Saema Ansar

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. pmc Investigating potentially salvageable penumbra tissue in an in vivo model of transient ischemic stroke using sodium, diffusion, and perfusion magnetic resonance imaging
    Friedrich Wetterling
    Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany
    BMC Neurosci 17:82. 2016
  2. pmc MAPK signaling pathway regulates cerebrovascular receptor expression in human cerebral arteries
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    BMC Neurosci 14:12. 2013
  3. ncbi request reprint Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, 221 84 Lund, Sweden
    Am J Physiol Heart Circ Physiol 293:H3750-8. 2007
  4. pmc Inhibition of cerebrovascular raf activation attenuates cerebral blood flow and prevents upregulation of contractile receptors after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    BMC Neurosci 12:107. 2011
  5. ncbi request reprint Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, BMC A13, Lund University, 221 84 Lund, Sweden
    Stroke 39:185-90. 2008
  6. doi request reprint Equal contribution of increased intracranial pressure and subarachnoid blood to cerebral blood flow reduction and receptor upregulation after subarachnoid hemorrhage. Laboratory investigation
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    J Neurosurg 111:978-87. 2009
  7. doi request reprint Subarachnoid hemorrhage induces enhanced expression of thromboxane A2 receptors in rat cerebral arteries
    Saema Ansar
    Division of Experimental Vascular Research, Department of Clinical Sciences, Lund University, Sweden
    Brain Res 1316:163-72. 2010
  8. ncbi request reprint Cerebral ischemia induces transcription of inflammatory and extracellular-matrix-related genes in rat cerebral arteries
    Petter Vikman
    Department of Clinical Sciences, Experimental Vascular Research, BMC A13, 221 84, Lund, Sweden
    Exp Brain Res 183:499-510. 2007
  9. pmc Blockade of the MEK/ERK pathway with a raf inhibitor prevents activation of pro-inflammatory mediators in cerebral arteries and reduction in cerebral blood flow after subarachnoid hemorrhage in a rat model
    Aida Maddahi
    Division of Experimental Vascular Research, Department of Clinical Sciences, Lund University, Lund, Sweden
    J Cereb Blood Flow Metab 31:144-54. 2011
  10. ncbi request reprint Transcriptional regulation of inflammatory and extracellular matrix-regulating genes in cerebral arteries following experimental subarachnoid hemorrhage in rats. Laboratory investigation
    Petter Vikman
    Department of Clinical Sciences, Experimental Vascular Research, Lund, Sweden
    J Neurosurg 107:1015-22. 2007

