Merry L Lindsey

Summary

Publications

  1. Ma Y, Chiao Y, Clark R, Flynn E, Yabluchanskiy A, Ghasemi O, et al. Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence. Cardiovasc Res. 2015;106:421-31 pubmed publisher
    ..Our results explain early mechanisms that stimulate ageing-induced cardiac fibrosis and diastolic dysfunction. ..
  2. Ma Y, Yabluchanskiy A, Iyer R, Cannon P, Flynn E, Jung M, et al. Temporal neutrophil polarization following myocardial infarction. Cardiovasc Res. 2016;110:51-61 pubmed publisher
    ..This study is the first to identify the existence of N1 and N2 neutrophils in the infarct region and reveals that N1 polarization could be mediated by DAMPs. ..
  3. Toba H, Lindsey M. Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly. Pharmacol Ther. 2018;: pubmed publisher
    ..In particular, there is strong evidence that inflammatory cell-derived MMP-9 exacerbates cardiorenal aging. This review explores the potential therapeutic targets against CVD and CKD in the elderly, focusing on ECM and MMP roles. ..
  4. DeLeon Pennell K, Mouton A, Ero O, Ma Y, Padmanabhan Iyer R, Flynn E, et al. LXR/RXR signaling and neutrophil phenotype following myocardial infarction classify sex differences in remodeling. Basic Res Cardiol. 2018;113:40 pubmed publisher
    ..This is the first report to uncover sex differences in post-MI neutrophil signaling that yielded better outcomes in young females and worse outcomes with age. ..
  5. DeLeon Pennell K, de Castro Brás L, Iyer R, Bratton D, Jin Y, Ripplinger C, et al. P. gingivalis lipopolysaccharide intensifies inflammation post-myocardial infarction through matrix metalloproteinase-9. J Mol Cell Cardiol. 2014;76:218-26 pubmed publisher
    ..In conclusion, MMP-9 deletion has a cardioprotective role against PgLPS exposure, by attenuating macrophage mediated inflammation. ..
  6. Lindsey M. Assigning matrix metalloproteinase roles in ischaemic cardiac remodelling. Nat Rev Cardiol. 2018;: pubmed publisher
    ..MMP9 is used as an example MMP to explain these concepts and to provide a template for examining MMPs as mechanistic mediators of cardiac remodelling. ..
  7. Mouton A, DeLeon Pennell K, Rivera Gonzalez O, Flynn E, Freeman T, Saucerman J, et al. Mapping macrophage polarization over the myocardial infarction time continuum. Basic Res Cardiol. 2018;113:26 pubmed publisher
    ..In addition to serving as indirect mediators of ECM remodeling, macrophages are a direct source of ECM components. Our study is the first to report the detailed changes in the macrophage transcriptome over the first week of MI. ..
  8. Iyer R, Patterson N, Zouein F, Ma Y, Dive V, de Castro Brás L, et al. Early matrix metalloproteinase-12 inhibition worsens post-myocardial infarction cardiac dysfunction by delaying inflammation resolution. Int J Cardiol. 2015;185:198-208 pubmed publisher
    ..Our results reveal a novel protective mechanism for MMP-12 in neutrophil biology. Post-MI, MMP-12i impaired CD44-HA interactions to suppress neutrophil apoptosis and prolong inflammation, which worsened LV function. ..
  9. Yabluchanskiy A, Ma Y, DeLeon Pennell K, Altara R, Halade G, Voorhees A, et al. Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization. J Gerontol A Biol Sci Med Sci. 2016;71:475-83 pubmed publisher
    ..05), without affecting proinflammatory M1 markers. In conclusion, MMP-9 deletion stimulated anti-inflammatory polarization of macrophages to attenuate left ventricle dysfunction in the aging post-myocardial infarction. ..

