C Parr

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint Hepatocyte growth factor activation inhibitors - therapeutic potential in cancer
    Christian Parr
    Cardiff University, UK
    Anticancer Agents Med Chem 10:47-57. 2010
  2. ncbi request reprint The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer
    C Parr
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff CF4 4XN, UK
    Int J Mol Med 14:779-86. 2004
  3. ncbi request reprint Placenta growth factor is over-expressed and has prognostic value in human breast cancer
    Christian Parr
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Eur J Cancer 41:2819-27. 2005
  4. ncbi request reprint The hepatocyte growth factor regulatory factors in human breast cancer
    Christian Parr
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    Clin Cancer Res 10:202-11. 2004
  5. ncbi request reprint Hepatocyte growth factor activation inhibitors (HAI-1 and HAI-2) regulate HGF-induced invasion of human breast cancer cells
    Christian Parr
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, UK
    Int J Cancer 119:1176-83. 2006
  6. ncbi request reprint Quantitative analysis of lymphangiogenic markers in human colorectal cancer
    C Parr
    Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Int J Oncol 23:533-9. 2003
  7. ncbi request reprint Reduced vascular endothelial growth inhibitor (VEGI) expression is associated with poor prognosis in breast cancer patients
    Christian Parr
    Department of Surgery, Wales College of Medicine, Metastasis and Angiogenesis Research Group, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Angiogenesis 9:73-81. 2006
  8. ncbi request reprint Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients
    Christian Parr
    Metastasis and Angiogenesis Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Clin Cancer Res 13:3568-76. 2007
  9. ncbi request reprint Hepatocyte growth factor activators, inhibitors and antagonists and their implication in cancer intervention
    C Parr
    University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Histol Histopathol 16:251-68. 2001
  10. ncbi request reprint Nk4, a new HGF/SF variant, is an antagonist to the influence of HGF/SF on the motility and invasion of colon cancer cells
    C Parr
    University Department of Surgery, University of Wales College of Medicine, Cardiff, UK
    Int J Cancer 85:563-70. 2000

Detail Information

Publications30

  1. ncbi request reprint Hepatocyte growth factor activation inhibitors - therapeutic potential in cancer
    Christian Parr
    Cardiff University, UK
    Anticancer Agents Med Chem 10:47-57. 2010
    ..Therefore, these HGF activation inhibitors may have a direct bearing on cancer invasion and metastasis. This review examines the accumulating evidence on the emerging role and therapeutic potential of HAI-1 and HAI-2 in cancer...
  2. ncbi request reprint The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer
    C Parr
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff CF4 4XN, UK
    Int J Mol Med 14:779-86. 2004
    ..These results support the notion that suppression of Notch-1 activity may represent a novel therapeutic strategy...
  3. ncbi request reprint Placenta growth factor is over-expressed and has prognostic value in human breast cancer
    Christian Parr
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Eur J Cancer 41:2819-27. 2005
    ..017) with recurrence, metastasis and patient mortality. Our study has shown that PlGF is over-expressed in breast cancer tissues and correlates with patient prognosis, and is likely to play a major role in the pathogenesis of tumours...
  4. ncbi request reprint The hepatocyte growth factor regulatory factors in human breast cancer
    Christian Parr
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    Clin Cancer Res 10:202-11. 2004
    ..This study determined the expression of this HGF regulatory system in breast cancer. We examined HGF, the HGF receptor (c-Met), HGFA, matriptase, and the activation inhibitors (HAI-1 and HAI-2), tissues from patients with breast cancer...
  5. ncbi request reprint Hepatocyte growth factor activation inhibitors (HAI-1 and HAI-2) regulate HGF-induced invasion of human breast cancer cells
    Christian Parr
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, UK
    Int J Cancer 119:1176-83. 2006
    ..Overall, our data demonstrates the important roles of HAI-1 and HAI-2 in cancer metastasis, and reveals that these serine protease inhibitors display strong therapeutic potential...
  6. ncbi request reprint Quantitative analysis of lymphangiogenic markers in human colorectal cancer
    C Parr
    Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Int J Oncol 23:533-9. 2003
    ..Podoplanin expression was also increased in the cancer samples. These markers indicate an increase in lymphangiogenesis in colon cancer, and may therefore have prognostic value for colon cancer patients...
