Hae Young Chung


Affiliation: Pusan National University
Country: Korea


  1. Jeong J, Lee B, Kim D, Jeong H, Moon K, Kim M, et al. Mechanism of Action of Magnesium Lithospermate B against Aging and Obesity-Induced ER Stress, Insulin Resistance, and Inflammsome Formation in the Liver. Molecules. 2018;23: pubmed publisher
    ..These results suggest that MLB may improve insulin resistance in the liver at least partially by suppressing ER stress and inflammasome formation in aging and obese animal models. ..
  2. Kim M, Park C, Kim D, Park M, Park K, Hyun M, et al. Hepatoprotective Effects of MHY3200 on High-Fat, Diet-Induced, Non-Alcoholic Fatty Liver Disease in Rats. Molecules. 2018;23: pubmed publisher
    ..Our results suggested that MHY3200 ameliorated HFD-induced hepatic lipid accumulation and inflammation, and improved insulin resistance through PPAR? activation. ..
  3. Jung H, Lee A, Park Y, Lee S, Kang D, Jung Y, et al. (2E,5E)-2,5-Bis(3-hydroxy-4-methoxybenzylidene) cyclopentanone Exerts Anti-Melanogenesis and Anti-Wrinkle Activities in B16F10 Melanoma and Hs27 Fibroblast Cells. Molecules. 2018;23: pubmed publisher
    ..Therefore, our results demonstrate that BHCP may be a good candidate for the development of therapeutic agents for diseases associated with hyperpigmentation and wrinkling. ..
  4. Chung K, Choi Y, Park M, Jang E, Kim D, Park B, et al. Molecular Insights into SIRT1 Protection Against UVB-Induced Skin Fibroblast Senescence by Suppression of Oxidative Stress and p53 Acetylation. J Gerontol A Biol Sci Med Sci. 2015;70:959-68 pubmed publisher
    ..The study identifies a new role for SIRT1 in the UVB-induced senescence of skin fibroblats and provides a potential target for skin protection through molecuar insights into the mechanisms responsible for UVB-induced photoaging. ..
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    Chung H, Sung B, Jung K, Zou Y, Yu B. The molecular inflammatory process in aging. Antioxid Redox Signal. 2006;8:572-81 pubmed
  6. Park M, Kim D, Kim M, Lee E, An H, Jeong J, et al. Effects of MHY908, a New Synthetic PPARα/γ Dual Agonist, on Inflammatory Responses and Insulin Resistance in Aged Rats. J Gerontol A Biol Sci Med Sci. 2016;71:300-9 pubmed publisher
  7. Chung H, Lee E, Choi Y, Kim J, Kim D, Zou Y, et al. Molecular inflammation as an underlying mechanism of the aging process and age-related diseases. J Dent Res. 2011;90:830-40 pubmed publisher
    ..The final section discusses calorie restriction as an aging-retarding intervention that also exhibits extraordinarily effective anti-inflammatory activity by modulating GSH redox, NF-?B, SIRT1, PPARs, and FOXOs. ..
  8. Eom S, Liu S, Su M, Noh T, Hong J, Kim N, et al. Synthesis of Phthalimide Derivatives as Potential PPAR-? Ligands. Mar Drugs. 2016;14: pubmed publisher
    ..However, in in vitro assays, PD1 and PD2 consistently displayed significant PPAR-? activation in Ac2F and HepG2 cells, and adipogenic activity in 3T3-L1 preadipocytes. ..
  9. Kim D, Kim S, Lee B, Lee E, Chung K, Moon K, et al. Effect of betaine on hepatic insulin resistance through FOXO1-induced NLRP3 inflammasome. J Nutr Biochem. 2017;45:104-114 pubmed publisher
    ..Our results suggest that betaine inhibits the FOXO1 binding to TXNIP, leading to the suppression of RS-induced NLRP3 inflammasome activation in a diabetic liver. ..

More Information


  1. Jeong H, Park D, Im E, Lee J, Im D, Chung H. Determination of the Mechanisms that Cause Sarcopenia through cDNA Microarray. J Frailty Aging. 2017;6:97-102 pubmed publisher
    ..These results suggest that mitochondrial dysfunction and lipid metabolism are associated with sarcopenia. ..
  2. Chung K, Lee E, Lee M, Oh G, Yu B, Chung H. Impairment of PPARα and the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging. J Am Soc Nephrol. 2018;29:1223-1237 pubmed publisher
    ..Our results suggest that impaired renal PPARα signaling during aging aggravates renal fibrosis development, and targeting PPARα is useful for preventing age-associated CKD. ..
  3. Chung H, Cesari M, Anton S, Marzetti E, Giovannini S, Seo A, et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev. 2009;8:18-30 pubmed publisher
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    Chung H, Kim H, Kim K, Choi J, Yu B. Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction. Microsc Res Tech. 2002;59:264-72 pubmed
    ..It was further proposed that CR's major force of the regulation of redox-sensitive inflammation may well be its life-prolonging action. ..
  5. Jeong J, Kim J, Ku S, Kim S, Kim K, Kim G, et al. Essential oils purified from Schisandrae semen inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 activation and migration of human aortic smooth muscle cells. BMC Complement Altern Med. 2015;15:7 pubmed publisher
    ..Taken together, these results suggest that SSeo has putative potential anti-atherosclerotic activity. ..
  6. Kim C, Lee E, Choi Y, An H, Jeong H, Park D, et al. Short-term calorie restriction ameliorates genomewide, age-related alterations in DNA methylation. Aging Cell. 2016;: pubmed publisher
    ..Therefore, the CR-induced epigenetic changes that ameliorate age-dependent aberrant methylation may be important to CR's health- and life-prolonging effects. ..
  7. Kim M, An H, Kim D, Lee B, Lee H, Ullah S, et al. Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice. Bioorg Med Chem Lett. 2018;28:684-688 pubmed publisher
    ..In conclusion, the novel SIRT1 activator MHY2233 reduced lipid accumulation and improved insulin resistance. This finding may contribute toward therapeutic approaches for fatty liver disease and glucose tolerance. ..
  8. Kim Y, Lee E, Kim D, Kim K, Lee B, An H, et al. PPAR? activation by MHY908 attenuates age-related renal inflammation through modulation of the ROS/Akt/FoxO1 pathway. Exp Gerontol. 2017;92:87-95 pubmed publisher
    ..These phenomena suggest that PPAR? activation by MHY908 attenuates NOX4-derived ROS generation in response to insulin. ..
  9. Na H, Pyo J, Jeon H, Park J, Chung H, Yoo M. Deficiency of Atg6 impairs beneficial effect of metformin on intestinal stem cell aging in Drosophila. Biochem Biophys Res Commun. 2018;498:18-24 pubmed publisher
    ..Taken together, our study suggests that Atg6 is required for the inhibitory effect of metformin on ISC aging, providing an intervention mechanism of metformin on adult stem cell aging. ..