N Rubio

Summary

Country: Spain

Publications

  1. doi request reprint Overexpression of caspase 1 in apoptosis-resistant astrocytes infected with the BeAn Theiler's virus
    Nazario Rubio
    Instituto Cajal C S I C, Dr Arce Avenue 37, 28002, Madrid, Spain
    J Neurovirol 22:316-26. 2016
  2. doi request reprint Theiler's virus infection provokes the overexpression of genes coding for the chemokine Ip10 (CXCL10) in SJL/J murine astrocytes, which can be inhibited by modulators of estrogen receptors
    Nazario Rubio
    Instituto Cajal, C S I C, Doctor Arce Avenue 37, 28002, Madrid, Spain
    J Neurovirol 20:485-95. 2014
  3. doi request reprint Survivin prevents apoptosis by binding to caspase-3 in astrocytes infected with the BeAn strain of Theiler's murine encephalomyelitis virus
    Nazario Rubio
    Instituto Cajal, CSIC, 28002 Madrid, Spain
    J Neurovirol 18:354-63. 2012
  4. ncbi request reprint High-neurovirulence GDVII virus induces apoptosis in murine astrocytes through tumor necrosis factor (TNF)-receptor and TNF-related apoptosis-inducing ligand
    Nazario Rubio
    Instituto Cajal, C S I C, Madrid, 28002 Spain
    Virology 311:366-75. 2003
  5. ncbi request reprint In vitro myelination by oligodendrocyte precursor cells transfected with the neurotrophin-3 gene
    Nazario Rubio
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    Glia 47:78-87. 2004
  6. ncbi request reprint Theiler's virus induces the MIP-2 chemokine (CXCL2) in astrocytes from genetically susceptible but not from resistant mouse strains
    Nazario Rubio
    Instituto Cajal, C S I C, Madrid, Spain
    Cell Immunol 239:31-40. 2006
  7. ncbi request reprint Induction of the CXCL1 (KC) chemokine in mouse astrocytes by infection with the murine encephalomyelitis virus of Theiler
    Nazario Rubio
    Instituto Cajal, C S I C, Dr Arce Avenue 37, 28002 Madrid, Spain
    Virology 358:98-108. 2007
  8. ncbi request reprint Over-expression of GTP-binding proteins and GTPase activity in mouse astrocyte membranes in response to Theiler's murine encephalomyelitis virus infection
    Nazario Rubio
    Instituto Cajal, C S I C, Madrid, Spain
    J Neurochem 104:100-12. 2008
  9. doi request reprint Interferon-alpha/beta genes are up-regulated in murine brain astrocytes after infection with Theiler's murine encephalomyelitis virus
    Nazario Rubio
    Instituto Cajal, CSIC, Madrid, Spain
    J Interferon Cytokine Res 30:253-62. 2010
  10. doi request reprint Up-regulation of the vascular cell adhesion molecule-1 (VCAM-1) induced by Theiler's murine encephalomyelitis virus infection of murine brain astrocytes
    Nazario Rubio
    Instituto Cajal, C S I C, Madrid, Spain
    Cell Commun Adhes 17:57-68. 2010

