Kanata E, Golanska E, Villar Piqué A, Karsanidou A, Dafou D, Xanthopoulos K, et al
. Cerebrospinal fluid neurofilament light in suspected sporadic Creutzfeldt-Jakob disease. J Clin Neurosci. 2018;: pubmed publisher
..77 to 0.96), respectively. CSF NFL was associated neither to age nor to sex but correlated with total-tau concentrations in both cohorts. Overall, our data provide independent validation of CSF NFL utility in sCJD differential diagnosis. ..
Schmitz M, Villar Piqué A, Llorens F, Gmitterova K, Hermann P, Varges D, et al
. Cerebrospinal Fluid Total and Phosphorylated ?-Synuclein in Patients with Creutzfeldt-Jakob Disease and Synucleinopathy. Mol Neurobiol. 2018;: pubmed publisher
..In conclusion, our data confirm t-?-synuclein and p-?-synuclein as robust biomarkers for sCJD and indicate the potential use of colorimetric t-?-synuclein ELISAs for differential diagnosis of dementia types. ..
Llorens F, Kruse N, Schmitz M, Shafiq M, da Cunha J, Gotzman N, et al
. Quantification of CSF biomarkers using an electrochemiluminescence-based detection system in the differential diagnosis of AD and sCJD. J Neurol. 2015;262:2305-11 pubmed publisher
..Importantly, Î±-synuclein levels detected by ECL allow an excellent discrimination between sCJD cases and AD and control cases, unveiling a new clinical approach for the differential diagnosis of sCJD. ..
Llorens F, Barrio T, Correia Â, Villar Piqué A, Thune K, Lange P, et al
. Cerebrospinal Fluid Prion Disease Biomarkers in Pre-clinical and Clinical Naturally Occurring Scrapie. Mol Neurobiol. 2018;55:8586-8591 pubmed publisher
..Our work also supports the potential use of these tests in the screening of pre-symptomatic scrapie and human prion disease cases. ..
Villar Piqué A, Schmitz M, Lachmann I, Karch A, Calero O, Stehmann C, et al
. Cerebrospinal Fluid Total Prion Protein in the Spectrum of Prion Diseases. Mol Neurobiol. 2018;: pubmed publisher
..Our data indicate that CSF t-PrP concentrations may have a role as a pre-clinical or early symptomatic diagnostic biomarker in prion diseases as well as in the evaluation of therapeutic interventions. ..
Llorens F, Schmitz M, Gloeckner S, Kaerst L, Hermann P, Schmidt C, et al
. Increased albumin CSF/serum ratio in dementia with Lewy bodies. J Neurol Sci. 2015;358:398-403 pubmed publisher
..The present study demonstrates increased Qalb in synucleinopathies associated with dementia revealing a potential new clinical approach for the differential diagnosis of DLB. ..
Zerr I, Schmitz M, Karch A, Villar Piqué A, Kanata E, Golanska E, et al
. Cerebrospinal fluid neurofilament light levels in neurodegenerative dementia: Evaluation of diagnostic accuracy in the differential diagnosis of prion diseases. Alzheimers Dement. 2018;14:751-763 pubmed publisher
..Increased NFL levels are a common feature in neurodegenerative dementias. ..
Llorens F, Schmitz M, Karch A, Cramm M, Lange P, Gherib K, et al
. Comparative analysis of cerebrospinal fluid biomarkers in the differential diagnosis of neurodegenerative dementia. Alzheimers Dement. 2016;12:577-89 pubmed publisher
..Combining the biomarker panel allows differentiating between various types of neurodegenerative dementias and contributes to a better understanding of their pathophysiological processes. ..
LÃ³pez GonzÃ¡lez I, Garcia Esparcia P, Llorens F, Ferrer I. Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies. Int J Mol Sci. 2016;17:206 pubmed publisher