Louis Tong

Summary

Grants:

Publications

  1. ncbi Heidelberg retinal tomography of optic disc and nerve fiber layer in singapore children: variations with disc tilt and refractive error
    Louis Tong
    Singapore National Eye Center, Singapore
    Invest Ophthalmol Vis Sci 48:4939-44. 2007
  2. ncbi Aspirin and dry eye?
    Louis Tong
    Ophthalmology 116:167-167.e1. 2009
  3. doi Direct costs of myopia in Singapore
    M C C Lim
    Department of Ophthalmology, Singapore National Eye Centre, Singapore, Singapore
    Eye (Lond) 23:1086-9. 2009
  4. doi Corneal biomechanics, thickness and optic disc morphology in children with optic disc tilt
    L Lim
    Singapore Eye Research Institute, Singapore
    Br J Ophthalmol 92:1461-6. 2008
  5. ncbi Red-green colour blindness in Singaporean children
    Audrey Chia
    Singapore Eye Research Institute, Singapore
    Clin Exp Ophthalmol 36:464-7. 2008
  6. pmc Calcium-binding S100 protein expression in pterygium
    Andri K Riau
    Singapore Eye Research Institute, Singapore
    Mol Vis 15:335-42. 2009
  7. doi Distribution and determinants of ocular biometric parameters in an Asian population: the Singapore Malay eye study
    Laurence Shen Lim
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 51:103-9. 2010
  8. pmc Intra-observer and inter-observer repeatability of ocular surface interferometer in measuring lipid layer thickness
    Yang Zhao
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    BMC Ophthalmol 15:53. 2015
  9. ncbi Refractive error and monochromatic aberrations in Singaporean children
    Andrew Carkeet
    Singapore National Eye Centre, Singapore Eye Research Institute, Level 6, 11 Third Hospital Avenue, 168751 Singapore
    Vision Res 42:1809-24. 2002
  10. ncbi Corneal thickness determination and correlates in Singaporean schoolchildren
    Louis Tong
    Singapore National Eye Center, Singapore
    Invest Ophthalmol Vis Sci 45:4004-9. 2004

