Merry L Lindsey
Ma Y, Chiao Y, Clark R, Flynn E, Yabluchanskiy A, Ghasemi O, et al
. Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence. Cardiovasc Res. 2015;106:421-31 pubmed publisher
..Our results explain early mechanisms that stimulate ageing-induced cardiac fibrosis and diastolic dysfunction. ..
Ma Y, Yabluchanskiy A, Iyer R, Cannon P, Flynn E, Jung M, et al
. Temporal neutrophil polarization following myocardial infarction. Cardiovasc Res. 2016;110:51-61 pubmed publisher
..This study is the first to identify the existence of N1 and N2 neutrophils in the infarct region and reveals that N1 polarization could be mediated by DAMPs. ..
Toba H, Lindsey M. Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly. Pharmacol Ther. 2018;: pubmed publisher
..In particular, there is strong evidence that inflammatory cell-derived MMP-9 exacerbates cardiorenal aging. This review explores the potential therapeutic targets against CVD and CKD in the elderly, focusing on ECM and MMP roles. ..
DeLeon Pennell K, Mouton A, Ero O, Ma Y, Padmanabhan Iyer R, Flynn E, et al
. LXR/RXR signaling and neutrophil phenotype following myocardial infarction classify sex differences in remodeling. Basic Res Cardiol. 2018;113:40 pubmed publisher
..This is the first report to uncover sex differences in post-MI neutrophil signaling that yielded better outcomes in young females and worse outcomes with age. ..
DeLeon Pennell K, de Castro BrÃ¡s L, Iyer R, Bratton D, Jin Y, Ripplinger C, et al
. P. gingivalis lipopolysaccharide intensifies inflammation post-myocardial infarction through matrix metalloproteinase-9. J Mol Cell Cardiol. 2014;76:218-26 pubmed publisher
..In conclusion, MMP-9 deletion has a cardioprotective role against PgLPS exposure, by attenuating macrophage mediated inflammation. ..
Lindsey M. Assigning matrix metalloproteinase roles in ischaemic cardiac remodelling. Nat Rev Cardiol. 2018;: pubmed publisher
..MMP9 is used as an example MMP to explain these concepts and to provide a template for examining MMPs as mechanistic mediators of cardiac remodelling. ..
Mouton A, DeLeon Pennell K, Rivera Gonzalez O, Flynn E, Freeman T, Saucerman J, et al
. Mapping macrophage polarization over the myocardial infarction time continuum. Basic Res Cardiol. 2018;113:26 pubmed publisher
..In addition to serving as indirect mediators of ECM remodeling, macrophages are a direct source of ECM components. Our study is the first to report the detailed changes in the macrophage transcriptome over the first week of MI. ..
Iyer R, Patterson N, Zouein F, Ma Y, Dive V, de Castro BrÃ¡s L, et al
. Early matrix metalloproteinase-12 inhibition worsens post-myocardial infarction cardiac dysfunction by delaying inflammation resolution. Int J Cardiol. 2015;185:198-208 pubmed publisher
..Our results reveal a novel protective mechanism for MMP-12 in neutrophil biology. Post-MI, MMP-12i impaired CD44-HA interactions to suppress neutrophil apoptosis and prolong inflammation, which worsened LV function. ..
Yabluchanskiy A, Ma Y, DeLeon Pennell K, Altara R, Halade G, Voorhees A, et al
. Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization. J Gerontol A Biol Sci Med Sci. 2016;71:475-83 pubmed publisher
..05), without affecting proinflammatory M1 markers. In conclusion, MMP-9 deletion stimulated anti-inflammatory polarization of macrophages to attenuate left ventricle dysfunction in the aging post-myocardial infarction. ..