Research Topics
Genomes and Genes
| Jack van HorssenSummaryAffiliation: VU University Medical Center Country: The Netherlands Publications
| Collaborators
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Detail Information
Publications
Myelin alters the inflammatory phenotype of macrophages by activating PPARsJeroen F J Bogie
Biomedical Research Institute, School of Life Sciences, Hasselt University Transnational University Limburg, Diepenbeek, Belgium
Acta Neuropathol Commun 1:43. 2013..Recent studies have described an altered phenotype of macrophages after myelin internalization. However, mechanisms by which myelin affects the phenotype of macrophages and how this phenotype influences lesion progression remain unclear...
Basement membrane proteins in multiple sclerosis-associated inflammatory cuffs: potential role in influx and transport of leukocytesJack van Horssen
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
J Neuropathol Exp Neurol 64:722-9. 2005....
Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesionsJack van Horssen
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Free Radic Biol Med 49:1283-9. 2010....- The role of mitochondria in axonal degeneration and tissue repair in MSJ van Horssen
Department of Molecular Cell Biology and Immunology, VU University Medical Center, The Netherlands
Mult Scler 18:1058-67. 2012..Finally, we will briefly review therapeutic strategies aimed at improving mitochondrial metabolism and function under neuroinflammatory conditions... - Radical changes in multiple sclerosis pathogenesisJack van Horssen
Departments of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Biochim Biophys Acta 1812:141-50. 2011..In addition, we will discuss clinical and experimental studies highlighting the therapeutic potential of antioxidant protection in the pathogenesis of MS... - The extracellular matrix in multiple sclerosis pathologyJack van Horssen
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
J Neurochem 103:1293-301. 2007..Increased knowledge of the expression and functional role of ECM proteins in the CNS can lead to a better understanding of complex neurobiological processes both under normal as well as pathological conditions... - Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expressionJ van Horssen
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Free Radic Biol Med 45:1729-37. 2008..Enhanced antioxidant enzyme production in inflammatory MS lesions may reflect an adaptive defense mechanism to reduce ROS-induced cellular damage... - The blood-brain barrier in cortical multiple sclerosis lesionsJack van Horssen
Department of Molecular Cell Biology, VU Medical Center Amsterdam, The Netherlands
J Neuropathol Exp Neurol 66:321-8. 2007..Our data may indicate that BBB breakdown is not a critical event in the formation of gray matter MS lesions... - Matrix metalloproteinase-19 is highly expressed in active multiple sclerosis lesionsJ van Horssen
Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
Neuropathol Appl Neurobiol 32:585-93. 2006.... - Extensive extracellular matrix depositions in active multiple sclerosis lesionsJack van Horssen
Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Neurobiol Dis 24:484-91. 2006..We postulate that these BM networks may play a role in the further recruitment of inflammatory cells and form a barrier for axonal regeneration... - NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesionsJack van Horssen
Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, P O Box 7057, 1007 MB Amsterdam, The Netherlands
Free Radic Biol Med 41:311-7. 2006..Compounds that induce the production of endogenous antioxidant enzymes, such as NQO1, may be potential targets for future treatment strategies in MS... - Clusters of activated microglia in normal-appearing white matter show signs of innate immune activationJack van Horssen
Department of Molecular Cell Biology and Immunology Neuropathology, VU University Medical Center, Van der Boechorststraat 7, 1081, BT, Amsterdam, The Netherlands
J Neuroinflammation 9:156. 2012..The aim of this study was to gain more insight into the frequency, distribution and cellular architecture of preactive lesions using a large cohort of well-characterized MS brain samples... - Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortexMaarten E Witte
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Acta Neuropathol 125:231-43. 2013..Taken together, our data indicate that reduced neuronal PGC-1α expression in MS cortex partly underlies mitochondrial dysfunction in MS grey matter and thereby contributes to neurodegeneration in MS cortex... - Neuroinflammation and blood-brain barrier changes in capillary amyloid angiopathyAnna Carrano
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands a carrano vumc nl
Neurodegener Dis 10:329-31. 2012..Cases with capCAA and no other AD-related changes allow studying capCAA-associated BBB alterations independent of AD pathology... - Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathyAnna Carrano
Department of Molecular Cell Biology and Immunology MCBI, VU University Medical Center, Amsterdam, The Netherlands
