Jack van Horssen

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Myelin alters the inflammatory phenotype of macrophages by activating PPARs
    Jeroen F J Bogie
    Biomedical Research Institute, School of Life Sciences, Hasselt University Transnational University Limburg, Diepenbeek, Belgium
    Acta Neuropathol Commun 1:43. 2013
  2. ncbi request reprint Basement membrane proteins in multiple sclerosis-associated inflammatory cuffs: potential role in influx and transport of leukocytes
    Jack van Horssen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 64:722-9. 2005
  3. doi request reprint Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions
    Jack van Horssen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Free Radic Biol Med 49:1283-9. 2010
  4. doi request reprint The role of mitochondria in axonal degeneration and tissue repair in MS
    J van Horssen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, The Netherlands
    Mult Scler 18:1058-67. 2012
  5. doi request reprint Radical changes in multiple sclerosis pathogenesis
    Jack van Horssen
    Departments of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Biochim Biophys Acta 1812:141-50. 2011
  6. ncbi request reprint The extracellular matrix in multiple sclerosis pathology
    Jack van Horssen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Neurochem 103:1293-301. 2007
  7. doi request reprint Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression
    J van Horssen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Free Radic Biol Med 45:1729-37. 2008
  8. ncbi request reprint The blood-brain barrier in cortical multiple sclerosis lesions
    Jack van Horssen
    Department of Molecular Cell Biology, VU Medical Center Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 66:321-8. 2007
  9. ncbi request reprint Matrix metalloproteinase-19 is highly expressed in active multiple sclerosis lesions
    J van Horssen
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
    Neuropathol Appl Neurobiol 32:585-93. 2006
  10. ncbi request reprint Extensive extracellular matrix depositions in active multiple sclerosis lesions
    Jack van Horssen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurobiol Dis 24:484-91. 2006