Detail Information

Publications26

  1. doi request reprint Overexpression of caspase 1 in apoptosis-resistant astrocytes infected with the BeAn Theiler's virus
    Nazario Rubio
    Instituto Cajal C S I C, Dr Arce Avenue 37, 28002, Madrid, Spain
    J Neurovirol 22:316-26. 2016
    ..The direct experimental evidence that the protection effect demonstrated in this article was mediated by caspase 1, is provided by the fact that its specific inhibitor Z-WEHD-FMK induced de novo apoptotic death. ..
  2. doi request reprint Theiler's virus infection provokes the overexpression of genes coding for the chemokine Ip10 (CXCL10) in SJL/J murine astrocytes, which can be inhibited by modulators of estrogen receptors
    Nazario Rubio
    Instituto Cajal, C S I C, Doctor Arce Avenue 37, 28002, Madrid, Spain
    J Neurovirol 20:485-95. 2014
    ..Finally, this in vitro inflammation model was fully inhibited by 17β-estradiol and four selective estrogen receptor modulators, as demonstrated by ELISA and qPCR...
  3. doi request reprint Survivin prevents apoptosis by binding to caspase-3 in astrocytes infected with the BeAn strain of Theiler's murine encephalomyelitis virus
    Nazario Rubio
    Instituto Cajal, CSIC, 28002 Madrid, Spain
    J Neurovirol 18:354-63. 2012
    ..The present results suggest that astrocytes infected by the BeAn strain do not undergo apoptosis due to the production of survivin...
  4. ncbi request reprint High-neurovirulence GDVII virus induces apoptosis in murine astrocytes through tumor necrosis factor (TNF)-receptor and TNF-related apoptosis-inducing ligand
    Nazario Rubio
    Instituto Cajal, C S I C, Madrid, 28002 Spain
    Virology 311:366-75. 2003
    ..Conversely, many of the apoptotic cells found were also positive for GFAP staining...
  5. ncbi request reprint In vitro myelination by oligodendrocyte precursor cells transfected with the neurotrophin-3 gene
    Nazario Rubio
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    Glia 47:78-87. 2004
    ..We discuss the future use of this transfected cells in regeneration and functional recovery in experimental models of multiple sclerosis...
  6. ncbi request reprint Theiler's virus induces the MIP-2 chemokine (CXCL2) in astrocytes from genetically susceptible but not from resistant mouse strains
    Nazario Rubio
    Instituto Cajal, C S I C, Madrid, Spain
    Cell Immunol 239:31-40. 2006
    ..This suggest an role for this chemokine in attracting immune cells within the CNS, which in turn, might trigger demyelination in this experimental model of MS...
  7. ncbi request reprint Induction of the CXCL1 (KC) chemokine in mouse astrocytes by infection with the murine encephalomyelitis virus of Theiler
    Nazario Rubio
    Instituto Cajal, C S I C, Dr Arce Avenue 37, 28002 Madrid, Spain
    Virology 358:98-108. 2007
    ..As no CXCL1 induction can be detected neither in cultured BALB/c astrocytes nor in nervous tissue, we propose an important role for CXCL1 in this experimental model of multiple sclerosis as a chemoattractant of destructive immune cells...
  8. ncbi request reprint Over-expression of GTP-binding proteins and GTPase activity in mouse astrocyte membranes in response to Theiler's murine encephalomyelitis virus infection
    Nazario Rubio
    Instituto Cajal, C S I C, Madrid, Spain
    J Neurochem 104:100-12. 2008
    ..Here we demonstrate that one of the mechanisms triggered by TMEV infection of astrocytes is the up-regulation of proteins related to GTP metabolism, one important signal transduction system in mammalian cells...
  9. doi request reprint Interferon-alpha/beta genes are up-regulated in murine brain astrocytes after infection with Theiler's murine encephalomyelitis virus
    Nazario Rubio
    Instituto Cajal, CSIC, Madrid, Spain
    J Interferon Cytokine Res 30:253-62. 2010
    ..The brains of infected mice contained IFN-alpha/beta mRNA during the acute encephalitis phase, peaking at day 5 post-infection. Our findings could have significance for human diseases such as viral encephalitis and multiple sclerosis...
  10. doi request reprint Up-regulation of the vascular cell adhesion molecule-1 (VCAM-1) induced by Theiler's murine encephalomyelitis virus infection of murine brain astrocytes
    Nazario Rubio
    Instituto Cajal, C S I C, Madrid, Spain
    Cell Commun Adhes 17:57-68. 2010
    ..The present data show a small but statistically significant overexpression of VCAM-1 after astrocyte infection with TMEV that could play a significant role in vivo...
  11. pmc An in vitro experimental model of neuroinflammation: the induction of interleukin-6 in murine astrocytes infected with Theiler's murine encephalomyelitis virus, and its inhibition by oestrogenic receptor modulators
    Nazario Rubio
    Instituto Cajal C S I C, Madrid, Spain
    Immunology 133:360-9. 2011
    ..Finally, this in vitro neuroinflammation model was fully inhibited, as demonstrated by ELISA and qPCR, by five selective oestrogen receptor modulators...
  12. ncbi request reprint Binding of adenovirus to its receptors in mouse astrocytes induces c-fos proto-oncogene and apoptosis
    Nazario Rubio
    Department of Neuroimmunology, Instituto Cajal, C S I C, Dr Arce Avenue 37, Madrid, Spain
    Virology 297:211-9. 2002
    ..The purpose of our study was to ascertain the potential for adenovirus as a gene therapy vector for neural disorders caused by astrocyte dysfunctions...
  13. ncbi request reprint Interferon-gamma protects astrocytes from apoptosis and increases the formation of p21ras-GTP complex through ras oncogene family overexpression
