JoÃ£o Pedro de MagalhÃ£es
Dayoub J, Cortese F, Anžič A, Grum T, de Magalhães J. The effects of donor age on organ transplants: A review and implications for aging research. Exp Gerontol. 2018;110:230-240 pubmed publisher
..Overall, patterns of the effect of donor age in patient and graft survival were observed for several organ types and placed in the context of knowledge on aging. ..
Tong K, Mahmood Zuhdi A, Wan Ahmad W, Vanhoutte P, de Magalhães J, Mustafa M, et al
. Circulating MicroRNAs in Young Patients with Acute Coronary Syndrome. Int J Mol Sci. 2018;19: pubmed publisher
..935) with the three miRNAs combination. Plasma miR-183-5p, miR-134-5p, miR-15a-5p and let-7i-5p are deregulated in STEMI and NSTEMI and could be potentially used to discriminate the two ACS forms. ..
Pedro de Magalhães J, Thompson L, de Lima I, Gaskill D, Li X, Thornton D, et al
. A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging. Genetics. 2018;208:1617-1630 pubmed publisher
de Magalhães J, Faragher R. Cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity. Bioessays. 2008;30:567-78 pubmed publisher
..We discuss possible mechanisms related to this hypothesis and propose experimental paradigms. ..
Cordeiro R, Stirling S, Fahy G, de MagalhÃ£es J. Insights on cryoprotectant toxicity from gene expression profiling of endothelial cells exposed to ethylene glycol. Cryobiology. 2015;71:405-12 pubmed publisher
Wood S, van Dam S, Craig T, Tacutu R, O Toole A, Merry B, et al
. Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging. Genome Biol. 2015;16:285 pubmed publisher
..This study presents extensive data on the effects of diet and aging on the cerebral cortex transcriptome, and also emphasises the importance of epigenetics and post-translational modifications in longevity and neuroprotection. ..
Holmes A, Wong S, Pulix M, Johnson K, Horton N, Thomas P, et al
. Reductions in hypothalamic Gfap expression, glial cells and ?-tanycytes in lean and hypermetabolic Gnasxl-deficient mice. Mol Brain. 2016;9:39 pubmed publisher
de Magalhães J. Paternal genome effects on aging: evidence for a role of Rasgrf1 in longevity determination?. Mech Ageing Dev. 2011;132:72-3 pubmed publisher
de Magalhães J, Curado J, Church G. Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics. 2009;25:875-81 pubmed publisher
..http://genomics.senescence.info/uarrays/signatures.html. Supplementary data are available at Bioinformatics online. ..