  7. ncbi request reprint Reduced vascular endothelial growth inhibitor (VEGI) expression is associated with poor prognosis in breast cancer patients
    Christian Parr
    Department of Surgery, Wales College of Medicine, Metastasis and Angiogenesis Research Group, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK
    Angiogenesis 9:73-81. 2006
    ..VEGI displays prognostic relevance as breast cancer patients with an overall poor prognosis express significantly lower levels of VEGI compared to those with a favourable prognosis...
  8. ncbi request reprint Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients
    Christian Parr
    Metastasis and Angiogenesis Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Clin Cancer Res 13:3568-76. 2007
    ..The role of matriptase-2 and its cellular function in cancer is unknown. This study aimed to provide new insights into the significance of matriptase-2 in cancer...
  9. ncbi request reprint Hepatocyte growth factor activators, inhibitors and antagonists and their implication in cancer intervention
    C Parr
    University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Histol Histopathol 16:251-68. 2001
    ..This article overviews the activators, inhibitors, and antagonists to HGF/SF and discusses the possible implications in cancer therapy...
  10. ncbi request reprint Nk4, a new HGF/SF variant, is an antagonist to the influence of HGF/SF on the motility and invasion of colon cancer cells
    C Parr
    University Department of Surgery, University of Wales College of Medicine, Cardiff, UK
    Int J Cancer 85:563-70. 2000
    ..Our results show that the ability of HGF/SF to stimulate tumour cell motility and invasion, properties required for metastatic spread, can be inhibited by NK4. Thus, NK4 may have an important role in the control of cancer metastasis...
  11. ncbi request reprint Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells
    C Parr
    Metastasis Research Group, Department of Surgery, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    Int J Oncol 19:857-63. 2001
    ....
  12. ncbi request reprint The HGF/SF-induced phosphorylation of paxillin, matrix adhesion, and invasion of prostate cancer cells were suppressed by NK4, an HGF/SF variant
    C Parr
    Department of Surgery, Department of Oncology, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom
    Biochem Biophys Res Commun 285:1330-7. 2001
    ....
  13. doi request reprint Metastasis suppressor 1 (MTSS1) demonstrates prognostic value and anti-metastatic properties in breast cancer
    Christian Parr
    Metastasis and Angiogenesis Research Group, Department of Surgery, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Eur J Cancer 45:1673-83. 2009
    ..We conclude that MTSS1 is a prognostic indicator of disease-free survival in breast cancer patients and demonstrates the ability to play a role in governing the metastatic nature of breast cancer cells...
  14. ncbi request reprint Tumour endothelial marker 8 (TEM-8) in human colon cancer and its association with tumour progression
    K A Rmali
    Metastasis and Angiogenesis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Eur J Surg Oncol 30:948-53. 2004
    ..Tumour endothelial marker-8 (TEM-8) is endothelial cell surface marker that may be specific to tumour endothelial cells. This study examined the role of TEM-8 in human colon cancer and its correlation with tumour prognosis...
  15. ncbi request reprint Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in vitro angiogenesis of human vascular endothelial cells
    W G Jiang
    University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    Clin Cancer Res 5:3695-703. 1999
    ..It inhibits HGF-induced endothelial movement and tubule formation. Thus, NK4 may have an important bearing on the control of cancer progression through its role in angiogenesis. Additional in vivo studies are warranted...
  16. doi request reprint Genetic upregulation of matriptase-2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation
    Andrew J Sanders
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, UK
    J Cell Physiol 216:780-9. 2008
    ..Furthermore, the data presented implies a possible connection between matriptase-2 and the paxillin and FAK adhesion molecules which may ultimately contribute to the reduced migration rates seen in this study...
  17. ncbi request reprint Genetic reduction of matriptase-1 expression is associated with a reduction in the aggressive phenotype of prostate cancer cells in vitro and in vivo
    Andrew J Sanders
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Exp Ther Oncol 6:39-48. 2006
    ..In the current study we assessed the efficacy of targeting matriptase-1 using ribozyme technology in vitro and in vivo...
