Szolnoki Z, Havasi V, Talian G, Bene J, Komlosi K, Somogyvari F, et al
. Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers. J Mol Neurosci. 2006;28:285-90 pubmed
..1, p<0.001) infarction. On a pathophysiological basis, our results suggest the possibility that the AT1R A1166C polymorphism might give rise to ischemic stroke indirectly via an unfavorable effect on the cardiorespiratory function. ..
Szolnoki Z. Evaluation of common unfavourable genetic variants in cerebrovascular diseases: recommendation for supportive genetic examinations and methodological approaches for common genetic variants. Curr Med Chem. 2009;16:3168-73 pubmed
..The development of a correct approach to genetic polymorphisms may have a great impact on the understanding and prevention of cerebrovascular diseases. ..
Szolnoki Z, Szekeres M, Szaniszlo I, Balda G, Bodor A, Kondacs A, et al
. Decreased Number of Mitochondria in Leukoaraiosis. Arch Med Res. 2015;46:604-8 pubmed publisher
..37 95% CI 0.05; controls: K 0.48, 95% CI 0.076, pÂ <Â 0.001). Our study suggests that the ratio of the dmDNA and mDNA can be of great importance in the pathogenesis of LA. ..
Szolnoki Z, Somogyvari F, Kondacs A, Szabo M, Fodor L. Evaluation of the interactions of common genetic mutations in stroke subtypes. J Neurol. 2002;249:1391-7 pubmed
..Common mutations which alone are minor or non-significant risk factors for ischemic stroke can yield, in specific combination patterns, a highly significant, moderate genetic risk of specific stroke subtypes. ..
Szolnoki Z, Serly J, Kondacs A, Mandi Y, Somogyvari F. Evaluation of the genetic variants of kinesin motor protein in ischemic stroke. J Stroke Cerebrovasc Dis. 2009;18:360-2 pubmed publisher
..The examined 3 genetic variants seem to influence the responses of the glial cells to a slight chronic hypoxia state, rather than the mechanisms resulting in cerebral infarcts themselves. ..
Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension. Clin Biochem. 2009;42:630-3 pubmed publisher
..This draws attention to a need for stricter preventive measures in CC carriers. ..
Szolnoki Z, Maasz A, Magyari L, Horvatovich K, Farago B, Kondacs A, et al
. Galectin-2 3279TT variant protects against the lymphotoxin-alpha 252GG genotype associated ischaemic stroke. Clin Neurol Neurosurg. 2009;111:227-30 pubmed publisher
..56%) than in the controls (5.94%, p<0.00187; overall stroke group: crude OR: 0.25, 95% CI: 0.1-0.64; adjusted OR: 0.03, 95% CI: 0.025-0.71). This finding suggests a gene-gene interaction. ..
Szolnoki Z, Kondacs A, Mandi Y, Somogyvari F. A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: the janus face of the kinesin light-chain 1 56836CC genetic variant. Neuromolecular Med. 2007;9:335-9 pubmed
..0% vs. 9.7%, P < 0.02; crude OR: 0.19, 95% CI: 0.04-0.82, P < 0.05; adjusted OR: 0.21, 95% CI: 0.018-0.88, P < 0.05). Our results draw attention to possible roles of the cytoskeleton in MS. ..
Szolnoki Z, Maasz A, Magyari L, Horvatovich K, Farago B, Somogyvari F, et al
. The combination of homozygous MTHFR 677T and angiotensin II type-1 receptor 1166C variants confers the risk of small-vessel-associated ischemic stroke. J Mol Neurosci. 2007;31:201-7 pubmed
..Although the exact mechanism of action is not known, addition of the unfavourable effects on the endothelial function can be presumed. ..