Collaborators

Detail Information

Publications19

  1. pmc Investigating potentially salvageable penumbra tissue in an in vivo model of transient ischemic stroke using sodium, diffusion, and perfusion magnetic resonance imaging
    Friedrich Wetterling
    Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany
    BMC Neurosci 17:82. 2016
    ..MRI sodium, perfusion and diffusion measurement was recorded before reperfusion, shortly after reperfusion and 24 h after reperfusion. The animals were reperfused after 90 min of ischemia...
  2. pmc MAPK signaling pathway regulates cerebrovascular receptor expression in human cerebral arteries
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    BMC Neurosci 14:12. 2013
    ..The vessels were then examined by using in vitro pharmacological methods and protein immunohistochemistry...
  3. ncbi request reprint Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, 221 84 Lund, Sweden
    Am J Physiol Heart Circ Physiol 293:H3750-8. 2007
    ..These changes occur in parallel with a successive decrease in CBF. Thus there is a temporal correlation between the changes in receptor expression and CBF reduction, suggesting a linkage...
  4. pmc Inhibition of cerebrovascular raf activation attenuates cerebral blood flow and prevents upregulation of contractile receptors after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    BMC Neurosci 12:107. 2011
    ..The raf inhibitor will inhibit the molecular events upstream ERK1/2 and may provide a therapeutic window for treatment of cerebral ischemia after SAH...
  5. ncbi request reprint Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, BMC A13, Lund University, 221 84 Lund, Sweden
    Stroke 39:185-90. 2008
    ..We hypothesize that treatment with a MAPK or PKC inhibitor will prevent the SAH-induced kinase activation in brain vessels...
  6. doi request reprint Equal contribution of increased intracranial pressure and subarachnoid blood to cerebral blood flow reduction and receptor upregulation after subarachnoid hemorrhage. Laboratory investigation
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    J Neurosurg 111:978-87. 2009
    ..The purpose of this study was to examine whether the change in intracranial pressure or the extravasated blood causes the late cerebral ischemia and the upregulation of receptors or the cerebral vasoconstriction observed following SAH...
  7. doi request reprint Subarachnoid hemorrhage induces enhanced expression of thromboxane A2 receptors in rat cerebral arteries
    Saema Ansar
    Division of Experimental Vascular Research, Department of Clinical Sciences, Lund University, Sweden
    Brain Res 1316:163-72. 2010
    ..The results demonstrate that SAH results in CBF reduction and this is associated with the enhanced expression of TP receptors in the SMC of cerebral arteries and microvessels...
  8. ncbi request reprint Cerebral ischemia induces transcription of inflammatory and extracellular-matrix-related genes in rat cerebral arteries
    Petter Vikman
    Department of Clinical Sciences, Experimental Vascular Research, BMC A13, 221 84, Lund, Sweden
    Exp Brain Res 183:499-510. 2007
    ....
  9. pmc Blockade of the MEK/ERK pathway with a raf inhibitor prevents activation of pro-inflammatory mediators in cerebral arteries and reduction in cerebral blood flow after subarachnoid hemorrhage in a rat model
    Aida Maddahi
    Division of Experimental Vascular Research, Department of Clinical Sciences, Lund University, Lund, Sweden
    J Cereb Blood Flow Metab 31:144-54. 2011
    ..These results suggested that inhibition of MEK/ERK signal transduction by a specific raf inhibitor administered up to 6 hours after SAH normalized the expression of pro-inflammatory mediators and extracellular matrix-related genes...
  10. ncbi request reprint Transcriptional regulation of inflammatory and extracellular matrix-regulating genes in cerebral arteries following experimental subarachnoid hemorrhage in rats. Laboratory investigation
    Petter Vikman
    Department of Clinical Sciences, Experimental Vascular Research, Lund, Sweden
    J Neurosurg 107:1015-22. 2007
    ....
  11. ncbi request reprint Neurokinin-1 receptor antagonism in a rat model of subarachnoid hemorrhage: prevention of upregulation of contractile ETB and 5-HT1B receptors and cerebral blood flow reduction
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
    J Neurosurg 106:881-6. 2007
    ....
  12. pmc Pro-inflammatory mediators and apoptosis correlate to rt-PA response in a novel mouse model of thromboembolic stroke
    Saema Ansar
    Department of Neurology, University Medicine Mannheim, Heidelberg University, Heidelberg, Germany
    PLoS ONE 9:e85849. 2014
    ..We performed a study to elucidate possible mechanisms of this finding in a new model of thromboembolic stroke closely mimicking human pathophysiology...
  13. doi request reprint Chemical shift sodium imaging in a mouse model of thromboembolic stroke at 9.4 T
    Patrick M Heiler
    Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany
    J Magn Reson Imaging 34:935-40. 2011
    ..To estimate changes in the (23)Na density and in the (23)Na relaxation time T(2) * in the anatomically small murine brain after stroke...
  14. pmc Characterization of a new model of thromboembolic stroke in C57 black/6J mice
    Saema Ansar
    Department of Neurology, Universitatsmedizin Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Transl Stroke Res 5:526-33. 2014
    ..However, strain differences between Swiss and C57 black/6J mice must be taken into account when using the model...
  15. doi request reprint Inhibition of mitogen-activated protein kinase 1/2 in the acute phase of stroke improves long-term neurological outcome and promotes recovery processes in rats
    Maryam Mostajeran
    Division of Experimental Vascular Research, Department of Clinical Sciences, Lund University, Lund, Sweden
    Acta Physiol (Oxf) . 2015
    ..Therefore, the aim of this study was to assess neurological function, infarct size and recovery processes 14 days after stroke in male rats to determine long-term outcome following acute treatment with the MEK1/2 inhibitor U0126...
  16. doi request reprint Sodium-23 magnetic resonance imaging during and after transient cerebral ischemia: multinuclear stroke protocols for double-tuned (23)Na/(1)H resonator systems
    Friedrich Wetterling
    RF Methods and Imaging Group, Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Phys Med Biol 57:6929-46. 2012
    ....
  17. pmc U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female rats
    Hilda Ahnstedt
    Division of Experimental Vascular Research, Department of Clinical Sciences, Lund University, Lund, Sweden
    J Cereb Blood Flow Metab 35:454-60. 2015
    ..In conclusion, early prevention of the ERK1/2 activation and ETB receptor-mediated vasoconstriction in the cerebral vasculature after ischemic stroke in female rats improves the long-term neurologic outcome. ..
  18. ncbi request reprint Cerebral vasoconstriction after subarachnoid hemorrhage--role of changes in vascular receptor phenotype
    Jacob Hansen-Schwartz
    Dept of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Front Biosci 13:2160-4. 2008
    ....
  19. pmc Androgenic/estrogenic balance in the male rat cerebral circulation: metabolic enzymes and sex steroid receptors
    Rayna J Gonzales
    Department of Pharmacology, School of Medicine, University of California, Irvine, CA, USA
    J Cereb Blood Flow Metab 27:1841-52. 2007
    ..Furthermore, local metabolism of testosterone might balance opposing androgenic and estrogenic influences on cerebrovascular as well as brain function in males...