N Rubio

Summary

Country: Spain

Publications

  1. request reprint
    Rubio N, Torres C. Interferon-gamma induces proliferation but not apoptosis in murine astrocytes through the differential expression of the myc proto-oncogene family. Brain Res Mol Brain Res. 1999;71:104-10 pubmed
    ..Conversely, treatment with a dose of 10 U/ml induced cells proliferation in astrocytic cells as measured by (3)H-thymidine incorporation. ..
  2. request reprint
    Rubio N, Martìn Clemente B. Binding of adenovirus to its receptors in mouse astrocytes induces c-fos proto-oncogene and apoptosis. Virology. 2002;297:211-9 pubmed
    ..The purpose of our study was to ascertain the potential for adenovirus as a gene therapy vector for neural disorders caused by astrocyte dysfunctions. ..
  3. request reprint
    Rubio N, Rodriguez R, Arevalo M. In vitro myelination by oligodendrocyte precursor cells transfected with the neurotrophin-3 gene. Glia. 2004;47:78-87 pubmed
    ..We discuss the future use of this transfected cells in regeneration and functional recovery in experimental models of multiple sclerosis. ..
  4. request reprint
    Rubio N, Sanz Rodriguez F, Lipton H. Theiler's virus induces the MIP-2 chemokine (CXCL2) in astrocytes from genetically susceptible but not from resistant mouse strains. Cell Immunol. 2006;239:31-40 pubmed
    ..This suggest an role for this chemokine in attracting immune cells within the CNS, which in turn, might trigger demyelination in this experimental model of MS. ..
  5. Rubio N, Palomo M, Alcami A. Interferon-alpha/beta genes are up-regulated in murine brain astrocytes after infection with Theiler's murine encephalomyelitis virus. J Interferon Cytokine Res. 2010;30:253-62 pubmed publisher
    ..The brains of infected mice contained IFN-alpha/beta mRNA during the acute encephalitis phase, peaking at day 5 post-infection. Our findings could have significance for human diseases such as viral encephalitis and multiple sclerosis. ..
  6. Rubio N, Sanz Rodriguez F, Arevalo M. Up-regulation of the vascular cell adhesion molecule-1 (VCAM-1) induced by Theiler's murine encephalomyelitis virus infection of murine brain astrocytes. Cell Commun Adhes. 2010;17:57-68 pubmed publisher
    ..The present data show a small but statistically significant overexpression of VCAM-1 after astrocyte infection with TMEV that could play a significant role in vivo...
  7. Rubio N, Garcia Segura L, Arevalo M. Survivin prevents apoptosis by binding to caspase-3 in astrocytes infected with the BeAn strain of Theiler's murine encephalomyelitis virus. J Neurovirol. 2012;18:354-63 pubmed publisher
    ..The present results suggest that astrocytes infected by the BeAn strain do not undergo apoptosis due to the production of survivin. ..

Collaborators

Detail Information

Publications7

  1. request reprint
    Rubio N, Torres C. Interferon-gamma induces proliferation but not apoptosis in murine astrocytes through the differential expression of the myc proto-oncogene family. Brain Res Mol Brain Res. 1999;71:104-10 pubmed
    ..Conversely, treatment with a dose of 10 U/ml induced cells proliferation in astrocytic cells as measured by (3)H-thymidine incorporation. ..
  2. request reprint
    Rubio N, Martìn Clemente B. Binding of adenovirus to its receptors in mouse astrocytes induces c-fos proto-oncogene and apoptosis. Virology. 2002;297:211-9 pubmed
    ..The purpose of our study was to ascertain the potential for adenovirus as a gene therapy vector for neural disorders caused by astrocyte dysfunctions. ..
  3. request reprint
    Rubio N, Rodriguez R, Arevalo M. In vitro myelination by oligodendrocyte precursor cells transfected with the neurotrophin-3 gene. Glia. 2004;47:78-87 pubmed
    ..We discuss the future use of this transfected cells in regeneration and functional recovery in experimental models of multiple sclerosis. ..
  4. request reprint
    Rubio N, Sanz Rodriguez F, Lipton H. Theiler's virus induces the MIP-2 chemokine (CXCL2) in astrocytes from genetically susceptible but not from resistant mouse strains. Cell Immunol. 2006;239:31-40 pubmed
    ..This suggest an role for this chemokine in attracting immune cells within the CNS, which in turn, might trigger demyelination in this experimental model of MS. ..
  5. Rubio N, Palomo M, Alcami A. Interferon-alpha/beta genes are up-regulated in murine brain astrocytes after infection with Theiler's murine encephalomyelitis virus. J Interferon Cytokine Res. 2010;30:253-62 pubmed publisher
    ..The brains of infected mice contained IFN-alpha/beta mRNA during the acute encephalitis phase, peaking at day 5 post-infection. Our findings could have significance for human diseases such as viral encephalitis and multiple sclerosis. ..
  6. Rubio N, Sanz Rodriguez F, Arevalo M. Up-regulation of the vascular cell adhesion molecule-1 (VCAM-1) induced by Theiler's murine encephalomyelitis virus infection of murine brain astrocytes. Cell Commun Adhes. 2010;17:57-68 pubmed publisher
    ..The present data show a small but statistically significant overexpression of VCAM-1 after astrocyte infection with TMEV that could play a significant role in vivo...
  7. Rubio N, Garcia Segura L, Arevalo M. Survivin prevents apoptosis by binding to caspase-3 in astrocytes infected with the BeAn strain of Theiler's murine encephalomyelitis virus. J Neurovirol. 2012;18:354-63 pubmed publisher
    ..The present results suggest that astrocytes infected by the BeAn strain do not undergo apoptosis due to the production of survivin. ..