Affiliation: University Hospital
Linnebank M, Moskau S, Kowoll A, Semmler A, Bangard C, Vogt Schaden M, et al
. Association of transcobalamin c. 776C>G with overall survival in patients with primary central nervous system lymphoma. Br J Cancer. 2012;107:1840-3 pubmed publisher
..010) were associated with longer overall survival in a multivariate COX regression analysis. This observation suggests that the missense variant Tc2. 776C>G influences both neurotoxicity and efficacy of MTX in the Bonn PCNSL protocol. ..
Semmler A, Heese P, Stoffel Wagner B, Muschler M, Heberlein A, Bigler L, et al
. Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: results from the German Investigation on Neurobiology in Alcoholism (GINA). Alcohol. 2015;49:97-101 pubmed publisher
..This suggests a direct effect of alcohol consumption and smoking on DNA methylation, which is not mediated by effects of alcohol on homocysteine metabolism. ..
Linnebank M, Semmler A, Moskau S, Smulders Y, Blom H, Simon M. The methylenetetrahydrofolate reductase (MTHFR) variant c.677C>T (A222V) influences overall survival of patients with glioblastoma multiforme. Neuro Oncol. 2008;10:548-52 pubmed publisher
..89, p = 0.015). These data suggest the MTHFR c.677C>T variant is a risk factor for survival in GBM patients. ..
Linnebank M, Moskau S, Jürgens A, Simon M, Semmler A, Orlopp K, et al
. Association of genetic variants of methionine metabolism with methotrexate-induced CNS white matter changes in patients with primary CNS lymphoma. Neuro Oncol. 2009;11:2-8 pubmed publisher
..73; p < 0.001), in addition to male gender (chi(2) = 11.95; p = 0.001). These data strengthen the hypothesis that MTX effects are influenced by methionine metabolism, which may offer new strategies to improve MTX-based therapies. ..
Linnebank M, Popp J, Smulders Y, Smith D, Semmler A, Farkas M, et al
. S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease. Neurodegener Dis. 2010;7:373-8 pubmed publisher
..002; odds ratio 0.126, 95% confidence interval 0.32-0.49). These data suggest that AD is associated with lower CSF SAM levels and that this is at least partly due to an association of the APOE4 allele with reduced SAM levels in the CSF. ..
Linnebank M, Moskau S, Semmler A, Hoefgen B, Bopp G, Kallweit U, et al
. A possible genetic link between MTHFR genotype and smoking behavior. PLoS ONE. 2012;7:e53322 pubmed publisher
..In addition, the MTHFR variants were associated with smoking behaviour. Such an association may be a relevant confounder between MTHFR variants, homocysteine plasma levels and vascular diseases. ..