  18. pmc Stromal cell derived factor-1: its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer
    Hua Kang
    Wales College of Medicine, Cardiff University, Cardiff, UK
    Breast Cancer Res 7:R402-10. 2005
    ....
  19. ncbi request reprint Decreased pigment epithelium-derived factor expression in human breast cancer progression
    Jun Cai
    Cell and Molecular Biology Group, School of Optometry and Vision Sciences, Wales College of Medicine, Cardiff University, United Kingdom
    Clin Cancer Res 12:3510-7. 2006
    ..The aim of this study was to correlate the expression of pigment epithelium-derived factor (PEDF), a potent endogenous antiangiogenic molecule, with severity and prognosis in breast cancer...
  20. ncbi request reprint Suppression of hepatocyte growth factor activator inhibitor-1 leads to a more aggressive phenotype of prostate cancer cells in vitro
    Andrew J Sanders
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Int J Mol Med 20:613-9. 2007
    ..This implies that therapies inducing the overexpression of HAI-1 or delivering an exogenous source of HAI-1 protein may hold potential as a treatment to slow the progression of prostate cancer...
  21. ncbi request reprint Upregulation of tumour endothelial marker-8 by interleukin-1beta and its impact in IL-1beta induced angiogenesis
    Khaled A Rmali
    Metastasis and Angiogenesis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Int J Mol Med 14:75-80. 2004
    ..It is concluded that IL-1beta is a powerful regulator of the expression of TEM-8 in vascular endothelial cells. Our results suggest an important pathway through which IL-1beta regulates tumour-associated angiogenesis...
  22. ncbi request reprint Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist
    Tracey A Martin
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Carcinogenesis 24:1317-23. 2003
    ..This may occur by decreasing angiogenesis. This gives a clear indication of the therapeutic worth of NK4...
  23. ncbi request reprint Targeting matrilysin and its impact on tumor growth in vivo: the potential implications in breast cancer therapy
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Clin Cancer Res 11:6012-9. 2005
    ..The current study examined if targeting matrilysin using retroviral ribozyme transgenes may have an impact on breast cancer cells and may have clinical implications...
  24. ncbi request reprint Hepatocyte growth factor, its receptor, and their potential value in cancer therapies
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Crit Rev Oncol Hematol 53:35-69. 2005
    ..The current article discusses the potential value of HGF and its receptor as targets in cancer therapies, the current development in anti-HGF research, and the clinical value of HGF in prognosis and treatment...
  25. ncbi request reprint The HGF/SF antagonist NK4 reverses fibroblast- and HGF-induced prostate tumor growth and angiogenesis in vivo
    Gaynor Davies
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Int J Cancer 106:348-54. 2003
    ..Finally, our study provides evidence of the therapeutic potential of NK4 in prostate cancer development by antagonising HGF/SF-mediated events...
  26. ncbi request reprint The potential lymphangiogenic effects of hepatocyte growth factor/scatter factor in vitro and in vivo
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, UK
    Int J Mol Med 16:723-8. 2005
    ..Hepatocyte growth factor has potential lymphangiogenic activities, and this may have important implications in the nodal spread of cancer cells...
  27. ncbi request reprint Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET
    Wen G Jiang
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Clin Cancer Res 9:4274-81. 2003
    ..This study examined if inhibition of HGF/SF receptor expression by cancer cells and HGF/SF expression by stromal fibroblasts affects the growth of mammary cancer...
  28. ncbi request reprint Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells
    Wen G Jiang
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, CF14 4XN, UK
    Int J Mol Med 17:583-90. 2006
    ..It is highly expressed in aggressive breast tumours and is associated with clinical outcome. The enzyme is a potential therapeutic target in breast cancer...
  29. ncbi request reprint Hepatocyte growth factor/scatter factor and prostate cancer: a review
    R A Hurle
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Heath Park, Cardiff UK
    Histol Histopathol 20:1339-49. 2005
    ..This article reviews the published evidence of the roles HGF/SF plays in prostate cancer progression and highlights the clinical and therapeutic potential of research into this pleiomorphic cytokine...
  30. ncbi request reprint Biphasic effects of 17-beta-estradiol on expression of occludin and transendothelial resistance and paracellular permeability in human vascular endothelial cells
    Lin Ye
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    J Cell Physiol 196:362-9. 2003
    ....