Affiliation: University of Oslo
- Ivanauskiene K, Delbarre E, McGhie J, Küntziger T, Wong L, Collas P. The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity. Genome Res. 2014;24:1584-94 pubmed publisher..3 by dedicated chaperones. Our results also suggest that telomere stability relies on mechanisms ensuring proper histone supply and routing. ..
- Shah A, Oldenburg A, Collas P. A hyper-dynamic nature of bivalent promoter states underlies coordinated developmental gene expression modules. BMC Genomics. 2014;15:1186 pubmed publisher..Our results reveal the highly dynamic nature of bivalent promoter states within the adipogenic lineage. The data constitute a valuable resource enabling the assessment of possibilities to alter the adipogenic program. ..
- Collas P. The current state of chromatin immunoprecipitation. Mol Biotechnol. 2010;45:87-100 pubmed publisher..This review highlights the variations on the theme of the ChIP assay, the various detection methods applied downstream of ChIP, and examples of their application. ..
- Collas P. Programming differentiation potential in mesenchymal stem cells. Epigenetics. 2010;5:476-82 pubmed publisher..Additional regulatory layers need to be examined to be able to explain cell fate commitment and ultimately predict cell fate. ..
- Aanes H, Østrup O, Andersen I, Moen L, Mathavan S, Collas P, et al. Differential transcript isoform usage pre- and post-zygotic genome activation in zebrafish. BMC Genomics. 2013;14:331 pubmed publisher..Our data display an array of isoform-related functional changes and represent a valuable resource complementary to existing early embryo transcriptomes. ..
- Ostrup O, Reiner A, Alestrom P, Collas P. The specific alteration of histone methylation profiles by DZNep during early zebrafish development. Biochim Biophys Acta. 2014;1839:1307-15 pubmed publisher..Altered H3K9me3 profiles were associated with severe neuronal and cranial phenotypes at day 4-5 post-fertilization. Thus, DZNep was shown to affect enrichment patterns of H3K27me3 and H3K9me3 at promoters in a gene-specific manner. ..
- Oldenburg A, Collas P. Mapping Nuclear Lamin-Genome Interactions by Chromatin Immunoprecipitation of Nuclear Lamins. Methods Mol Biol. 2016;1411:315-24 pubmed publisher..The protocol is compatible with polymerase chain reaction and high-throughput sequencing analysis of the co-immunoprecipitated DNA. ..