- González Ordóñez A, Fernández Carreira J, Medina Rodriguez J, Martín Sánchez L, Alvarez Díaz R, Alvarez Martinez M, et al. Risk of venous thromboembolism associated with the insertion/deletion polymorphism in the angiotensin-converting enzyme gene. Blood Coagul Fibrinolysis. 2000;11:485-90 pubmed..In conclusion, among (Spanish) Caucasians, this study does not support the hypothesis that the deletion allele (D) of the ACE gene could be a significant risk factor for VTE, being protective in men. ..