    N Rubio
    Department of Neuroimmunology, Instituto Cajal, C S I C, Dr Arce Avenue 37, 28002 Madrid, Spain
    Glia 33:151-9. 2001
    ..We propose that those effects are mediated through ras oncogene family everexpression...
  14. ncbi request reprint Interferon-gamma induces proliferation but not apoptosis in murine astrocytes through the differential expression of the myc proto-oncogene family
    N Rubio
    Department of Neuroimmunology, Instituto Cajal, CSIC, Dr Arce Avenue 37, 28002, Madrid, Spain
    Brain Res Mol Brain Res 71:104-10. 1999
    ..Conversely, treatment with a dose of 10 U/ml induced cells proliferation in astrocytic cells as measured by (3)H-thymidine incorporation...
  15. ncbi request reprint Theiler's murine encephalomyelitis virus infection induces early expression of c-fos in astrocytes
    N Rubio
    Department of Neuroimmunology, Instituto Cajal, C S I C, Madrid, Spain
    Virology 258:21-9. 1999
    ..The biological relevance of these findings is assessed by the demonstration of c-fos activation after viral infection in vivo...
  16. ncbi request reprint Adenovirus vector-directed expression of the neurotrophin-3 receptor (TrkC) in mouse astrocytes
    N Rubio
    Department of Neuroimmunology, Instituto Cajal, Madrid, Spain
    J Neurovirol 7:72-81. 2001
    ..These results demonstrate that our AdTrkC vector efficiently mediates the expression of high-levels of biologically active NT-3 receptors...
  17. ncbi request reprint Theiler's murine encephalomyelitis virus-binding activity on neural and non-neural cell lines and tissues
    N Rubio
    Department of Neuroimmunology, Instituto Cajal, Madrid, Spain
    J Gen Virol 71:2867-72. 1990
    ..The number of virus-binding sites in the BHK-21 cell line is reported here to be 5 x 10(3) per cell; approximately 15 x 10(3) and 2.5 x 10(3) are the estimates of binding sites per cultured neuron and macroglial cell, respectively...
  18. pmc Receptors for Theiler's murine encephalomyelitis virus: characterization by using rabbit antiviral antiserum
    N Rubio
    Instituto Cajal, Madrid, Spain
    J Virol 62:4303-6. 1988
    ..Cell surface receptors were still active after fixation, and only intact viruses were bound, as demonstrated by the lack of binding of the purified, isolated virion proteins VP1, VP2, and VP3...
  19. ncbi request reprint Differential IL-1 synthesis by astrocytes from Theiler's murine encephalomyelitis virus-susceptible and -resistant strains of mice
    N Rubio
    Department of Neuroimmunology, Instituto Cajal, Madrid, Spain
    Cell Immunol 149:237-47. 1993
    ....
  20. ncbi request reprint Lack of cross-reaction between myelin basic proteins and putative demyelinating virus envelope proteins
    N Rubio
    Instituto Cajal, Department of Neuroimmunology, Velazquez, Madrid, Spain
    Mol Immunol 26:663-8. 1989
    ..In the human situation, antibodies against SV5 and measles viruses, both etiologically linked with multiple sclerosis, also failed to recognize MBP. These results rule out molecular mimicry as a cause of demyelination...
  21. pmc Theiler's murine encephalomyelitis virus induces tumour necrosis factor-alpha in murine astrocyte cell cultures
    A Sierra
    Instituto Cajal, Department of Neuroimmunology, Madrid, Spain
    Immunology 78:399-404. 1993
    ..These results indicate an active role for astrocytes as accessory immune cells in our experimental model for multiple sclerosis...
  22. pmc Demonstration of the presence of an interleukin-1 receptor on the surface of murine astrocytes and its regulation by cytokines and Theiler's virus
    N Rubio
    Department of Neuroimmunology, Instituto Cajal, Madrid, Spain
    Immunology 82:178-83. 1994
    ..The receptor expression was up-regulated by Theiler's virus, interferon-gamma, tumour necrosis factor and IL-6; was not affected by vaccinia virus infection; and decreased after lipopolysaccharide treatment...
  23. ncbi request reprint Characterization of the immune response to intracerebral inoculation of Theiler's murine encephalomyelitis virus: fine protein specificity of the splenic T cell and humoral antibody response
    A K Scheu
    Department of Neuroimmunology, Instituto Cajal, Madrid, Spain
    Immunol Lett 21:171-6. 1989
    ..The antibody synthesis showed the same antigenic specificity as the cellular one, as only antibodies against VP1 and VP2 could be found in the sera of the immunized animals...
  24. pmc IL-1, IL-2 and IFN-gamma production by Theiler's virus-induced encephalomyelitic SJL/J mice
    N Rubio
    Department of Neuroimmunology, Instituto Cajal, Madrid, Spain
    Immunology 74:284-9. 1991
    ..In addition, we propose a central role for IL-1 in augmenting the intracerebral immune response leading to the inflammatory demyelination induced by TMEV...
  25. doi request reprint Upregulation of voltage-gated Ca2+ channels in mouse astrocytes infected with Theiler's murine encephalomyelitis virus (TMEV)
    N Rubio
    Instituto Cajal, CSIC, Madrid, Spain
    Neuroscience 247:309-18. 2013
    ....
  26. ncbi request reprint Characterization of the specific meningeal T cell response to intracerebral inoculation of Theiler's murine encephalomyelitis virus
    A K Scheu
    Department of Neuroimmunology, Instituto Cajal, Madrid, Spain
    J Neuroimmunol 31:229-34. 1991
    ..This response indicated that leptomeningeal mononuclear cell infiltrations are involved in the immune response that triggers the demyelinating disease...