Collaborators

Detail Information

Publications42

  1. ncbi Heidelberg retinal tomography of optic disc and nerve fiber layer in singapore children: variations with disc tilt and refractive error
    Louis Tong
    Singapore National Eye Center, Singapore
    Invest Ophthalmol Vis Sci 48:4939-44. 2007
    ....
  2. ncbi Aspirin and dry eye?
    Louis Tong
    Ophthalmology 116:167-167.e1. 2009
  3. doi Direct costs of myopia in Singapore
    M C C Lim
    Department of Ophthalmology, Singapore National Eye Centre, Singapore, Singapore
    Eye (Lond) 23:1086-9. 2009
    ..To estimate the direct costs of myopia in Singapore children...
  4. doi Corneal biomechanics, thickness and optic disc morphology in children with optic disc tilt
    L Lim
    Singapore Eye Research Institute, Singapore
    Br J Ophthalmol 92:1461-6. 2008
    ....
  5. ncbi Red-green colour blindness in Singaporean children
    Audrey Chia
    Singapore Eye Research Institute, Singapore
    Clin Exp Ophthalmol 36:464-7. 2008
    ..Various studies suggest that, worldwide, 2-8% of men are afflicted with this condition. The purpose of this study is to determine the prevalence of red-green colour blindness in Singaporean schoolchildren...
  6. pmc Calcium-binding S100 protein expression in pterygium
    Andri K Riau
    Singapore Eye Research Institute, Singapore
    Mol Vis 15:335-42. 2009
    ..The aim of this study was to investigate the presence of various S100 proteins in pterygium compared to normal conjunctiva...
  7. doi Distribution and determinants of ocular biometric parameters in an Asian population: the Singapore Malay eye study
    Laurence Shen Lim
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 51:103-9. 2010
    ..To examine the distribution and systemic determinants of ocular biometry as measured using partial laser interferometry in an adult Asian population...
  8. pmc Intra-observer and inter-observer repeatability of ocular surface interferometer in measuring lipid layer thickness
    Yang Zhao
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    BMC Ophthalmol 15:53. 2015
    ..Recently, there have been clinical studies using interferometry to assess lipid layer thickness (LLT). The aim of the study is to examine the repeatability of a commercially available interferometer...
  9. ncbi Refractive error and monochromatic aberrations in Singaporean children
    Andrew Carkeet
    Singapore National Eye Centre, Singapore Eye Research Institute, Level 6, 11 Third Hospital Avenue, 168751 Singapore
    Vision Res 42:1809-24. 2002
    ..e. of posterior cornea and crystalline lens) did vary significantly with refractive error and race. Our results do not provide any evidence for aberration-driven form-deprivation as a major mechanism of myopia development...
  10. ncbi Corneal thickness determination and correlates in Singaporean schoolchildren
    Louis Tong
    Singapore National Eye Center, Singapore
    Invest Ophthalmol Vis Sci 45:4004-9. 2004
    ..To determine the central cornea thickness (CCT) in Singaporean children and to examine the possible relationship between intraocular pressure (IOP) and other biometric factors and CCT...
  11. ncbi Screening for myopia and refractive errors using LogMAR visual acuity by optometrists and a simplified visual acuity chart by nurses
    Louis Tong
    Singapore National Eye Center, Singapore
    Optom Vis Sci 81:684-91. 2004
    ..A secondary aim is to estimate the best cutoff values for the detection of refractive errors using these two methods...
  12. doi A questionnaire-based assessment of symptoms associated with tear film dysfunction and lid margin disease in an Asian population
    Louis Tong
    Singapore National Eye Center, Singapore
    Ophthalmic Epidemiol 16:31-7. 2009
    ..To study the prevalence, associated factors and impact of symptomatic dry eye in an Asian population...
  13. doi Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics
    Lei Zhou
    Singapore Eye Research Institute, Singapore, Singapore
    J Proteome Res 8:4889-905. 2009
    ..This study demonstrated that iTRAQ technology combined with 2D-nanoLC-nanoESI-MS/MS quantitative proteomics is a powerful tool for biomarker discovery...
  14. ncbi Anisometropia in Singapore school children
    Louis Tong
    Singapore National Eye Center, Singapore, Singapore
    Am J Ophthalmol 137:474-9. 2004
    ..To report the prevalence rates of anisometropia in a school population and determine the relative contribution of refractive power and axial length to the measured anisometropia...
  15. doi Practical issues concerning tear protein assays in dry eye.
    Sharon D Souza
    Narayana Nethralaya Superspeciality Eye Hospital and Post Graduate Institute, Bangalore, Karnataka India
    Eye Vis (Lond) 1:6. 2014
    ..Much remains to be done in terms of developing office-based assays and ascertaining their reliability, but current evidence suggests that tear proteins have a role in the clinical practice of dry eye...
  16. doi Toll-like receptor 2-mediated NF-kappa B pathway activation in ocular surface epithelial cells
    Aihua Hou
