Genomes and Genes


Reuven Agami


Affiliation: The Netherlands Cancer Institute
Country: The Netherlands


  1. Elkon R, Loayza Puch F, Korkmaz G, Lopes R, van Breugel P, Bleijerveld O, et al. Myc coordinates transcription and translation to enhance transformation and suppress invasiveness. EMBO Rep. 2015;16:1723-36 pubmed publisher
    ..Our results elucidate novel facets of Myc-induced cellular responses and provide a more comprehensive view of the consequences of its activation in cancer cells. ..
  2. Lopes R, Korkmaz G, Revilla S, van Vliet R, Nagel R, Custers L, et al. CUEDC1 is a primary target of ER? essential for the growth of breast cancer cells. Cancer Lett. 2018;: pubmed publisher
    ..Finally, CUEDC1 expression correlates positively with ER? in breast cancer. Thus, CUEDC1 is a functional target gene of ER? and is required for breast cancer cell proliferation. ..
  3. Han R, Li L, Ugalde A, Tal A, Manber Z, Barbera E, et al. Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence. Genome Biol. 2018;19:118 pubmed publisher
  4. Slobodin B, Agami R. Transcription initiation determines its end. Mol Cell. 2015;57:205-6 pubmed publisher
    ..A new study published in this issue of Molecular Cell (Oktaba et al., 2015) suggests widespread involvement of promoters in the regulation of alternative cleavage and polyadenylation of mRNAs in Drosophila neurons. ..
  5. Léveillé N, Melo C, Agami R. Enhancer-associated RNAs as therapeutic targets. Expert Opin Biol Ther. 2015;15:723-34 pubmed publisher
    ..However, thorough testing as well as providing the genetic toolbox to target eRNAs will be needed to fully assess the practical and clinical possibilities. ..
  6. Lopes R, Agami R, Korkmaz G. GRO-seq, A Tool for Identification of Transcripts Regulating Gene Expression. Methods Mol Biol. 2017;1543:45-55 pubmed publisher
    ..Here, we describe a detailed protocol of GRO-seq that can be readily applied to investigate different aspects of RNA biology in human cells. ..
  7. Slobodin B, Han R, Calderone V, Vrielink J, Loayza Puch F, Elkon R, et al. Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation. Cell. 2017;169:326-337.e12 pubmed publisher
    ..This study uncovers a general and widespread link between transcription and translation that is governed by epigenetic modification of mRNAs. ..
  8. Agami R. microRNAs, RNA binding proteins and cancer. Eur J Clin Invest. 2010;40:370-4 pubmed publisher
    ..Although miRNAs are prominent factors in cancer, little is known about how RBPs affect their cancerous function. ..
  9. Huang Q, Yan J, Agami R. Long non-coding RNAs in metastasis. Cancer Metastasis Rev. 2017;: pubmed publisher
    ..In this review, we discuss the molecular mechanisms of lncRNAs in gene expression regulation and their function in metastasis...