Antioxid Redox Signal 15:1167-78. 2011..Taken together, our data evidently show that Aβ is toxic to brain endothelial cells via binding to RAGE and induction of ROS production, which ultimately leads to disruption of TJs and loss of BBB integrity... - Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytesRuben van Doorn
Department of Molecular Cell Biology and Immunology, MS Center Amsterdam, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
Acta Neuropathol 124:397-410. 2012.... - Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesisGijs Kooij
Blood Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, The Netherlands
Brain 134:555-70. 2011.... - Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesionsRuben van Doorn
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Glia 58:1465-76. 2010..Results from this study indicate that astrocytes may act as a yet-unknown target within the CNS for the anti-inflammatory effects observed after FTY720P administration in the treatment of MS... - Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disordersMicha M M Wilhelmus
Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
Free Radic Biol Med 53:983-92. 2012.... - Enhanced number and activity of mitochondria in multiple sclerosis lesionsMaarten E Witte
Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
J Pathol 219:193-204. 2009..Together, these findings support a mechanism whereby enhanced density of mitochondria in MS lesions might contribute to the formation of free radicals and subsequent tissue damage... - T lymphocytes impair P-glycoprotein function during neuroinflammationGijs Kooij
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
J Autoimmun 34:416-25. 2010..Loss of vascular P-gp function during neuroinflammation may disturb brain homeostasis and thereby aggravate disease progression via exposure of vulnerable CNS cells to detrimental compounds... - Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesionsMicha M M Wilhelmus
Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
Free Radic Biol Med 50:469-76. 2011.... - Astrocyte-derived retinoic acid: a novel regulator of blood-brain barrier function in multiple sclerosisMark R Mizee
Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
Acta Neuropathol 128:691-703. 2014..A better understanding of RA signaling in MS pathophysiology may lead to the discovery of novel targets to halt disease progression. .. - Roles for HB-EGF and CD9 in multiple sclerosisGeert J Schenk
Department of Anatomy and Neurosciences, Section of Clinical Neuroscience, VU University Medical Center, Amsterdam, The Netherlands Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
Glia 61:1890-905. 2013..Together, we demonstrate that these molecules are likely implicated in processes that are highly relevant for MS lesion formation, and therefore, HB-EGF and TSPs are promising therapeutic targets... - Appearance of tissue transglutaminase in astrocytes in multiple sclerosis lesions: a role in cell adhesion and migration?Miriam E van Strien
VU University Medical Center, Neuroscience Campus Amsterdam, Department of Anatomy and Neurosciences Pathology Molecular Cell Biology and Immunology, Amsterdam, The Netherlands
Brain Pathol 21:44-54. 2011.... - Meningeal inflammation is not associated with cortical demyelination in chronic multiple sclerosisEvert Jan Kooi
Departments of Pathology Neuropathology University Medical Center, Amsterdam, The Netherlands
J Neuropathol Exp Neurol 68:1021-8. 2009..In addition, no follicle-like structures were found in the MS samples. Our data suggest that the occurrence of cortical lesions is not related to the presence of meningeal inflammation in a large number of chronic MS patients... - Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesionsPhilip G Nijland
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Glia 62:1125-41. 2014.... - Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathologyGerty Schreibelt
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Brain Res Rev 56:322-30. 2007..We propose that antioxidants may inhibit the development and progression of MS lesions and may therefore represent an attractive therapeutic target for the treatment of MS and other oxidative stress-related neurological diseases... - Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration?Maarten E Witte
Department of Pathology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
Mitochondrion 10:411-8. 2010..Here we describe the involvement of mitochondrial (dys)function in various neurological disorders and discuss the putative link between mitochondrial function and neuroinflammation... - Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrierRuben van Doorn
Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands
J Neuroinflammation 9:133. 2012..Here we demonstrate that the brain endothelial receptor S1P5 largely contributes to the maintenance of brain endothelial barrier function... - Parkinson's disease-associated parkin colocalizes with Alzheimer's disease and multiple sclerosis brain lesionsMaarten E Witte
