Affiliation: University Medical Center Groningen
Country: The Netherlands
Ozgen H, Baron W, Hoekstra D, Kahya N. Oligodendroglial membrane dynamics in relation to myelin biogenesis. Cell Mol Life Sci. 2016;73:3291-310 pubmed publisher
..e., approaches which clearly provide an added value to insight obtained by classical biochemical techniques. ..
Lentferink D, Jongsma J, Werkman I, Baron W. Grey matter OPCs are less mature and less sensitive to IFNÎ³ than white matter OPCs: consequences for remyelination. Sci Rep. 2018;8:2113 pubmed publisher
..Our results demonstrate that OPCs from GM and WM differ both intrinsically and in response to their environment, which may contribute to the difference in remyelination efficiency between GM and WM MS lesions. ..
Lim J, van der Pol S, Baron W, McCord J, de Vries H, van Horssen J. Protandim Protects Oligodendrocytes against an Oxidative Insult. Antioxidants (Basel). 2016;5: pubmed publisher
Baron W, Ozgen H, Klunder B, de Jonge J, Nomden A, Plat A, et al
. The major myelin-resident protein PLP is transported to myelin membranes via a transcytotic mechanism: involvement of sulfatide. Mol Cell Biol. 2015;35:288-302 pubmed publisher
..e., transient, partitioning of PLP into distinct membrane microdomains involved in biosynthetic and transcytotic transport. ..
Bijlard M, Klunder B, de Jonge J, Nomden A, Tyagi S, de Vries H, et al
. Transcriptional expression of myelin basic protein in oligodendrocytes depends on functional syntaxin 4: a potential correlation with autocrine signaling. Mol Cell Biol. 2015;35:675-87 pubmed publisher
..These findings indicate that the initiation of the biosynthesis of MBP mRNA relies on a syntaxin 4-dependent mechanism, which likely involves activation of an autocrine signaling pathway. ..
Qin J, Sikkema A, van der Bij K, de Jonge J, Klappe K, Nies V, et al
. GD1a Overcomes Inhibition of Myelination by Fibronectin via Activation of Protein Kinase A: Implications for Multiple Sclerosis. J Neurosci. 2017;37:9925-9938 pubmed publisher
..We propose that targeted delivery of GD1a to MS lesions may act as a potential novel molecular tool to boost maturation of resident OPCs to overcome remyelination failure and halt disease progression. ..