Jos Paulusse


Affiliation: Twente University - Biomedical Chemistry
Location: Enschede, Nederland


  1. request reprint
    Paulusse J, Sijbesma R. Molecule-based rheology switching. Angew Chem Int Ed Engl. 2006;45:2334-7 pubmed
  2. Ruizendaal L, Pujari S, Gevaerts V, Paulusse J, Zuilhof H. Biofunctional silicon nanoparticles by means of thiol-ene click chemistry. Chem Asian J. 2011;6:2776-86 pubmed publisher
    ..Gel electrophoresis confirmed coupling of 2 to 3 DNA strands onto the SiNPs, whereas no uncoupled DNA was observed. ..
  3. Rosso M, Nguyen A, de Jong E, Baggerman J, Paulusse J, Giesbers M, et al. Protein-repellent silicon nitride surfaces: UV-induced formation of oligoethylene oxide monolayers. ACS Appl Mater Interfaces. 2011;3:697-704 pubmed publisher
    ..Highly stable antifouling coatings on Si(x)N(4) surfaces significantly broaden the application potential of silicon nitride-coated microdevices, and in particular of microfabricated filtration membranes...
  4. Campos M, Trilling A, Yang M, Giesbers M, Beekwilder J, Paulusse J, et al. Self-assembled functional organic monolayers on oxide-free copper. Langmuir. 2011;27:8126-33 pubmed publisher
    ..In addition, the biotinylated copper surfaces were employed in the immobilization of biomolecules such as streptavidin. ..
  5. Dohnalová K, Fucíková A, Umesh C, Humpolickova J, Paulusse J, Valenta J, et al. Microscopic origin of the fast blue-green luminescence of chemically synthesized non-oxidized silicon quantum dots. Small. 2012;8:3185-91 pubmed publisher
    ..This understanding paves the way towards applications of chemical synthesis for the development of Si-QDs with tunable sizes and bandgaps. ..
  6. request reprint
    Paulusse J, Sijbesma R. Reversible mechanochemistry of a Pd(II) coordination polymer. Angew Chem Int Ed Engl. 2004;43:4460-2 pubmed
  7. Nguyen A, Baggerman J, Paulusse J, van Rijn C, Zuilhof H. Stable protein-repellent zwitterionic polymer brushes grafted from silicon nitride. Langmuir. 2011;27:2587-94 pubmed publisher
  8. Nieuwenhuizen M, de Greef T, van der Bruggen R, Paulusse J, Appel W, Smulders M, et al. Self-assembly of ureido-pyrimidinone dimers into one-dimensional stacks by lateral hydrogen bonding. Chemistry. 2010;16:1601-12 pubmed publisher
  9. Paulusse J, Sijbesma R. Selectivity of mechanochemical chain scission in mixed palladium(II) and platinum(II) coordination polymers. Chem Commun (Camb). 2008;:4416-8 pubmed publisher
    ..The selectivity of ultrasound induced chain scission was studied in reversible polymers with coordinative bonds (Pd-P and Pt-P) of different strengths in series. ..

More Information


  1. request reprint
    Paulusse J, van Beek D, Sijbesma R. Reversible switching of the sol-gel transition with ultrasound in rhodium(I) and iridium(I) coordination networks. J Am Chem Soc. 2007;129:2392-7 pubmed
    ..The observed effects offer opportunities to use ultrasound in the activation of dormant transition metal catalysts. ..
  2. request reprint
    Paulusse J, Huijbers J, Sijbesma R. Quantification of ultrasound-induced chain scission in PdII-phosphine coordination polymers. Chemistry. 2006;12:4928-34 pubmed
    ..These results show that the system of 3 in combination with scavenger 4 is a suitable system to study the efficiency of ultrasound-induced chain scission of coordination polymers. ..
  3. Campos M, Paulusse J, Zuilhof H. Functional monolayers on oxide-free silicon surfaces via thiol-ene click chemistry. Chem Commun (Camb). 2010;46:5512-4 pubmed publisher
  4. Paulusse J, Amir R, Evans R, Hawker C. Free radical polymers with tunable and selective bio- and chemical degradability. J Am Chem Soc. 2009;131:9805-12 pubmed publisher
  5. Nguyen A, Baggerman J, Paulusse J, Zuilhof H, van Rijn C. Bioconjugation of protein-repellent zwitterionic polymer brushes grafted from silicon nitride. Langmuir. 2012;28:604-10 pubmed publisher
  6. Kröger A, Paulusse J. Single-chain polymer nanoparticles in controlled drug delivery and targeted imaging. J Control Release. 2018;286:326-347 pubmed publisher
    ..This review describes how SCNPs have been rendered water-soluble and highlights ongoing research efforts towards biocompatible SCNPs with tunable properties for controlled drug delivery, targeted imaging and protein mimicry. ..
  7. Hujaya S, Marchioli G, Roelofs K, van Apeldoorn A, Moroni L, Karperien M, et al. Poly(amido amine)-based multilayered thin films on 2D and 3D supports for surface-mediated cell transfection. J Control Release. 2015;205:181-9 pubmed publisher
  8. Hujaya S, Engbersen J, Paulusse J. Multilayered thin films from poly(amido amine)s and DNA. Acta Biomater. 2015;22:19-31 pubmed publisher
  9. Hujaya S, Engbersen J, Paulusse J. Multilayered Thin Films from Boronic Acid-Functional Poly(amido amine)s As Drug-Releasing Surfaces. Pharm Res. 2015;32:3732-45 pubmed publisher
    ..These multilayered surfaces are promising as drug-releasing delivery surface for coating stents, prostheses, and other implants. ..
  10. Ekkelenkamp A, Jansman M, Roelofs K, Engbersen J, Paulusse J. Surfactant-free preparation of highly stable zwitterionic poly(amido amine) nanogels with minimal cytotoxicity. Acta Biomater. 2016;30:126-134 pubmed publisher
    ..Because of their negative surface charge and excellent serum stability, these nanogels are therefore promising carriers for drug delivery and molecular imaging. ..
  11. Gao Y, Böhmer V, Zhou D, Zhao T, Wang W, Paulusse J. Main-chain degradable single-chain cyclized polymers as gene delivery vectors. J Control Release. 2016;244:375-383 pubmed publisher
    ..The single-chain cyclized polymeric nanoparticles were evaluated for their gene transfection capabilities. The backbone degradable nanoparticles displayed high transfection efficiencies and low cytotoxicities in both 3T3 and HeLa cells. ..
  12. Elzes M, Akeroyd N, Engbersen J, Paulusse J. Disulfide-functional poly(amido amine)s with tunable degradability for gene delivery. J Control Release. 2016;244:357-365 pubmed publisher