N Rubio


Country: Spain


  1. Rubio N, Arevalo M, Cerciat M, Sanz Rodriguez F, Unkila M, Garcia Segura L. Theiler's virus infection provokes the overexpression of genes coding for the chemokine Ip10 (CXCL10) in SJL/J murine astrocytes, which can be inhibited by modulators of estrogen receptors. J Neurovirol. 2014;20:485-95 pubmed publisher
    ..Finally, this in vitro inflammation model was fully inhibited by 17?-estradiol and four selective estrogen receptor modulators, as demonstrated by ELISA and qPCR. ..
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    Rubio N, Gonzalez Tirante M, Arevalo M, Aranguez I. Over-expression of GTP-binding proteins and GTPase activity in mouse astrocyte membranes in response to Theiler's murine encephalomyelitis virus infection. J Neurochem. 2008;104:100-12 pubmed
    ..Here we demonstrate that one of the mechanisms triggered by TMEV infection of astrocytes is the up-regulation of proteins related to GTP metabolism, one important signal transduction system in mammalian cells. ..
  3. Rubio N, Cerciat M, Unkila M, Garcia Segura L, Arevalo M. An in vitro experimental model of neuroinflammation: the induction of interleukin-6 in murine astrocytes infected with Theiler's murine encephalomyelitis virus, and its inhibition by oestrogenic receptor modulators. Immunology. 2011;133:360-9 pubmed publisher
    ..Finally, this in vitro neuroinflammation model was fully inhibited, as demonstrated by ELISA and qPCR, by five selective oestrogen receptor modulators. ..
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    Rubio N, Sanz Rodriguez F. Induction of the CXCL1 (KC) chemokine in mouse astrocytes by infection with the murine encephalomyelitis virus of Theiler. Virology. 2007;358:98-108 pubmed
    ..As no CXCL1 induction can be detected neither in cultured BALB/c astrocytes nor in nervous tissue, we propose an important role for CXCL1 in this experimental model of multiple sclerosis as a chemoattractant of destructive immune cells. ..
  5. Rubio N, Sanz Rodriguez F. Overexpression of caspase 1 in apoptosis-resistant astrocytes infected with the BeAn Theiler's virus. J Neurovirol. 2016;22:316-26 pubmed publisher
    ..The direct experimental evidence that the protection effect demonstrated in this article was mediated by caspase 1, is provided by the fact that its specific inhibitor Z-WEHD-FMK induced de novo apoptotic death. ..
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    Rubio N, Torres C. Interferon-gamma induces proliferation but not apoptosis in murine astrocytes through the differential expression of the myc proto-oncogene family. Brain Res Mol Brain Res. 1999;71:104-10 pubmed
    ..Conversely, treatment with a dose of 10 U/ml induced cells proliferation in astrocytic cells as measured by (3)H-thymidine incorporation. ..
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    Rubio N, Mart├Čn Clemente B. Binding of adenovirus to its receptors in mouse astrocytes induces c-fos proto-oncogene and apoptosis. Virology. 2002;297:211-9 pubmed
    ..The purpose of our study was to ascertain the potential for adenovirus as a gene therapy vector for neural disorders caused by astrocyte dysfunctions. ..
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    Rubio N, Rodriguez R, Arevalo M. In vitro myelination by oligodendrocyte precursor cells transfected with the neurotrophin-3 gene. Glia. 2004;47:78-87 pubmed
    ..We discuss the future use of this transfected cells in regeneration and functional recovery in experimental models of multiple sclerosis. ..
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    Rubio N, Sanz Rodriguez F, Lipton H. Theiler's virus induces the MIP-2 chemokine (CXCL2) in astrocytes from genetically susceptible but not from resistant mouse strains. Cell Immunol. 2006;239:31-40 pubmed
    ..This suggest an role for this chemokine in attracting immune cells within the CNS, which in turn, might trigger demyelination in this experimental model of MS. ..

More Information


  1. Rubio N, Palomo M, Alcami A. Interferon-alpha/beta genes are up-regulated in murine brain astrocytes after infection with Theiler's murine encephalomyelitis virus. J Interferon Cytokine Res. 2010;30:253-62 pubmed publisher
    ..The brains of infected mice contained IFN-alpha/beta mRNA during the acute encephalitis phase, peaking at day 5 post-infection. Our findings could have significance for human diseases such as viral encephalitis and multiple sclerosis. ..
  2. Rubio N, Sanz Rodriguez F, Arevalo M. Up-regulation of the vascular cell adhesion molecule-1 (VCAM-1) induced by Theiler's murine encephalomyelitis virus infection of murine brain astrocytes. Cell Commun Adhes. 2010;17:57-68 pubmed publisher
    ..The present data show a small but statistically significant overexpression of VCAM-1 after astrocyte infection with TMEV that could play a significant role in vivo...
  3. Rubio N, Garcia Segura L, Arevalo M. Survivin prevents apoptosis by binding to caspase-3 in astrocytes infected with the BeAn strain of Theiler's murine encephalomyelitis virus. J Neurovirol. 2012;18:354-63 pubmed publisher
    ..The present results suggest that astrocytes infected by the BeAn strain do not undergo apoptosis due to the production of survivin. ..