425-35. 2010
    ..Revealing the complex serial signalling cascade involved identifies targets for development of pharmacologic intervention to treat mucus hypersecretion in RV-induced illness...
  4. doi request reprint Montelukast and bronchial inflammation in asthma: a randomised, double-blind placebo-controlled trial
    C F Ramsay
    Department of Respiratory Medicine, Royal London Hospital, London, UK
    Respir Med 103:995-1003. 2009
    ..Examination of bronchoalveolar lavage, induced sputum, and peripheral blood indicate that cysteinyl leukotriene receptor blockers decrease inflammatory cells in asthma but these do not examine airway tissue per se...
  5. ncbi request reprint Biopsy markers of airway inflammation and remodelling
    P K Jeffery
    Imperial College School of Medicine at the Royal Brompton Hospital, London, UK
    Respir Med 94:S9-15. 2000
    ..Reliable markers of remodelling need to be identified to improve our ability to evaluate chronic asthma therapy...
  6. ncbi request reprint Bronchial mucosal dendritic cells in smokers and ex-smokers with COPD: an electron microscopic study
    A V Rogers
    Lung Pathology Unit, Department of Gene Therapy, Imperial College London, London, UK
    Thorax 63:108-14. 2008
    ..The present study compares DC numbers in smokers and ex-smokers with COPD...
  7. ncbi request reprint Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis
    E Gamble
    Department of Respiratory Medicine, London Chest Hospital, Bonner Road, London, UK
    Eur Respir J 30:467-71. 2007
    ..It is concluded that, in established chronic obstructive pulmonary disease, the bronchial mucosal inflammatory cell infiltrate is similar in ex-smokers and those that continue to smoke...
  8. pmc Can HRCT be used as a marker of airway remodelling in children with difficult asthma?
    S Saglani
    Respiratory Paediatrics, Royal Brompton Hospital, London, UK
    Respir Res 7:46. 2006
    ..A similar relationship in children with difficult asthma (DA), in whom RBM thickening is a known feature, may allow the use of HRCT as a non-invasive marker of airway remodelling. We evaluated this relationship in children with DA...
  9. pmc Airway inflammation in children with difficult asthma: relationships with airflow limitation and persistent symptoms
    D N R Payne
    Department of Paediatrics, Imperial College London at the Royal Brompton Hospital, UK
    Thorax 59:862-9. 2004
    ..The effective management and development of new treatments for children with difficult asthma requires investigation of the underlying airway pathology and its relationships with persistent symptoms and airflow limitation...
  10. ncbi request reprint Safety of research bronchoscopy, biopsy and bronchoalveolar lavage in asthma
    W J Elston
    Dept of Respiratory Medicine, London Chest Hospital, Bonner Road, London, E2 9JX, UK
    Eur Respir J 24:375-7. 2004
    ..Most of the complications were seen where bronchoalveolar lavage and endobronchial biopsy were both performed, suggesting that bronchoalveolar lavage accounts for most of the adverse events...
  11. ncbi request reprint Effects of salmeterol on mucosal inflammation in asthma: a placebo-controlled study
    P K Jeffery
    Lung Pathology Unit, Dept of Gene Therapy, National Heart and Lung Institute, Imperial College, Royal Brompton Hospital, London, UK
    Eur Respir J 20:1378-85. 2002
    ..In conclusion, a novel antineutrophilic effect of the inhaled long-acting beta2-adrenergic receptor agonist, salmeterol, in mild asthma is reported...
  12. pmc Effects of fluticasone propionate on inflammatory cells in COPD: an ultrastructural examination of endobronchial biopsy tissue
    M J Gizycki
    Lung Pathology Unit, Imperial College School of Medicine at the Royal Brompton Hospital, London, UK London Chest Hospital, London, UK
    Thorax 57:799-803. 2002
    ..Inhaled corticosteroids (ICS) markedly reduce bronchial mucosal inflammation in asthma but whether they have an anti-inflammatory effect in airway tissue in chronic obstructive pulmonary disease (COPD) is unknown...
  13. ncbi request reprint Variation of CD8+ T-lymphocytes around the bronchial internal perimeter in chronic bronchitis
    E Gamble
    Lung Pathology, Dept of Gene Therapy, Imperial College London at the Royal Brompton Hospital, London, UK
    Eur Respir J 22:992-5. 2003
    ..In order to achieve a representative count and to maximise statistical power to detect differences between study populations, subepithelial tissue including a minimum of 5 mm of reticular basement membrane length should be examined...
  14. ncbi request reprint Variability of bronchial inflammation in chronic obstructive pulmonary disease: implications for study design
    E Gamble
    Lung Pathology, Imperial College at the Royal Brompton Hospital, London, UK
    Eur Respir J 27:293-9. 2006
    ..Therefore, biopsies from more than one airway generation should be examined in order to maximise statistical power to detect a difference between study groups...
  15. ncbi request reprint Ultrastructure of the reticular basement membrane in asthmatic adults, children and infants
    S Saglani
    Lung Pathology, Dept of Gene Therapy, Imperial College at the Royal Brompton Hospital, London, UK
    Eur Respir J 28:505-12. 2006
    ..49) versus 1.18 (0.31-2.6)). The ratio of fibril to matrix in the thickened reticular basement membrane of asthmatics is normal, and, contrary to what is expected in fibrosis, the fibrils do not resemble those of interstitial collagen...
  16. ncbi request reprint Intravenously administered oligonucleotides can be delivered to conducting airway epithelium via the bronchial circulation
    E Holder
    Department of Gene Therapy, Faculty of Medicine, Imperial College, Manrisa Road, London, UK
    Gene Ther 13:1628-38. 2006
    ..ODNs may be relevant to CF in a variety of ways and these data suggest one way towards implementing their use...
  17. ncbi request reprint Interleukin-4 and interleukin-5 gene expression and inflammation in the mucus-secreting glands and subepithelial tissue of smokers with chronic bronchitis. Lack of relationship with CD8(+) cells
    J Zhu
    Department of Gene Therapy, Imperial College School of Medicine, London, United Kingdom
    Am J Respir Crit Care Med 164:2220-8. 2001
    ....
  18. ncbi request reprint Lymphocytes, chronic bronchitis and chronic obstructive pulmonary disease
    P K Jeffery
    Lung Pathology Unit (Department of Gene Therapy, Imperial College School of Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Novartis Found Symp 234:149-61; discussion 161-8. 2001
    ..Viruses may modulate these changes in distinct lymphocyte functional phenotypes. The relevance and importance of CD4/CD8 T lymphocyte ratio to the development of COPD is discussed...
  19. ncbi request reprint A role for the beta2 integrin CD11b in mediating experimental lung injury in mice
    J M Miotla
    Department of Lung Pathology, Royal Brompton National Heart and Lung Institute, London, United Kingdom
    Am J Respir Cell Mol Biol 14:363-73. 1996
    ....