Ayman M Mahmoud
Mahmoud A, Al Dera H. 18Î²-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARÎ³ and Nrf2 upregulation. Genes Nutr. 2015;10:41 pubmed publisher
..This report also confers new information that 18Î²-GA protects liver against the toxic effect of chemotherapeutic alkylating agents via activation of Nrf2 and PPARÎ³. ..
Al Samhari M, Al Rasheed N, Al Rejaie S, Al Rasheed N, Hasan I, Mahmoud A, et al
. Possible involvement of the JAK/STAT signaling pathway in N-acetylcysteine-mediated antidepressant-like effects. Exp Biol Med (Maywood). 2016;241:509-18 pubmed publisher
..Therefore, depression research may target the JAK/STAT signaling pathway to provide a novel effective therapy. ..
Kamel E, Mahmoud A, Ahmed S, Lamsabhi A. A phytochemical and computational study on flavonoids isolated from Trifolium resupinatum L. and their novel hepatoprotective activity. Food Funct. 2016;7:2094-106 pubmed publisher
..Therefore, the present study provides the first clarification of the detailed antioxidant SARs of T. resupinatum flavonoids and points to the involvement of Nrf2 in their hepatoprotective activity. ..
Mahmoud A, Abd El Twab S, Abdel Reheim E. Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism. Eur J Nutr. 2017;56:1671-1684 pubmed publisher
..alba has protective effect on diabetic retinopathy with possible mechanisms of inhibiting hyperglycemia-induced oxidative stress, apoptosis, inflammation, polyol pathway activation, and VEGF expression in the retina. ..
Mahmoud A, Germoush M, Alotaibi M, Hussein O. Possible involvement of Nrf2 and PPAR? up-regulation in the protective effect of umbelliferone against cyclophosphamide-induced hepatotoxicity. Biomed Pharmacother. 2017;86:297-306 pubmed publisher
..In conclusion, the hepatoprotective effects of UMB appear to depend on co-activation of PPAR? and Nrf2, and subsequent suppression of oxidative stress and inflammation. ..
Mahmoud A, Zaki A, Hassan M, Mostafa Hedeab G. Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling. Chem Biol Interact. 2017;270:41-50 pubmed publisher
..In conclusion, these results provide evidence that C. molmol resin has a potent chemopreventive activity, possibly by up-regulating the Nrf2/HO-1 signaling and attenuation of inflammation, angiogenesis and oxidative stress. ..
Mahmoud A, Hussein O, Hozayen W, Abd El Twab S. Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPAR? and Nrf2: Protective effect of 18?-Glycyrrhetinic acid. Chem Biol Interact. 2017;270:59-72 pubmed publisher
..Therefore, 18?-GA can provide protection against MTX-induced hepatotoxicity. ..
Mahmoud A, Abd El Twab S. Caffeic acid phenethyl ester protects the brain against hexavalent chromium toxicity by enhancing endogenous antioxidants and modulating the JAK/STAT signaling pathway. Biomed Pharmacother. 2017;91:303-311 pubmed publisher
..In conclusion, CAPE protects the brain against Cr(VI) toxicity through abrogation of oxidative stress, inflammation and down-regulation of JAK2/STAT3 signaling in a SOCS3-independent mechanism. ..
Mahmoud A, Hozayen W, Ramadan S. Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPAR?, and suppressing oxidative stress and apoptosis in rats. Biomed Pharmacother. 2017;94:280-291 pubmed publisher
..In conclusion, BBR attenuated MTX-induced oxidative stress and apoptosis, possibly through up-regulating Nrf2/HO-1 pathway and PPAR?. Therefore, BBR can protect against MTX-induced liver injury. ..