João Pedro de Magalhães

Summary

Publications

  1. Dayoub J, Cortese F, Anžič A, Grum T, de Magalhães J. The effects of donor age on organ transplants: A review and implications for aging research. Exp Gerontol. 2018;110:230-240 pubmed publisher
    ..Overall, patterns of the effect of donor age in patient and graft survival were observed for several organ types and placed in the context of knowledge on aging. ..
  2. Tong K, Mahmood Zuhdi A, Wan Ahmad W, Vanhoutte P, de Magalhães J, Mustafa M, et al. Circulating MicroRNAs in Young Patients with Acute Coronary Syndrome. Int J Mol Sci. 2018;19: pubmed publisher
    ..935) with the three miRNAs combination. Plasma miR-183-5p, miR-134-5p, miR-15a-5p and let-7i-5p are deregulated in STEMI and NSTEMI and could be potentially used to discriminate the two ACS forms. ..
  3. Pedro de Magalhães J, Thompson L, de Lima I, Gaskill D, Li X, Thornton D, et al. A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging. Genetics. 2018;208:1617-1630 pubmed publisher
  4. de Magalhães J, Faragher R. Cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity. Bioessays. 2008;30:567-78 pubmed publisher
    ..We discuss possible mechanisms related to this hypothesis and propose experimental paradigms. ..
  5. Cordeiro R, Stirling S, Fahy G, de Magalhães J. Insights on cryoprotectant toxicity from gene expression profiling of endothelial cells exposed to ethylene glycol. Cryobiology. 2015;71:405-12 pubmed publisher
  6. Wood S, van Dam S, Craig T, Tacutu R, O Toole A, Merry B, et al. Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging. Genome Biol. 2015;16:285 pubmed publisher
    ..This study presents extensive data on the effects of diet and aging on the cerebral cortex transcriptome, and also emphasises the importance of epigenetics and post-translational modifications in longevity and neuroprotection. ..
  7. Holmes A, Wong S, Pulix M, Johnson K, Horton N, Thomas P, et al. Reductions in hypothalamic Gfap expression, glial cells and ?-tanycytes in lean and hypermetabolic Gnasxl-deficient mice. Mol Brain. 2016;9:39 pubmed publisher
  8. de Magalhães J. Paternal genome effects on aging: evidence for a role of Rasgrf1 in longevity determination?. Mech Ageing Dev. 2011;132:72-3 pubmed publisher
  9. de Magalhães J, Curado J, Church G. Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics. 2009;25:875-81 pubmed publisher
    ..http://genomics.senescence.info/uarrays/signatures.html. Supplementary data are available at Bioinformatics online. ..

More Information

Publications21

  1. de Magalhaes J, Costa J. A database of vertebrate longevity records and their relation to other life-history traits. J Evol Biol. 2009;22:1770-4 pubmed publisher
    ..AnAge is freely available online (http://genomics.senescence.info/species/). ..
  2. de Magalhães J. Programmatic features of aging originating in development: aging mechanisms beyond molecular damage?. FASEB J. 2012;26:4821-6 pubmed publisher
    ..Overall, it appears that the genome does, indeed, contain specific instructions that drive aging in animals, a radical shift in our perception of the aging process. ..
  3. Craig T, Smelick C, Tacutu R, Wuttke D, Wood S, Stanley H, et al. The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource. Nucleic Acids Res. 2015;43:D873-8 pubmed publisher
    ..Overall, the DAA offers a new approach to systemizing ageing resources, providing a manually-curated and readily accessible source of age-related changes. ..
  4. van Dam S, Craig T, de Magalhães J. GeneFriends: a human RNA-seq-based gene and transcript co-expression database. Nucleic Acids Res. 2015;43:D1124-32 pubmed publisher
    ..GeneFriends is freely available from http://www.GeneFriends.org and can be used to quickly identify and rank candidate targets relevant to the process or disease under study. ..
  5. de Magalhães J, Stevens M, Thornton D. The Business of Anti-Aging Science. Trends Biotechnol. 2017;35:1062-1073 pubmed publisher
    ..If even one company succeeds, however, the impact will be huge. ..
  6. de Magalhães J, Passos J. Stress, cell senescence and organismal ageing. Mech Ageing Dev. 2018;170:2-9 pubmed publisher
  7. Monaco G, van Dam S, Casal Novo Ribeiro J, Larbi A, de Magalhães J. A comparison of human and mouse gene co-expression networks reveals conservation and divergence at the tissue, pathway and disease levels. BMC Evol Biol. 2015;15:259 pubmed publisher
  8. Keane M, Semeiks J, Webb A, Li Y, Quesada V, Craig T, et al. Insights into the evolution of longevity from the bowhead whale genome. Cell Rep. 2015;10:112-22 pubmed publisher
    ..Our data are made available online (http://www.bowhead-whale.org) to facilitate research in this long-lived species. ..
  9. de Magalhães J. How ageing processes influence cancer. Nat Rev Cancer. 2013;13:357-65 pubmed publisher
    ..In the emerging age of cancer, how can our growing understanding of the biology of ageing inform cancer biology? ..
  10. de Magalhães J, Wuttke D, Wood S, Plank M, Vora C. Genome-environment interactions that modulate aging: powerful targets for drug discovery. Pharmacol Rev. 2012;64:88-101 pubmed publisher
    ..Unlocking the capacity to manipulate human aging would result in unprecedented health benefits. ..
  11. de Magalhães J, Budovsky A, Lehmann G, Costa J, Li Y, Fraifeld V, et al. The Human Ageing Genomic Resources: online databases and tools for biogerontologists. Aging Cell. 2009;8:65-72 pubmed publisher
    ..Software is also available to aid researchers in the form of Perl modules to automate numerous tasks and as an SPSS script to analyse demographic mortality data. The HAGR are available online at http://genomics.senescence.info. ..
  12. van Dam S, Cordeiro R, Craig T, van Dam J, Wood S, de Magalhães J. GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases. BMC Genomics. 2012;13:535 pubmed publisher
    ..It is an intuitive online resource that will help drive experimentation. GeneFriends is available online at: http://genefriends.org/. ..