Collaborators

Detail Information

Publications46

  1. pmc Myelin alters the inflammatory phenotype of macrophages by activating PPARs
    Jeroen F J Bogie
    Biomedical Research Institute, School of Life Sciences, Hasselt University Transnational University Limburg, Diepenbeek, Belgium
    Acta Neuropathol Commun 1:43. 2013
    ..Recent studies have described an altered phenotype of macrophages after myelin internalization. However, mechanisms by which myelin affects the phenotype of macrophages and how this phenotype influences lesion progression remain unclear...
  2. ncbi request reprint Basement membrane proteins in multiple sclerosis-associated inflammatory cuffs: potential role in influx and transport of leukocytes
    Jack van Horssen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 64:722-9. 2005
    ....
  3. doi request reprint Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions
    Jack van Horssen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Free Radic Biol Med 49:1283-9. 2010
    ....
  4. doi request reprint The role of mitochondria in axonal degeneration and tissue repair in MS
    J van Horssen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, The Netherlands
    Mult Scler 18:1058-67. 2012
    ..Finally, we will briefly review therapeutic strategies aimed at improving mitochondrial metabolism and function under neuroinflammatory conditions...
  5. doi request reprint Radical changes in multiple sclerosis pathogenesis
    Jack van Horssen
    Departments of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Biochim Biophys Acta 1812:141-50. 2011
    ..In addition, we will discuss clinical and experimental studies highlighting the therapeutic potential of antioxidant protection in the pathogenesis of MS...
  6. ncbi request reprint The extracellular matrix in multiple sclerosis pathology
    Jack van Horssen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Neurochem 103:1293-301. 2007
    ..Increased knowledge of the expression and functional role of ECM proteins in the CNS can lead to a better understanding of complex neurobiological processes both under normal as well as pathological conditions...
  7. doi request reprint Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression
    J van Horssen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Free Radic Biol Med 45:1729-37. 2008
    ..Enhanced antioxidant enzyme production in inflammatory MS lesions may reflect an adaptive defense mechanism to reduce ROS-induced cellular damage...
  8. ncbi request reprint The blood-brain barrier in cortical multiple sclerosis lesions
    Jack van Horssen
    Department of Molecular Cell Biology, VU Medical Center Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 66:321-8. 2007
    ..Our data may indicate that BBB breakdown is not a critical event in the formation of gray matter MS lesions...
  9. ncbi request reprint Matrix metalloproteinase-19 is highly expressed in active multiple sclerosis lesions
    J van Horssen
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
    Neuropathol Appl Neurobiol 32:585-93. 2006
    ....
  10. ncbi request reprint Extensive extracellular matrix depositions in active multiple sclerosis lesions
    Jack van Horssen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurobiol Dis 24:484-91. 2006
    ..We postulate that these BM networks may play a role in the further recruitment of inflammatory cells and form a barrier for axonal regeneration...
  11. ncbi request reprint NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions
    Jack van Horssen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Free Radic Biol Med 41:311-7. 2006
    ..Compounds that induce the production of endogenous antioxidant enzymes, such as NQO1, may be potential targets for future treatment strategies in MS...
  12. pmc Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation
    Jack van Horssen
    Department of Molecular Cell Biology and Immunology Neuropathology, VU University Medical Center, Van der Boechorststraat 7, 1081, BT, Amsterdam, The Netherlands
    J Neuroinflammation 9:156. 2012
    ..The aim of this study was to gain more insight into the frequency, distribution and cellular architecture of preactive lesions using a large cohort of well-characterized MS brain samples...
  13. doi request reprint Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex
    Maarten E Witte
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Acta Neuropathol 125:231-43. 2013
    ..Taken together, our data indicate that reduced neuronal PGC-1α expression in MS cortex partly underlies mitochondrial dysfunction in MS grey matter and thereby contributes to neurodegeneration in MS cortex...
  14. doi request reprint Neuroinflammation and blood-brain barrier changes in capillary amyloid angiopathy
    Anna Carrano
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands a carrano vumc nl
    Neurodegener Dis 10:329-31. 2012
    ..Cases with capCAA and no other AD-related changes allow studying capCAA-associated BBB alterations independent of AD pathology...
  15. doi request reprint Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy
    Anna Carrano
    Department of Molecular Cell Biology and Immunology MCBI, VU University Medical Center, Amsterdam, The Netherlands
    Antioxid Redox Signal 15:1167-78. 2011
    ..Taken together, our data evidently show that Aβ is toxic to brain endothelial cells via binding to RAGE and induction of ROS production, which ultimately leads to disruption of TJs and loss of BBB integrity...
  16. doi request reprint Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes
    Ruben van Doorn
    Department of Molecular Cell Biology and Immunology, MS Center Amsterdam, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Acta Neuropathol 124:397-410. 2012
    ....
  17. doi request reprint Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis
    Gijs Kooij
    Blood Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, The Netherlands
    Brain 134:555-70. 2011
    ....
  18. doi request reprint Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions
    Ruben van Doorn
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Glia 58:1465-76. 2010
    ..Results from this study indicate that astrocytes may act as a yet-unknown target within the CNS for the anti-inflammatory effects observed after FTY720P administration in the treatment of MS...
  19. doi request reprint Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Free Radic Biol Med 53:983-92. 2012
    ....
  20. doi request reprint Enhanced number and activity of mitochondria in multiple sclerosis lesions
    Maarten E Witte
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    J Pathol 219:193-204. 2009
    ..Together, these findings support a mechanism whereby enhanced density of mitochondria in MS lesions might contribute to the formation of free radicals and subsequent tissue damage...
  21. doi request reprint T lymphocytes impair P-glycoprotein function during neuroinflammation
    Gijs Kooij
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Autoimmun 34:416-25. 2010
    ..Loss of vascular P-gp function during neuroinflammation may disturb brain homeostasis and thereby aggravate disease progression via exposure of vulnerable CNS cells to detrimental compounds...
  22. doi request reprint Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Free Radic Biol Med 50:469-76. 2011
    ....
  23. doi request reprint Astrocyte-derived retinoic acid: a novel regulator of blood-brain barrier function in multiple sclerosis
    Mark R Mizee
    Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Acta Neuropathol 128:691-703. 2014
    ..A better understanding of RA signaling in MS pathophysiology may lead to the discovery of novel targets to halt disease progression. ..
  24. doi request reprint Roles for HB-EGF and CD9 in multiple sclerosis
    Geert J Schenk
    Department of Anatomy and Neurosciences, Section of Clinical Neuroscience, VU University Medical Center, Amsterdam, The Netherlands Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Glia 61:1890-905. 2013