More Information

Publications26

  1. Iyer R, Jung M, Lindsey M. MMP-9 signaling in the left ventricle following myocardial infarction. Am J Physiol Heart Circ Physiol. 2016;311:H190-8 pubmed publisher
    ..This overview will summarize how our understanding of MMP-9 has evolved over the last decade and will provide insight into future directions that will drive our understanding of MMP-9-directed cardiac ECM turnover in the post-MI LV. ..
  2. Iyer R, de Castro Brás L, Cannon P, Ma Y, DeLeon Pennell K, Jung M, et al. Defining the sham environment for post-myocardial infarction studies in mice. Am J Physiol Heart Circ Physiol. 2016;311:H822-36 pubmed publisher
    ..When a minimally invasive procedure to generate MI in mice was used, the D0 (no surgical operation) control was an adequate replacement for the use of sham surgery groups. ..
  3. DeLeon Pennell K, Lindsey M. Cardiac aging: Send in the vinculin reinforcements. Sci Transl Med. 2015;7:292fs26 pubmed publisher
    ..Integration of multiple analytical approaches across three species—fly, rat, and nonhuman primate—reveals additional roles for vinculin in cytoskeletal aging and cardiovascular disease (Kaushik et al., this issue). ..
  4. Iyer R, de Castro Brás L, Patterson N, Bhowmick M, Flynn E, Asher M, et al. Early matrix metalloproteinase-9 inhibition post-myocardial infarction worsens cardiac dysfunction by delaying inflammation resolution. J Mol Cell Cardiol. 2016;100:109-117 pubmed publisher
    ..In conclusion, early MMP-9 inhibition delayed inflammation resolution and exacerbated cardiac dysfunction, highlighting the importance of using translational approaches in mice. ..
  5. Lindsey M, Iyer R, Jung M, DeLeon Pennell K, Ma Y. Matrix metalloproteinases as input and output signals for post-myocardial infarction remodeling. J Mol Cell Cardiol. 2016;91:134-40 pubmed publisher
    ..A more complete understanding of MMP roles, particularly with regards to upstream signaling roles, may provide new strategies to limit adverse LV remodeling. ..
  6. Ramirez T, Iyer R, Ghasemi O, Lopez E, Levin D, Zhang J, et al. Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects. J Mol Cell Cardiol. 2014;72:326-35 pubmed publisher
    ..This study shows that MMP-9 regulates aliskiren and valsartan effects in mice. These results in mice provide mechanistic insight to help translate these findings to post-MI patients. ..
  7. Nielsen S, Mouton A, DeLeon Pennell K, Genovese F, Karsdal M, Lindsey M. Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes. Matrix Biol. 2017;: pubmed publisher
    ..This review focuses on post-MI LV ECM remodeling, targeting the discussion on ECM biomarkers that could be useful for predicting MI outcomes. ..
  8. Ma Y, Mouton A, Lindsey M. Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction. Transl Res. 2018;191:15-28 pubmed publisher
    ..This review summarizes current knowledge about cardiac macrophage origins, roles, and phenotypes in the steady state, with aging, and after MI, as well as highlights outstanding areas of investigation. ..
  9. Meschiari C, Jung M, Iyer R, Yabluchanskiy A, Toba H, Garrett M, et al. Macrophage overexpression of matrix metalloproteinase-9 in aged mice improves diastolic physiology and cardiac wound healing following myocardial infarction. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00453.2017 pubmed publisher
    ..05 for both). In conclusion, macrophage-derived MMP-9 improved post-MI cardiac wound healing through direct and indirect mechanisms to improve diastolic physiology and remodeling...
  10. Lindsey M, de Castro Brás L. The physics of an academic career. Adv Physiol Educ. 2017;41:493-497 pubmed publisher
    ..Combined, these formulas provide tips for thriving in an academic environment. ..
  11. DeLeon Pennell K, Meschiari C, Jung M, Lindsey M. Matrix Metalloproteinases in Myocardial Infarction and Heart Failure. Prog Mol Biol Transl Sci. 2017;147:75-100 pubmed publisher
    ..This chapter focuses on the role of MMPs post-MI, the efficiency of MMPs as biomarkers for MI or heart failure, and the future of MMPs and their cleavage products as targets for prevention of post-MI heart failure. ..
  12. Pan H, Qin K, Guo Z, Ma Y, April C, Gao X, et al. Negative elongation factor controls energy homeostasis in cardiomyocytes. Cell Rep. 2014;7:79-85 pubmed publisher
    ..Our findings strongly indicate that NELF is part of the PPAR?-mediated transcription regulatory network that maintains metabolic homeostasis in cardiomyocytes. ..
  13. Jung M, Ma Y, Iyer R, DeLeon Pennell K, Yabluchanskiy A, Garrett M, et al. IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation. Basic Res Cardiol. 2017;112:33 pubmed publisher
    ..Combined, our results indicate that in vivo infusion of IL-10 post-MI improves the LV microenvironment to dampen inflammation and facilitate cardiac wound healing. ..
  14. Ma Y, Iyer R, Jung M, Czubryt M, Lindsey M. Cardiac Fibroblast Activation Post-Myocardial Infarction: Current Knowledge Gaps. Trends Pharmacol Sci. 2017;38:448-458 pubmed publisher
    ..This review summarizes current fibroblast knowledge as the foundation for a discussion of existing knowledge gaps. ..
  15. Meschiari C, Ero O, Pan H, Finkel T, Lindsey M. The impact of aging on cardiac extracellular matrix. GeroScience. 2017;39:7-18 pubmed publisher
    ..Understanding the complexity of the molecular interactions between MMPs and the ECM in the context of aging may provide novel diagnostic indicators for the early detection of age-related fibrosis and cardiac dysfunction. ..
  16. Toba H, Cannon P, Yabluchanskiy A, Iyer R, D ARMIENTO J, Lindsey M. Transgenic overexpression of macrophage matrix metalloproteinase-9 exacerbates age-related cardiac hypertrophy, vessel rarefaction, inflammation, and fibrosis. Am J Physiol Heart Circ Physiol. 2017;312:H375-H383 pubmed publisher
    ..We found that an elevation in macrophage-derived MMP-9 induced a greater age-dependent cardiac hypertrophy and vessel rarefaction phenotype, which enhanced cardiac inflammation and fibrosis. ..
  17. Lindsey M, Saucerman J, DeLeon Pennell K. Knowledge gaps to understanding cardiac macrophage polarization following myocardial infarction. Biochim Biophys Acta. 2016;1862:2288-2292 pubmed publisher
    ..This article is part of a Special Issue entitled: The role of post-translational protein modifications on heart and vascular metabolism edited by Jason R.B. Dyck & Jan F.C. Glatz. ..