    Ocular Surface Research Group, Singapore Eye Research Institute, Singapore, Singapore
    Eye Vis (Lond) 4:17. 2017
    ..This study aims to establish an in-vitro cell culture system to assess NF-κB activation in the context of ocular surface cells...
  17. doi Coping with dry eyes: a qualitative approach.
    Sharon Yeo
    Ocular Surface Research Group, Singapore Eye Research Institute, Singapore, Singapore
    BMC Ophthalmol 18:8. 2018
    ..Holistic coping strategies were found to be prominent in dry eye sufferers from these focus groups, and people tend to find personalised ways of coping with the impact of dry eye on daily living...
  18. pmc Distinct gene subsets in pterygia formation and recurrence: dissecting complex biological phenomenon using genome wide expression data
    Louis Tong
    Singapore Eye Research Institute SERI, Singapore National Eye Center, Singapore
    BMC Med Genomics 2:14. 2009
    ..However, the mechanisms for formation and post-surgical recurrence of pterygium are not understood, and a valid animal model does not exist. Here, we investigated the possible mechanisms of pterygium pathogenesis and recurrence...
  19. doi Effects of Punctal Occlusion on Clinical Signs and Symptoms and on Tear Cytokine Levels in Patients with Dry Eye
    Louis Tong
    Singapore Eye Research Institute, National Eye Centre, Singapore, Singapore Yong Loo Lin School of Medicine, Singapore, Singapore Singapore National Eye Center, Singapore, Singapore Duke NUS Medical School, Singapore, Singapore Electronic address
    Ocul Surf 14:233-41. 2016
    ..To investigate changes in signs, symptoms, and tear cytokines following punctal plug occlusion in patients with dry eye...
  20. pmc Rho GTPases and regulation of cell migration and polarization in human corneal epithelial cells
    Aihua Hou
    Ocular Surface Research Group, Singapore Eye Research Institute, Singapore, Singapore, Singapore
    PLoS ONE 8:e77107. 2013
    ..This study aimed to determine the expression pattern of Rho family small G-proteins in human corneal epithelial cells to test their requirement in directional cell migration...
  21. pmc Knowledge, attitude, and practice of dry eye treatment by institutional Chinese physicians in Singapore
    Wanwen Lan
    Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751
    ScientificWorldJournal 2012:923059. 2012
    ..The majority of surveyed institutional TCM practitioners in Singapore believe that TCM is relevant in dry eye treatment. Public awareness should be raised regarding the availability of TCM as alternative medicine for dry eye...
  22. doi S100A proteins as molecular targets in the ocular surface inflammatory diseases
    Louis Tong
    Ocular Surface Research Group, Singapore Eye Research Institute, Singapore Department of Cornea and External Eye Disease, Singapore National Eye Center, Singapore Office of Clinical Science, Duke NUS Graduate Medical School, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Electronic address
    Ocul Surf 12:23-31. 2014
    ..Injection of S100A8 has been shown to inhibit eosinophilic infiltration and thus may have potential therapeutic implications in allergic diseases. ..
  23. doi Conjunctivochalasis is the precursor to pterygium
    Louis Tong
    Ocular Surface Research Group, Singapore Eye Research Institute, Singapore Department of Cornea and External Eye Disease, Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751, Singapore Office of Clinical Science, Duke NUS Graduate Medical School, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Electronic address
    Med Hypotheses 81:927-30. 2013
    ..Second, during resection of pterygium, it may not be necessary to resect the pterygium too extensively away from the cornea, since this effectively removes relatively normal conjunctiva. ..
  24. doi Molecular mechanism of transglutaminase-2 in corneal epithelial migration and adhesion
    Louis Tong
    Ocular Surface Research Group, Singapore Eye Research Institute, Singapore
    Biochim Biophys Acta 1833:1304-15. 2013
    ..2008) [18]. TG-2 dependent β-3 integrin activation, serine-phosphorylation of paxillin, and Rac and CDC42 activation may thus play a key functional role in enhancing corneal epithelial cell adhesion and migration during wound healing...
  25. doi Choice of artificial tear formulation for patients with dry eye: where do we start?
    Louis Tong
    Department of Cornea and External Eye Disease, Singapore National Eye Center, Singapore
    Cornea 31:S32-6. 2012
    ..Side effects of lubricants, such as burning on instillation because of mismatches of eye drop with tear acidity, are also discussed...
  26. ncbi Comparison of gene expression profiles of conjunctival cell lines with primary cultured conjunctival epithelial cells and human conjunctival tissue
    Louis Tong
    Singapore National Eye Center, Singapore
    Gene Expr 14:265-78. 2009
    ....
  27. doi Impact of symptomatic dry eye on vision-related daily activities: the Singapore Malay Eye Study
    L Tong
    Department of Ophthalmology, Singapore National Eye Center, Singapore, Singapore
    Eye (Lond) 24:1486-91. 2010