    ..Together, we demonstrate that these molecules are likely implicated in processes that are highly relevant for MS lesion formation, and therefore, HB-EGF and TSPs are promising therapeutic targets...
  25. doi request reprint Appearance of tissue transglutaminase in astrocytes in multiple sclerosis lesions: a role in cell adhesion and migration?
    Miriam E van Strien
    VU University Medical Center, Neuroscience Campus Amsterdam, Department of Anatomy and Neurosciences Pathology Molecular Cell Biology and Immunology, Amsterdam, The Netherlands
    Brain Pathol 21:44-54. 2011
    ....
  26. doi request reprint Meningeal inflammation is not associated with cortical demyelination in chronic multiple sclerosis
    Evert Jan Kooi
    Departments of Pathology Neuropathology University Medical Center, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 68:1021-8. 2009
    ..In addition, no follicle-like structures were found in the MS samples. Our data suggest that the occurrence of cortical lesions is not related to the presence of meningeal inflammation in a large number of chronic MS patients...
  27. doi request reprint Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions
    Philip G Nijland
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Glia 62:1125-41. 2014
    ....
  28. ncbi request reprint Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology
    Gerty Schreibelt
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Brain Res Rev 56:322-30. 2007
    ..We propose that antioxidants may inhibit the development and progression of MS lesions and may therefore represent an attractive therapeutic target for the treatment of MS and other oxidative stress-related neurological diseases...
  29. doi request reprint Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration?
    Maarten E Witte
    Department of Pathology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Mitochondrion 10:411-8. 2010
    ..Here we describe the involvement of mitochondrial (dys)function in various neurological disorders and discuss the putative link between mitochondrial function and neuroinflammation...
  30. pmc Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier
    Ruben van Doorn
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands
    J Neuroinflammation 9:133. 2012
    ..Here we demonstrate that the brain endothelial receptor S1P5 largely contributes to the maintenance of brain endothelial barrier function...
  31. doi request reprint Parkinson's disease-associated parkin colocalizes with Alzheimer's disease and multiple sclerosis brain lesions
    Maarten E Witte
    Department of Pathology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Dis 36:445-52. 2009
    ..Our data indicate that parkin is upregulated in AD and MS brain tissue and might represent a defense mechanism to counteract stress-induced damage in AD and MS pathogenesis...
  32. pmc Cholinergic imbalance in the multiple sclerosis hippocampus
    Evert Jan Kooi
    Department of Pathology Neuropathology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Acta Neuropathol 122:313-22. 2011
    ..Our findings reveal an MS-specific cholinergic imbalance in the hippocampus, which may be instrumental in terms of future treatment options for memory problems in this disease...
  33. doi request reprint Protective effects of peroxiredoxin-1 at the injured blood-brain barrier
    Gerty Schreibelt
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Free Radic Biol Med 45:256-64. 2008
    ..On the other hand, it may function as an endogenous defense mechanism to inhibit leukocyte infiltration and counteract ROS-induced cellular injury...
  34. doi request reprint Protective effects of monomethyl fumarate at the inflamed blood-brain barrier
    Jamie L Lim
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands Electronic address
    Microvasc Res 105:61-9. 2016
    ..The aim of the current study was to elucidate the therapeutic effects of monomethyl fumarate on inflammatory-mediated changes in blood-brain barrier function and gain insight into the underlying mechanism...
  35. doi request reprint Antioxidative defense mechanisms controlled by Nrf2: state-of-the-art and clinical perspectives in neurodegenerative diseases
    Jamie L Lim
    Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Arch Toxicol 88:1773-86. 2014
    ..We here provide a comprehensive synopsis on the role of ROS in common neurodegenerative disorders and discuss the therapeutic potential of the Nrf2 pathway. ..
  36. doi request reprint ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy
    Anna Carrano
    Department of Pathology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 35:565-75. 2014
    ..Loss of P-gp expression or activity may serve as a selective biomarker for ongoing capCAA...
  37. pmc P-glycoprotein acts as an immunomodulator during neuroinflammation
    Gijs Kooij
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 4:e8212. 2009
    ..P-gp generally drives cellular efflux of a variety of compounds and is thought to be involved in excretion of inflammatory agents from immune cells, like DCs. So far, the immunomodulatory role of these ABC transporters is unknown...
  38. doi request reprint Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease?
    Helga E de Vries
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Free Radic Biol Med 45:1375-83. 2008
    ....
  39. pmc Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesions
    Philip G Nijland
    Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Acta Neuropathol Commun 3:79. 2015
    ....
  40. pmc Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
    Daphne Y S Vogel
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechhorststraat 7, BT Amsterdam, 1081, The Netherlands
    J Neuroinflammation 10:35. 2013
    ..Stimulation of monocyte-derived macrophages in vitro with interferon-γ and lipopolysaccharide results in classically activated (CA/M1) macrophages, and activation with interleukin 4 induces alternatively activated (AA/M2) macrophages...
  41. pmc Protandim Protects Oligodendrocytes against an Oxidative Insult
    Jamie L Lim
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Neuroscience Campus Amsterdam, 1081 HZ Amsterdam, The Netherlands
    Antioxidants (Basel) 5:. 2016
    ....
  42. pmc MLC1 is associated with the dystrophin-glycoprotein complex at astrocytic endfeet
    Ilja Boor
    Department of Pediatrics Child Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Acta Neuropathol 114:403-10. 2007
    ..We demonstrated a direct protein interaction between MLC1 and Kir4.1. From these results we conclude that MLC1 is associated with the DGC at astrocytic endfeet...
  43. doi request reprint Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosis
    Jack van Horssen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Mult Scler Relat Disord 8:11-8. 2016
    ....
  44. pmc The Role of ATP-Binding Cassette Transporters in Neuro-Inflammation: Relevance for Bioactive Lipids
    Gijs Kooij
    Blood Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Netherlands
    Front Pharmacol 3:74. 2012
    ..A thorough understanding of these events may form the basis for the development for selective treatment modalities to dampen the neuro-inflammatory attack in MS and thereby reducing tissue damage...
  45. doi request reprint Characteristics of dyshoric capillary cerebral amyloid angiopathy
    Edo Richard
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 69:1158-67. 2010
    ..These results suggest that capCAA is pathologically and possibly pathogenetically distinct from larger vessel CAA, and that it is associated with a high APOE-ε4 allele frequency...
  46. doi request reprint Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis
    Maarten E Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1081BT, Amsterdam, The Netherlands Electronic address
    Trends Mol Med 20:179-87. 2014
    ..Importantly, more insight into the cause and consequences of impaired mitochondrial function provide a basis for mitochondrial-targeted medicine to combat progressive MS. ..