Pinaki Talukdar


Affiliation: Indian Institute of Science Education and Research
Location: Pune, India


  1. Das G, Talukdar P, Matile S. Fluorometric detection of enzyme activity with synthetic supramolecular pores. Science. 2002;298:1600-2 pubmed
    ..Such detectors of enzyme activity with the aforementioned characteristics are needed in areas as diverse as proteomics and environmentally benign organic synthesis. ..
  2. Talukdar P, Sakai N, Sordé N, Gerard D, Cardona V, Matile S. Outer surface modification of synthetic multifunctional pores. Bioorg Med Chem. 2004;12:1325-36 pubmed
    ..The relation between the stability of supramolecular (pre)pores and dependence of activity on monomer concentration is discussed in a more general context. ..
  3. Talukdar P, Bollot G, Mareda J, Sakai N, Matile S. Synthetic ion channels with rigid-rod pi-stack architecture that open in response to charge-transfer complex formation. J Am Chem Soc. 2005;127:6528-9 pubmed
  4. Talukdar P, Bollot G, Mareda J, Sakai N, Matile S. Ligand-gated synthetic ion channels. Chemistry. 2005;11:6525-32 pubmed
    ..Control experiments demonstrate that minor structural changes leading to internal decrowding suffice to cleanly annihilate chiral self-organization and function. ..
  5. Sakai N, Talukdar P, Matile S. Use of the exciton chirality method in the investigation of ligand-gated synthetic ion channels. Chirality. 2006;18:91-4 pubmed
  6. Bhosale S, Sisson A, Talukdar P, Fürstenberg A, Banerji N, Vauthey E, et al. Photoproduction of proton gradients with pi-stacked fluorophore scaffolds in lipid bilayers. Science. 2006;313:84-6 pubmed
    ..Ligand intercalation transformed the photoactive scaffolds into ion channels. ..
  7. Kalle A, Mallika A, Badiger J, Alinakhi -, Talukdar P, Sachchidanand -. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. Biochem Biophys Res Commun. 2010;401:13-9 pubmed publisher
    ..In conclusion, the present study indicates the potent apoptotic effects of JGB1741 in MDA-MB 231 cells. ..
  8. Pallavi R, Roy N, Nageshan R, Talukdar P, Pavithra S, Reddy R, et al. Heat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug. J Biol Chem. 2010;285:37964-75 pubmed publisher
    ..evansi growth in a mouse model of trypanosomiasis. In all, our biochemical characterization, drug interaction, and animal studies supported Hsp90 as a drug target and its inhibitor as a potential drug against protozoan diseases...
  9. Kand D, Kalle A, Varma S, Talukdar P. A chromenoquinoline-based fluorescent off-on thiol probe for bioimaging. Chem Commun (Camb). 2012;48:2722-4 pubmed publisher
    ..Cell permeability and live cell imaging of thiols are also demonstrated. ..

More Information


  1. Mishra P, Saha T, Talukdar P. Hydrogen sulfide mediated cascade reaction forming an iminocoumarin: applications in fluorescent probe development and live-cell imaging. Org Biomol Chem. 2015;13:7430-6 pubmed publisher
    ..H2S sensing by the probe was characterized by a 31-fold fluorescence enhancement and alimit of detection of 169 nM. Application of the probe was demonstrated by imaging of H2S in live cells. ..
  2. Kand D, Saha T, Lahiri M, Talukdar P. Lysosome targeting fluorescence probe for imaging intracellular thiols. Org Biomol Chem. 2015;13:8163-8 pubmed publisher
    ..The probe displayed fast response towards biothiols in aqueous solution. Localization of the probe in lysosome was demonstrated by intracellular colocalization studies with the aid of LysoSensor Green. ..
  3. Shinde S, Talukdar P. An anion receptor that facilitates transmembrane proton-anion symport by deprotonating its sulfonamide N-H proton. Chem Commun (Camb). 2018;54:10351-10354 pubmed publisher
    ..The ion transport efficiency directly correlated to the pKa of the sulfonamide N-H protons. The mechanistic study indicated proton-anion symport across the lipid bilayer membrane. ..
  4. Roy A, Saha T, Gening M, Titov D, Gerbst A, Tsvetkov Y, et al. Trimodal Control of Ion-Transport Activity on Cyclo-oligo-(1→6)-β-D-glucosamine-Based Artificial Ion-Transport Systems. Chemistry. 2015;21:17445-52 pubmed publisher
    ..All glycoconjugates displayed a uniform anion-selectivity sequence: Cl(-) >Br(-) >I(-) . From theoretical studies, hydrogen bonding between the macrocycle backbone and the anion bridged through water molecules was observed. ..
  5. Roy A, Gautam A, Malla J, Sarkar S, Mukherjee A, Talukdar P. Self-assembly of small-molecule fumaramides allows transmembrane chloride channel formation. Chem Commun (Camb). 2018;54:2024-2027 pubmed publisher
    ..The geometry-optimized model of the channel and Cl- ion selectivity within the channel lumen was also illustrated. ..
  6. Roy A, Biswas O, Talukdar P. Bis(sulfonamide) transmembrane carriers allow pH-gated inversion of ion selectivity. Chem Commun (Camb). 2017;53:3122-3125 pubmed publisher
    ..A liposomal membrane potential is also generated when potassium ions are passively transported by these carriers. ..
  7. Chauhan D, Varma S, Gudem M, Panigrahi N, Singh K, Hazra A, et al. Intramolecular cascade rearrangements of enynamine derived ketenimines: access to acyclic and cyclic amidines. Org Biomol Chem. 2017;15:4822-4830 pubmed publisher
    ..Computational studies were carried out to validate the mechanism which indicates that the product distribution of the process depends on the substitutions on the enynamine backbone. ..