Genomes and Genes
Robert de Jonge
Affiliation: Erasmus MC
Country: The Netherlands
- de Jonge R, Hooijberg J, van Zelst B, Jansen G, Jansen G, van Zantwijk C, et al. Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia. Blood. 2005;106:717-20 pubmed..SHMT1 1420TT homozygotes only showed decreased MTX sensitivity in the TSI(50, cont). In conclusion, polymorphisms in the folate-related genes MTHFR, MTRR, and SHMT1 are related to MTX resistance in pediatric patients with ALL. ..
- de Jonge R, Tissing W, Hooijberg J, Jansen G, Kaspers G, Lindemans J, et al. Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia. Blood. 2009;113:2284-9 pubmed publisher..2-fold increase in ALL risk (P = .001). For the first time, we associate the RFC1 80G>A and NNMT IVS -151C>T variants to an increased ALL susceptibility. ..
- Fleming C, Russcher H, Brouwer R, Lindemans J, de Jonge R. Evaluation of Sysmex XN-1000 High-Sensitive Analysis (hsA) Research Mode for Counting and Differentiating Cells in Cerebrospinal Fluid. Am J Clin Pathol. 2016;145:299-307 pubmed publisher..99) for all parameters evaluated. Carryover was negligible and never exceeded 0.04%. The XN hsA research mode provides reliable cell counts in CSF samples, even in samples containing low numbers of WBCs and RBCs. ..
- Herzog E, Eggink A, van der Zee M, Lagendijk J, Willemsen S, de Jonge R, et al. The impact of early- and late-onset preeclampsia on umbilical cord blood cell populations. J Reprod Immunol. 2016;116:81-5 pubmed publisher..This heterogeneity in UCBC should be considered as confounder in epigenetic association studies examining EOPE. ..