Eric W F W Alton
Affiliation: Imperial College
Paul Smith M, Pytel K, Gélinas J, McIntosh J, Pringle I, Davies L, et al
. The murine lung as a factory to produce secreted intrapulmonary and circulatory proteins. Gene Ther. 2018;: pubmed publisher
..These data broaden the use of this vector platform for a large range of disease indications. ..
Alton E, Armstrong D, Ashby D, Bayfield K, Bilton D, Bloomfield E, et al
. Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial. Lancet Respir Med. 2015;3:684-691 pubmed publisher
..Medical Research Council/National Institute for Health Research Efficacy and Mechanism Evaluation Programme. ..
Leoni G, Wasowicz M, Chan M, Meng C, Farley R, Brody S, et al
. Ex Vivo and In Vivo Lentivirus-Mediated Transduction of Airway Epithelial Progenitor Cells. Curr Gene Ther. 2015;15:581-90 pubmed
..These results indicate that our lentiviral vector can transduce progenitor basal cells in vivo, although transduction required denudation of the surface epithelium prior to vector administration. ..