Department of Pathology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
Neurobiol Dis 36:445-52. 2009..Our data indicate that parkin is upregulated in AD and MS brain tissue and might represent a defense mechanism to counteract stress-induced damage in AD and MS pathogenesis... - Cholinergic imbalance in the multiple sclerosis hippocampusEvert Jan Kooi
Department of Pathology Neuropathology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
Acta Neuropathol 122:313-22. 2011..Our findings reveal an MS-specific cholinergic imbalance in the hippocampus, which may be instrumental in terms of future treatment options for memory problems in this disease... - Protective effects of peroxiredoxin-1 at the injured blood-brain barrierGerty Schreibelt
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Free Radic Biol Med 45:256-64. 2008..On the other hand, it may function as an endogenous defense mechanism to inhibit leukocyte infiltration and counteract ROS-induced cellular injury... - Protective effects of monomethyl fumarate at the inflamed blood-brain barrierJamie L Lim
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands Electronic address
Microvasc Res 105:61-9. 2016..The aim of the current study was to elucidate the therapeutic effects of monomethyl fumarate on inflammatory-mediated changes in blood-brain barrier function and gain insight into the underlying mechanism... - Antioxidative defense mechanisms controlled by Nrf2: state-of-the-art and clinical perspectives in neurodegenerative diseasesJamie L Lim
Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
Arch Toxicol 88:1773-86. 2014..We here provide a comprehensive synopsis on the role of ROS in common neurodegenerative disorders and discuss the therapeutic potential of the Nrf2 pathway. .. - ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathyAnna Carrano
Department of Pathology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
Neurobiol Aging 35:565-75. 2014..Loss of P-gp expression or activity may serve as a selective biomarker for ongoing capCAA... - P-glycoprotein acts as an immunomodulator during neuroinflammationGijs Kooij
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
PLoS ONE 4:e8212. 2009..P-gp generally drives cellular efflux of a variety of compounds and is thought to be involved in excretion of inflammatory agents from immune cells, like DCs. So far, the immunomodulatory role of these ABC transporters is unknown... - Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease?Helga E de Vries
Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
Free Radic Biol Med 45:1375-83. 2008.... - Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesionsPhilip G Nijland
Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
Acta Neuropathol Commun 3:79. 2015.... - Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation statusDaphne Y S Vogel
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechhorststraat 7, BT Amsterdam, 1081, The Netherlands
J Neuroinflammation 10:35. 2013..Stimulation of monocyte-derived macrophages in vitro with interferon-γ and lipopolysaccharide results in classically activated (CA/M1) macrophages, and activation with interleukin 4 induces alternatively activated (AA/M2) macrophages... - Protandim Protects Oligodendrocytes against an Oxidative InsultJamie L Lim
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Neuroscience Campus Amsterdam, 1081 HZ Amsterdam, The Netherlands
Antioxidants (Basel) 5:. 2016.... - MLC1 is associated with the dystrophin-glycoprotein complex at astrocytic endfeetIlja Boor
Department of Pediatrics Child Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Acta Neuropathol 114:403-10. 2007..We demonstrated a direct protein interaction between MLC1 and Kir4.1. From these results we conclude that MLC1 is associated with the DGC at astrocytic endfeet... - Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosisJack van Horssen
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Mult Scler Relat Disord 8:11-8. 2016.... - The Role of ATP-Binding Cassette Transporters in Neuro-Inflammation: Relevance for Bioactive LipidsGijs Kooij
Blood Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Netherlands
Front Pharmacol 3:74. 2012..A thorough understanding of these events may form the basis for the development for selective treatment modalities to dampen the neuro-inflammatory attack in MS and thereby reducing tissue damage... - Characteristics of dyshoric capillary cerebral amyloid angiopathyEdo Richard
Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Neuropathol Exp Neurol 69:1158-67. 2010..These results suggest that capCAA is pathologically and possibly pathogenetically distinct from larger vessel CAA, and that it is associated with a high APOE-ε4 allele frequency... - Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosisMaarten E Witte
Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1081BT, Amsterdam, The Netherlands Electronic address
Trends Mol Med 20:179-87. 2014..Importantly, more insight into the cause and consequences of impaired mitochondrial function provide a basis for mitochondrial-targeted medicine to combat progressive MS. ..