    ..To examine the impact of symptomatic dry eye on vision-related daily activities...
  28. doi Screening for meibomian gland disease: its relation to dry eye subtypes and symptoms in a tertiary referral clinic in singapore
    Louis Tong
    Singapore National Eye Center, Singapore
    Invest Ophthalmol Vis Sci 51:3449-54. 2010
    ..These findings facilitate better understanding of the meibomian gland's contribution to multifactorial dry eye syndrome, apart from routine conventional tests performed in clinics...
  29. doi Phospholipase D in the human ocular surface and in pterygium
    Louis Tong
    Singapore National Eye Center, Third Hospital Avenue, Singapore
    Cornea 27:693-8. 2008
    ..We aimed to study the presence of PLD subtypes in native ocular surface tissue and pterygium...
  30. doi Prevalence and risk factors of undercorrected refractive errors among Singaporean Malay adults: the Singapore Malay Eye Study
    Mohamad Rosman
    Singapore National Eye Center, Singapore
    Invest Ophthalmol Vis Sci 50:3621-8. 2009
    ..To describe the prevalence and the risk factors of undercorrected refractive error in an adult urban Malay population...
  31. ncbi Longitudinal study of anisometropia in Singaporean school children
    Louis Tong
    Singapore National Eye Center, National University of Singapore, Singapore
    Invest Ophthalmol Vis Sci 47:3247-52. 2006
    ....
  32. doi Atropine for the treatment of childhood myopia: effect on myopia progression after cessation of atropine
    Louis Tong
    Singapore National Eye Center, Singapore
    Ophthalmology 116:572-9. 2009
    ..The aim of this study was to assess the effect on myopia progression after cessation of topical atropine treatment...
  33. ncbi Optic disk and retinal characteristics in myopic children
    Louis Tong
    Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751
    Am J Ophthalmol 138:160-2. 2004
    ..To examine the baseline retina and optic disk characteristics in children...
  34. ncbi A multiple regression approach to study optical components of myopia in Singapore school children
    Louis Tong
    Singapore Eye Research Institute and Singapore National Eye Centre
    Ophthalmic Physiol Opt 22:32-7. 2002
    ..We perform a study to assess the association of the optical components of the eye contributing to the degree of myopia by building a statistical model which can better assess the individual effects of each optical component...
  35. ncbi Agreement between Scheimpflug photography and A-scan ultrasonography in anterior segment ocular measurements in children
    Louis Tong
    Singapore National Eye Centre, Singapore
    Optom Vis Sci 80:529-34. 2003
    ..The purpose of this study was to examine the agreement in anterior chamber length and lens thickness measurements between A-scan ultrasonography and Scheimpflug photography...
  36. ncbi Sensitivity and specificity of visual acuity screening for refractive errors in school children
    Louis Tong
    Singapore National Eye Centre, Singapore
    Optom Vis Sci 79:650-7. 2002
    ..To examine the optimal cutoff point for the use of the visual acuity test to screen for refractive errors in schoolchildren...
  37. ncbi Incidence and progression of myopia in Singaporean school children
    Seang Mei Saw
    Department of Community, Occupational and Family Medicine, National University of Singapore
    Invest Ophthalmol Vis Sci 46:51-7. 2005
    ..To determine the incidence and progression rates of myopia in young Singaporean children...
  38. pmc Expression and regulation of cornified envelope proteins in human corneal epithelium
    Louis Tong
    Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 47:1938-46. 2006
    ....
  39. ncbi Atropine for the treatment of childhood myopia
    Wei Han Chua
    Singapore National Eye Centre, Singapore
    Ophthalmology 113:2285-91. 2006
    ..To evaluate the efficacy and safety of topical atropine, a nonselective muscarinic antagonist, in slowing the progression of myopia and ocular axial elongation in Asian children...
  40. ncbi Transglutaminase participates in UVB-induced cell death pathways in human corneal epithelial cells
    Louis Tong
    Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 47:4295-301. 2006
    ..This study evaluates the role of transglutaminase in regulating tumor necrosis factor (TNF) receptor clustering as well as caspase activation in UVB-induced apoptosis in human corneal epithelial cells...
  41. doi Hyperosmolarity-induced cornification of human corneal epithelial cells is regulated by JNK MAPK
    Zhuo Chen
    Department of Ophthalmology, The Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 49:539-49. 2008
    ....
  42. doi Cornea biomechanical characteristics and their correlates with refractive error in Singaporean children
    Laurence Lim
    Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 49:3852-7. 2008
    ..To determine corneal biomechanical parameters measured with the Reichert Ocular Response Analyser (ORA) in Singaporean children, and to assess their possible correlations with refractive error and biometry...